Abdelmonem Hegazy's profile, Faculty of Dentistry, Zarqa University, Jordan

Abdelmonem Hegazy

Jordan Faculty of Dentistry, Zarqa University, Jordan

111 Papers

0 Following

0 Followers

Profile

Research field: Anatomy;, Embryology;, Histopathology, Gynecology, Obstetrics

Bio: Professor of Human Anatomy and Embryology Department in Faculty of Dentistry, Zarqa University, Jordan & Faculty of Medicine, Zagazig University & Faculty of Dentistry, Zarqa University, Jordan. He is... More

Position: Professor

Personal page: http://www.aamosttafa.faculty.zu.edu.eg/

LinkedIn: https://www.linkedin.com/in/abdelmonem-hegazy-8369b745/

ORCID: 0000-0002-5993-6618

Address: Faculty of Dentistry, Zarqa University, Jordan & Faculty of Medicine, Zagazig University, Egypt

Recent visitor(s)

It has been quiet lately.

Published in 2014

Fine needle aspiration cytology and cell-block study of various breast lumps-: Breast Histology Pathology FNAC; Authors: RA Hegazy, AA Hegazy, FA Fetouh, S Ibrahim; Journal: American Journal of Biomedical and Life Sciences. Vol. 2, No. 1, 2014, pp. 8-17.".

Description:: Aim of the study was to evaluate the importance of the combined use of fine needle aspiration cytology (FNAC) and cell-block in the diagnosis of different breast lesions. Patient and methods: This study was a prospective study of 310 cases (301 females and 9 males) with breast swelling, coming to cytopathology unit, faculty of medicine, Zagazig University. FNAC and cell-block were performed. Cytological findings of smears and cell-blocks were correlated to histopathological results. Results: Most of cases were diagnosed as benign lesions or normal findings. The majority of FNAC samples was diagnosed as fibrocystic disease (160 cases, 51.6%), followed by fibroadenoma in 54 cases (17.4%). Positive cases for malignancy, including non-Hodgkin lymphoma and false negative cases were encountered in 50 cases (16.1%). Studying the histopathological results showed that true positive cases by FNAC and cell-block were 47 in number (15.16%) and true negative ones were 247 cases (82.90%). False positive cases were 3 in number (0.96%) and false negative ones were also 3 cases (0.96%). Sensitivity was 94% and specificity was 98%. Positive predictive and negative predictive values were 94% and 98%, respectively. False positive and false negative rates were 1.15% and 6% respectively. Total accuracy was 98%. Conclusion: It is advised to perform cell-blocks for each case of breast FNAC to decrease the pitfalls and to improve the diagnosis and management of breast lumps.

Published in 2014

Immunohistochemical Expression of Aldehyde Dehydrogenase-1 and Hypoxia- Inducible Factor-1 alpha in Breast Cancer.: Immunohistochemistry Breast cancer Cancer stem cells; Authors: T Ibrahim, S Abdel Raouf, A Hegazy; Journal: Int. J. of Adv. Res. 2 (7): 822-830, 2014

Description:: Aim of the work: to evaluate the expression of ALDH-1 and HIF-1α in primary breast cancer and their relation to clinicopathological parameters using immunohistochemical methods. Material and Methods: Fifty paraffin blocks of primary breast cancer immunostained by ALDH-1 and HIF-1α immunohistochemical markers. Results: Increasing expression of HIF-1α was positively associated with nodal metastasis and histological grade, P value =0.001 and 0.036 respectively. There was a significant negative association between ALDH-1 expression and ER and PR expression, P value = 0.002 and 0.004 respectively. Also, there was a significant negative association between HIF-1α expression and ER and PR expression, P value =0.029 and 0.018 respectively. Conclusions: An association was found between ALDH-1 expression and HIF-1α expression in breast carcinomas. Their negative association to hormonal (estrogen and progesterone) receptors suggests that they might play an important role in drug resistance, and may be used as prognostic markers.

Published in 2014

Expression and Significance of Ezrin and E-cadherin in Colorectal Carcinoma: Authors: S Abd-El Raouf, T Ibrahim, A Hegazy; Journal: Int. J. of Adv. Res. 2 (7): 936-944, 2014.

Description:: Background: Colorectal carcinoma (CRC) is the third most common human cancer and the fourth most common cause of cancer deaths. Ezrin may be involved in several functions including cell adhesion, motility and cell survival. There is increasing evidence that it regulates tumor progression and metastasis. Also E-cadherin dysfunction is proposed to contribute to cancer progression, facilitating proliferation, invasion, and possibly metastasis. Aim: To evaluate the expression of Ezrin and E-cadherin in colorectal carcinoma and its relation to clinicopathological parameters. Material and Methods: The expressions of Ezrin and E-cadherin were detected by immunohistochemical staining (streptavidine-peroxidase method) in 50 cases of colorectal carcinoma and their adjacent normal colorectal mucosa. Results: The expression of Ezrin in colorectal carcinoma was significantly higher than that in normal colorectal mucosa (74% versus 20%, P < 0.001).The expression of E-cadherin in colorectal carcinoma was significantly lower than that in adjacent normal colorectal mucosa (32% versus 100%, P < 0.001). Ezrin and E-cadherin expression were associated with decreased tumor differentiation, advanced Dukes stage and lymph node metastasis (P<0.05). Ezrin expression was associated with invasion depth (P=0.009).The expressions of E-cadherin and Ezrin were negative related in colorectal cancer (P<0.001). Conclusion: Ezrin and E-cadherin are associated with the tumorigenesis and development of colorectal cancer, and play an important role in invasion and metastasis processes. Combined detection of the expression of E-cadherin and Ezrin may serve as an important prognostic predictor for colorectal cancer.

Published in 2014

Midsagittal Anatomy of Lumbar Lordosis in Adult Egyptians: MRI Study: Anatomy Lumbar Lordosis MRI; Authors: AA Hegazy, RA Hegazy; Journal: Anatomy Research International, Volume 2014 (2014), Article ID 370852, 12 pages

Description:: Despite the increasing recognition of the functional and clinical importance of lumbar lordosis, little is known about its description, particularly in Egypt. At the same time, magnetic resonance imaging (MRI) has been introduced as a noninvasive diagnostic technique. The aim of this study was to investigate the anatomy of the lumbar lordosis using midsagittal MRIs. Normal lumbar spine MRIs obtained from 93 individuals (46 males, 47 females; 25–57 years old) were evaluated retrospectively. The lumbar spine curvature and its segments “vertebrae and discs” were described and measured. The lumbar lordosis angle (LLA) was larger in females than in males. Its mean values increased by age. The lumbar height (LH) was longer in males than in females. At the same time, the lumbar breadth (LB) was higher in females than in males. Lumbar index (LI = LB/LH × 100) showed significant gender differences (). Lordosis was formed by wedging of intervertebral discs and bodies of lower lumbar vertebrae. In conclusion, MRI might clearly reveal the anatomy of the lumbar lordosis. Use of LI in association with LLA could be useful in evaluation of lumbar lordosis.

Published in 2014

ANTHROPOMETRIC STUDY OF NASAL INDEX OF EGYPTIANS: Anthropometry anatomy nasal index sexual dimorphism; Authors: AA Hegazy; Journal: International Journal of Anatomy and Research, 2014 (Volume 2 Issue 4), 761-67;

Description:: Background: The nasal index determination is one of the most commonly used anthropometric parameters in classifying human races. There are few reports in medical literature concerning nasal index that specifically address particular Egyptian populations. The objective of this study was to determine the normal parameters of external nose (width, height and nasal index) in Egyptians. Methods: The study was conducted randomly on healthy Egyptian subjects of both sexes. Nasal height and width were measured using vernier caliper. Then, nasal index was determined for each subject. The obtained data were subjected to statistical analysis. Results: A total of 290 subjects, 144males and 146 females, aged 1month– 65 years, were enrolled in the study. The study showed the existence of sexual dimorphism in nasal morphology, appearing after the age 20 years. The mean nasal index in the investigated adults was 68.01; in males and females was 71.46 and 64.56, respectively. Conclusions: The dominant nasal type in Egyptians was in-between mesorrhine “medium” and leptorrhine “narrow” nose. Forensic and anthropological research, as well as cosmetic and reconstructive surgery may benefit from age- and sex- based data of the study.

Published in 2014

EFFECT OF CYCLOSPORINE A ON THE KIDNEY OF RABBIT: A LIGHT AND ULTRASTRUCTURAL STUDY: Kidney Cyclosporine A Nephrotoxicity Ultrastructure; Authors: FA Fetouh, AA Hegazy; Journal: International Journal of Anatomy and Research, 2014 (Volume 2 Issue 4), 768-76

Description:: Background: Nephrotoxicity is a relatively common problem in patients immunosuppressed with cyclosporine A (CsA) with an incidence reaching up to thirty percent. The present work aimed to study the histological and ultrastructural effects of CsA on the kidney of rabbit. Materials and Methods: Two groups of Egyptian adult rabbits were used for this study (5 rabbits for each). One group was used as a control and the other group (experimental) was treated with CsA in a dose of 15 mg/kg of body weight for two weeks. The animals were anaesthetized; and kidney specimens were obtained, fixed and processed for light and electron microscopic examinations. Results: CsA had adverse effects on the kidney especially renal corpuscles, proximal convoluted tubules, distal convoluted tubules and afferent glomerular arterioles. The renal corpuscles were observed with shrunken glomeruli, widening of Bowmanʼs space and thickening of the Bowmanʼs capsule. Also, there was obvious increase in mesangial cell number and overall glomerular obliteration due to large lining endothelial cells and encroachment of the mesangial cell matrix onto the capillary lumen. The renal tubules showed vacuolization and PAS positive inclusion bodies. The cells showed disordered brush border of microvilli. Many fibrocytes appeared inbetween the tubules. Peritubular capillary congestion was observed with an increase in the surrounding connective tissue. Ultrastructurally, the proximal convoluted tubules showed thick basement membrane with loss of the basal infolding. The mitochondria appeared degenerated with damaged transverse cristae. Electron dense lysosomes were seen in the cytoplasm. In distal convoluted tubules, the cells showed degenerated mitochondria and pyknotic nuclei. The afferent glomerular arterioles appeared with hyperplasia of juxtaglomerular cells that contained massive renin granules. The lining endothelial cells appeared protruding their nuclei into the lumen due to contraction of the smooth muscles. Conclusions: It could be concluded that CsA had adverse structural changes on the kidney mainly on the nephron; renal corpuscles, proximal convoluted tubules, distal convoluted tubules and afferent glomerular arterioles. Defective renal function should always be a concern in the management of CsA treated patient.

Published in 2014

CLINICOPATHOLOGICAL SIGNIFICANCE AND CORRELATION OF SURVIVIN, HER2 AND BCL2 EXPRESSION IN BREAST CARCINOMA: Immunohistochemical Breast Carcinoma Anatomy; Authors: AM Abdelbary, WS Elsayed, AA Hegazy; Journal: Zagazig University Medical Journal; Vol. 20; N.6 November; 2014: 883-898.

Description:: Background: Breast cancer is the most common cancer among females worldwide, accounting more than one third of the total percentage of all cancers in Egypt. Objective: This study aimed to correlate the immunohistochemical expression of survivin, HER2 and BCL2 with the clinicopathological variables in breast carcinoma to clarify the effect of marker expression on tumor behavior and prognosis. Methods: Immunohistochemical expressions of the three biomarkers were evaluated in 65 cases of breast carcinoma and the harvested data were correlated with clinicopathological parameters. Results: The specimens were 55 infiltrating duct carcinoma (IDC) and 10 cases of ductal carcinoma in situ (DCIS). Survivin was expressed in 3 cases (30%) of DCIS and in 40 cases (72.7%) of IDC. There was a positive significant association between survivin expression and tumor size. Also, there was a significant association between survivin expression and histological grade, tumor stage and LN metastases. Significant relationship between survivin expression and both estrogen receptor negative and progesterone receptor negative hormonal status was noticed. HER2 was expressed in 5 cases (50%) of DCIS and in 20 cases (36.4%) of IDC. There was a positive significant association between HER2expression and tumor size, tumor stage and LN metastases. The expression of HER-2 had a significant negative correlation with a status of estrogen (ER) and progesterone receptors (PR). BCL2 was expressed in 7 cases 70% of DCIS and in 42 cases (76.3%) of IDC. There was increased BCL2 expression in small sized-tumors. Also there is a highly significant association between BCL2expression and grade of tumors. There was no significant association betweenBCl2 expression and stage of tumors and LN metastases. The expression of BCL2 had a significant positive correlation with a status of ER & PR. Conclusion: Both survivin and HER2 are prognostic biomarkers, but BCL2 expression is associated with low grade tumor, small size and positive ER and PR.

Published in 2013

Age-Related Changes in Rabbit Optic Nerve: A Morphological Study: Anatomy Senility Optic nerve Morphology; Authors: FA Fetouh, AA Hegazy; Journal: Journal of American Science 2013;9(10);86-77

Description:: Aging is associated with neurological symptoms and signs that are suggestive of peripheral neuropathy. The impact of aging on the optic nerve is of general interest. Objective: The present work aimed to study the effect of aging on the morphological changes in the optic nerve of rabbit. Material and methods: Four groups of Egyptian (Gabali) rabbits (5 rabbits per group) at different postnatal ages; one month old (young), 6 months old (early adult), 18 months old (late adult) and 30 months old (senile) were used in this study. The animals were anaesthetized and rapidly dissected. Optic nerve specimens were obtained and processed for light and electron microscopic (EM) examinations. Results: In young animals, the optic nerve fibres appeared as closely packed myelinated axons of small diameters which were separated by processes of astrocytes. In early adult animals, the optic nerve fibres had the same structure to that of the young ones except that the axons were of larger diameters. The astrocytes and oligodendrocytes were observed with no differences in the structure in both young and early adult animals. In late adult animals, the optic nerve fibres were still closely packed but arranged into fascicles by thick processes. There were some depleted areas filled by degenerating axons and neuroglial cells. The degenerating axons showed electron dense axoplasm and redundant sheaths were frequent. The neuroglial cells occupied the depleted areas, were astrocytes and oligodendrocytes. In senile animals, there was an obvious loss of the optic nerve fibres. Extensive degeneration of the nerve axons and their myelin sheath were observed. The astrocytes appeared with pyknotic nucleus and abundant cytoplasmic filaments. The oligodendrocytes had irregular nucleus and the cytoplasm contained vacuoles and inclusion bodies. Conclusion: With progress of age, starting from the late adulthood, the optic nerve fibres show degenerative changes in the optic nerve axons, myelin sheath and the neuroglial cells which were to be extensive in senile age.

Published in 2013

Sex Assessment of the First Sacral Vertebra, MRI Study-: MRI Sex assessment Anatomy Sacrum; Authors: AA Hegazy; Journal: Journal of American Science 2013;9(10)

Description:: Determination of sex from the skeletal remains is of vital medico-legal importance for establishing the identity of an individual. Aims: To study the sexual differences in the first sacral vertebra (S1) in middle-aged adults through devising new parameters and indices. Material and Methods: 100 mid-sagittal MR images of lumbosacral region (50 males and 50 females) were investigated. The dimensions of S1 as well as inclination angles of sacrum were measured and statistically analyzed. Results: Male S1 showed higher values than that of female S1 in all of the investigated parameters, except for LSA. The parameters showed sex differences of variable levels. Also, Index 1(ID/SD×100) and Index 2 (PH/AH×100) showed significant sex differences. Application of univariate ANOVA revealed an accuracy in assigning sex of S1 for 95% of the cases, with accurate predictions being made for 97.5% of females and 92.5% of males. Conclusion: The body of the first sacral vertebra (S1) is a good bone for sex determination. The newly devised MRI parameters of S1 might be used to aid in identification of human skeletal and fleshed remains.

Published in 2013

Expression of β-Catenin and Cyclooxygenase 2 in Colorectal Carcinoma: An Immunohistochemical Study-: Colorectal Cancer Pathology Histology Immunohistochemical Staining; Authors: RA Hegazy, AA Hegazy, HR Abdel-Aziz, AF Mohamed, AM Mohamed; Journal: Universal Journal of Medical Science 2013, 1(3):72-77

Description:: The Wnt/β-catenin pathway plays an important role in the genesis of familial adenomatous polyposis, the most common form of inherited colorectal carcinoma (CRC). Also, the inflammatory bowel diseases (IBDs) predispose to cancer development; and cyclooxygenase 2 (COX-2) seems to be pivotal in their pathogenesis. This study aimed to investigate the relationship between the expression of COX-2 protein and β-catenin in colorectal cancer. The study enrolled 45 patients, all of whom underwent surgery and immunohistochemical staining of tissue specimens for COX-2 and β-catenin was done. Correlation between the two modulators and their relationship with clinicopathological features were examined. In 34 cases (75.56%) of the tumor samples; β-catenin immunoreactivity was found in the cytoplasm and/or membrane compartment. On the other hand, COX-2 immunoreactivity was weakly and/or strongly positive in 32 cases (71.11%) and negative in 13 (28.89%). Positivity was detected in the cytoplasm and in the perinuclear area. Increased expression of β-catenin was correlated to Duke stage (P=0.009). Furthermore, nuclear β-catenin localization showed a correlation to the Duke stage (P=0.029) and insignificant correlation with distant metastases (P = 0.336). Positive COX-2 expression showed a significant relation to, liver metastases (P = 0.042), and Duke stage (P = 0.011) and insignificant correlation to lymph node invasion (P=0.25). These data indicate that cytoplasmic/membrane β-catenin over-expressions as well as positive COX-2 expressions are associated with a more aggressive behavior of the disease.