Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

Neuron–astrocyte signaling and epilepsy

(2011) Gerald Seifert et al.   EXPERIMENTAL NEUROLOGY

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10)

(2011) Nadia Nabil Haj-Yasein et al.   GLIA

Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus

(2011) Susan Strohschein et al.   GLIA

Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality

(2011) Laura M. Magnotti et al.   GLIA

Autism with Seizures and Intellectual Disability: Possible Causative Role of Gain-of-function of the Inwardly-Rectifying K+ Channel Kir4.1

(2011) Federico Sicca et al.   NEUROBIOLOGY OF DISEASE

Role of Astrocytes in Neurovascular Coupling

(2011) Gabor C. Petzold et al.   NEURON

Targeting Pannexin1 Improves Seizure Outcome

(2011) Marcelo F. Santiago et al.   PLoS One

Astroglial networks scale synaptic activity and plasticity

(2011) U. Pannasch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

(2011) V. Benfenati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Variable loss of Kir4.1 channel function in SeSAME syndrome mutations

(2010) Xiaofang Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spinal cord injury causes a wide-spread, persistent loss of Kir4.1 and glutamate transporter 1: benefit of 17 -oestradiol treatment

(2010) M. L. Olsen et al.   BRAIN

Astrocyte heterogeneity: an underappreciated topic in neurobiology

(2010) Ye Zhang et al.   CURRENT OPINION IN NEUROBIOLOGY

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice

(2010) Mikhail Inyushin et al.   EPILEPSIA

Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion

(2010) Jinny J. Yoon et al.   EPILEPSY RESEARCH

Functional heterotypic interactions between astrocyte and oligodendrocyte connexins

(2010) Laura M. Magnotti et al.   GLIA

Role of astroglial connexin30 in hippocampal gap junction coupling

(2010) Dominic Gosejacob et al.   GLIA

Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32

(2010) Marta Maglione et al.   GLIA

Molecular Mechanisms of EAST/SeSAME Syndrome Mutations in Kir4.1 (KCNJ10)

(2010) Monica Sala-Rabanal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Dysfunction of Astrocytic Inwardly Rectifying K+ Channels Specific to the Neocortical Epileptic Focus After Fluid Percussion Injury in the Rat

(2010) Tessandra H. Stewart et al.   JOURNAL OF NEUROPHYSIOLOGY

Implication of Kir4.1 Channel in Excess Potassium Clearance: An In Vivo Study on Anesthetized Glial-Conditional Kir4.1 Knock-Out Mice

(2010) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Molecular Basis of Decreased Kir4.1 Function in SeSAME/EAST Syndrome

(2010) D. M. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Increased coupling and altered glutamate transport currents in astrocytes following kainic-acid-induced status epilepticus

(2010) D.K. Takahashi et al.   NEUROBIOLOGY OF DISEASE

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function

(2010) M. Reichold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

(2010) Marta Gómez-Gonzalo et al.   PLOS BIOLOGY

Heterogeneity in astrocyte morphology and physiology

(2009) Vitali Matyash et al.   BRAIN RESEARCH REVIEWS

Excitatory effects of gap junction blockers on cerebral cortex seizure-like activity in rats and mice

(2009) Logan J. Voss et al.   EPILEPSIA

Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy

(2009) Kjell Heuser et al.   EPILEPSY RESEARCH

Hippocampal seizures alter the expression of the pannexin and connexin transcriptome

(2009) Shanthini Mylvaganam et al.   JOURNAL OF NEUROCHEMISTRY

Connexin32 Mutations Cause Loss of Function in Schwann Cells and Oligodendrocytes Leading to PNS and CNS Myelination Defects

(2009) I. Sargiannidou et al.   JOURNAL OF NEUROSCIENCE

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit

(2009) G. Seifert et al.   JOURNAL OF NEUROSCIENCE

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

(2009) Lin Xu et al.   NEUROBIOLOGY OF DISEASE

Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, andKCNJ10Mutations

(2009) Detlef Bockenhauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus

(2009) A. Kunze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10

(2009) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of cytokines in the pathophysiology of epilepsy

(2008) Annamaria Vezzani et al.   BRAIN BEHAVIOR AND IMMUNITY

Connexin 43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures

(2008) Marina Samoilova et al.   EXPERIMENTAL NEUROLOGY

Functional implications for Kir4.1 channels in glial biology: from K+buffering to cell differentiation

(2008) Michelle L. Olsen et al.   JOURNAL OF NEUROCHEMISTRY

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

Connexins, pannexins, innexins: novel roles of “hemi-channels”

(2008) Eliana Scemes et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

ATP signalling in epilepsy

(2008) Ashwin Kumaria et al.   Purinergic Signalling

Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission

(2008) N. Rouach et al.   SCIENCE

Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

(2008) R. J. Thompson et al.   SCIENCE

Antiepileptic effect of carbenoxolone on seizures induced by 4-aminopyridine: A study in the rat hippocampus and entorhinal cortex

(2007) Laura Medina-Ceja et al.   BRAIN RESEARCH

Brain metabolism and diffusion in the rat cerebral cortex during pilocarpine-induced status epilepticus

(2007) Karel Slais et al.   EXPERIMENTAL NEUROLOGY

Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells

(2007) Hua Zhang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE