期刊
GLIA
卷 59, 期 1, 页码 26-34出版社
WILEY
DOI: 10.1002/glia.21073
关键词
gap junction; connexin; myelin; glia
资金
- NIH [RO1 GM37751, RO1 GM18974, P30-HD18655]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD018655] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R01EY002430] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM018974, R01GM037751] Funding Source: NIH RePORTER
Human genetic diseases and mouse knockouts illustrate that the maintenance of central nervous system myelin requires connexin expression by both astrocytes and oligo-dendrocytes. Because these cell types express nonoverlapping sets of connexins, the intercellular channels formed between them must be asymmetric with regard to connexin content, defined as heterotypic. Here, we show that oligodendrocyte Cx47 can form heterotypic channels with astrocyte Cx43 or Cx30 but not Cx26, whereas oligodendrocyte Cx32 can functionally interact with astrocyte Cx30 or Cx26 but not Cx43. Thus, as many as four types of intercellular channels could be formed between astrocytes and oligodendrocytes. (C) 2010 Wiley-Liss, Inc.
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