Article
Biochemistry & Molecular Biology
Gonzalo Ferreira, Axel Santander, Romina Cardozo, Luisina Chavarria, Lucia Dominguez, Nicolas Mujica, Milagros Benitez, Santiago Sastre, Luis Sobrevia, Garth L. Nicolson
Summary: Inwardly rectifying potassium (Kir) channels are important for maintaining membrane potential and potassium homeostasis. These channels have various subtypes and can be regulated by molecules found in nutrients, such as phosphoinositols, polyamines, and Mg2+. Changes in Kir channels can affect metabolism and the ability to absorb nutrients and electrolytes. The study of nutrigenomics of ion channels is crucial for understanding how diet and nutrients can impact ion channel function, expression, and lead to pathological conditions that affect diet and electrolyte intake.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Mariko Kato Hayashi, Kaoru Sato, Yuko Sekino
Summary: Neurons induce astrocyte branches and make them avoid each other, potentially contributing to the tiling of astrocytes' territories.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Leonid P. Savtchenko, Kaiyu Zheng, Dmitri A. Rusakov
Summary: Research has shown that high-affinity glutamate transporters can efficiently constrain extrasynaptic spread of glutamate, even when diffusion passages are relatively open, highlighting the importance of perisynaptic environment in preventing glutamate escape.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Hong-Ju Yang, Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Glutamate negatively regulates the rewarding effects of cocaine in the nucleus accumbens, but excess glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Kyle J. Brymer, Jocelyn R. Barnes, Matthew P. Parsons
Summary: Glutamate transporter proteins play a crucial role in regulating neuronal activity, with dysfunction implicated in various CNS diseases. Rapid glutamate uptake is essential for preventing toxic accumulation and ensuring efficient excitatory network activity.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Markus Leo, Linda-Isabell Schmitt, Rebecca Steffen, Andrea Kutritz, Christoph Kleinschnitz, Tim Hagenacker
Summary: The study found that platinum-based chemotherapeutics activate spinal astrocytes and decrease the expression of excitatory amino acid transporter 1. The modulation of K-ir4.1 and EAAT1 proteins in astrocytes may be linked to the direct impact of the chemotherapy drugs, identifying spinal astrocytes as a potential target in the prevention and treatment of chemotherapy-induced neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Longkuo Xia, Jianhuan Qi, Mingming Tang, Jing Liu, Da Zhang, Yanbing Zhu, Baoyang Hu
Summary: Continual deletion of microglia using pexidartinib reduces the production of collagen I and reforms the astrocyte scar, allowing for axon regeneration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Article
Clinical Neurology
Trong Dao Nguyen, Masaru Ishibashi, Adya Saran Sinha, Miho Watanabe, Daisuke Kato, Hiroshi Horiuchi, Hiroaki Wake, Atsuo Fukuda
Summary: This study investigated the role of astrocytic NKCC1 in modulating the postsynaptic action of GABA in acute seizure models. The results indicate that astrocytic NKCC1 inhibits the excitatory action of GABA during seizures, while neuronal NKCC1 has the opposite effect.
Article
Pharmacology & Pharmacy
Martin Machacek, Olga Svecova, Marketa Bebarova
Summary: The study found that sildenafil significantly inhibits IK1 at certain concentrations, and the inhibition effect is more pronounced when used in combination with Ba2+. This combined effect leads to a significant prolongation of action potential duration, potentially contributing to arrhythmias in patients treated with sildenafil.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Olga Tyurikova, Pei-Yu Shih, Yulia Dembitskaya, Leonid P. Savtchenko, Thomas J. McHugh, Dmitri A. Rusakov, Alexey Semyanov
Summary: Glutamatergic transmission through postsynaptic NMDA receptors induces K+ efflux, which enhances glutamate release in astrocytes and reduces glutamate uptake, forming a feedback loop.
Article
Cell Biology
Ines Belo do Nascimento, Marie Verfaillie, Gamze Ates, Pauline Beckers, Virginie Joris, Nathalie Desmet, Ann Massie, Emmanuel Hermans
Summary: Astrocytes in the central nervous system play a crucial role in energy homeostasis and metabolism support, with AMP-activated protein kinase (AMPK) being an important factor in helping cells adapt and maintain stable function under metabolic stress conditions.
Article
Biochemistry & Molecular Biology
Devin K. Binder, Christian Steinhaeuser
Summary: Changes in astrocyte channels, transporters, and metabolism are closely linked to seizure generation and epilepsy, with alterations in potassium, glutamate, water and adenosine homeostasis contributing to hyperexcitability and epileptogenesis. Understanding the role of astrocytes in epilepsy offers potential for identifying novel astrocyte-specific therapeutic targets.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Xiao Liu, Su-Su Tang, Si-Ming Liu, Jie Zeng, Zhi-Gang Chen, Cai-Hong Liu, Rong-Hao Mu, Dan-Hua Yuan, Jia-Jia Zhao, Hao Hong, Hao Wang
Summary: Astrocyte CysLT(1)R regulates depression through modulating glutamate synaptic transmission. This finding is of significant importance for developing novel drugs for depression treatment.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Immunology
Qi-Ming Pang, Si-Yu Chen, Qi-Jing Xu, Meng Zhang, Da-Fei Liang, Sheng-Ping Fu, Jiang Yu, Zu-Lin Liu, Qian Zhang, Tao Zhang
Summary: This study reviews the effects of neuroinflammation on SCI, with a focus on the contributions and interactions of microglia and astrocytes. It also discusses therapeutic strategies to regulate their immunophenotype in order to suppress inflammation and improve injury prognosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Anca Stoica, Brian Roland Larsen, Mette Assentoft, Rikke Holm, Leanne Melissa Holt, Frederik Vilhardt, Bente Vilsen, Karin Lykke-Hartmann, Michelle Lynne Olsen, Nanna MacAulay
Article
Neurosciences
Luke T. Stewart, Anas U. Khan, Kai Wang, Diana Pizarro, Sandipan Pati, Susan C. Buckingham, Michelle L. Olsen, John C. Chatham, Lori L. McMahon
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Michael Brenner, Albee Messing, Michelle L. Olsen
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Multidisciplinary Sciences
Bhanu P. Tewari, Lata Chaunsali, Susan L. Campbell, Dipan C. Patel, Adam E. Goode, Harald Sontheimer
NATURE COMMUNICATIONS
(2018)
Review
Biochemistry & Molecular Biology
Uri Kahanovitch, Kelsey C. Patterson, Raymundo Hernandez, Michelle L. Olsen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biology
Leanne M. Holt, Raymundo D. Hernandez, Natasha L. Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L. Olsen
Editorial Material
Cell Biology
Uri Kahanovitch, Michelle L. Olsen
JOURNAL OF CELL BIOLOGY
(2019)
Article
Neurosciences
Jessica L. Boni, Uri Kahanovitch, Sinifunanya E. Nwaobi, Candace L. Floyd, Michelle L. Olsen
Article
Neurosciences
Kelsey C. Patterson, Uri Kahanovitch, Christopher M. Goncalves, John J. Hablitz, Alexander Staruschenko, Daniel K. Mulkey, Michelle L. Olsen
Summary: Astrocyte heterogeneity is a concept where astrocytes show variable morphological and gene expression profiles within or between brain regions, with retrotrapezoid nucleus (RTN) astrocytes being sensitive to changes in CO2/H(+) levels. These RTN astrocytes respond to CO2/H(+) by inhibiting an inward rectifying potassium conductance and depolarizing the membrane, potentially affecting downstream chemoreceptive signaling events. Involvement of Kir5.1 channels in CO2/H(+) sensitivity in astrocytes suggests their importance in early developmental regional CO2/H(+) sensing.
Article
Clinical Neurology
Kristin F. Phillips, Harald Sontheimer
Summary: Neuroscience has expanded its presence in undergraduate education, offering students the opportunity to apply scientific knowledge to understand human behavior, interactions, sensations, emotions, and decision-making. This article encourages undergraduate neuroscience programs to embrace a broad view of the discipline, developing competencies relevant to various careers beyond research and medicine.
Article
Clinical Neurology
Lata Chaunsali, Bhanu P. Tewari, Harald Sontheimer
Summary: Perineuronal nets (PNNs) play a critical role in terminating neuroplasticity and regulating the inhibitory activity of GABAergic PV interneurons. Studies suggest their involvement in CNS diseases and epilepsy, with disruption of PNN associated with altered inhibition and seizure activity.
Article
Biochemical Research Methods
Michael R. Heaven, Anthony W. Herren, Daniel L. Flint, Natasha L. Pacheco, Jiangtao Li, Alice Tang, Fatima Khan, James E. Goldman, Brett S. Phinney, Michelle L. Olsen
Summary: In this study, a mouse model of Alexander disease (AxD) was analyzed to understand the molecular mechanisms of the disease. Upregulation of the glutathione metabolism pathway and peroxisome proliferator-activated receptor signaling pathway was observed in the AxD mice. The decreased levels of oligodendrocyte protein and myelin-associated proteins suggest the involvement of myelin synthesis in AxD. Fabp7 upregulation and its association with astrocyte proliferation and inhibition of the PPAR signaling pathway were also investigated.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Oncology
Robyn A. Umans, Joelle Martin, Megan E. Harrigan, Dipan C. Patel, Lata Chaunsali, Aarash Roshandel, Kavya Iyer, Michael D. Powell, Ken Oestreich, Harald Sontheimer
Summary: Glioblastoma multiforme (GBM) is a deadly brain tumor with limited treatment options. Recent research suggests that tumor protein 53 (TP53) is a molecular regulator of System xc- (SXC) in GBM, with its expression negatively correlated with xCT expression. This finding indicates that p53 may serve as a potential therapeutic target for GBM by regulating glutamate biology.
Article
Neurosciences
S. D. James, V. E. Hawkins, B. Falquetto, D. N. Ruskin, S. A. Masino, T. S. Moreira, M. L. Olsen, D. K. Mulkey
Article
Neurosciences
Uri Kahanovitch, Vishnu A. Cuddapah, Natasha L. Pacheco, Leanne M. Holt, Daniel K. Murphy, Alan K. Percy, Michelle L. Olsen