Cancer and diet: How are they related?

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanate

(2010) Violetta Krajka-Kuźniak et al.   BRITISH JOURNAL OF NUTRITION

Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-γ and COX-2-dependent signals

(2010) Shing Hwa Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nrf2–ARE signaling pathway and natural products for cancer chemoprevention

(2010) Cui Rong Zhao et al.   Cancer Epidemiology

Curcumin Inhibits Constitutive STAT3 Phosphorylation in Human Pancreatic Cancer Cell lines and Downregulation of Survivin/BIRC5 Gene Expression

(2010) W. Glienke et al.   CANCER INVESTIGATION

 -Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment

(2010) A. B. Kunnumakkara et al.   CANCER RESEARCH

Noscapine, a Benzylisoquinoline Alkaloid, Sensitizes Leukemic Cells to Chemotherapeutic Agents and Cytokines by Modulating the NF- B Signaling Pathway

(2010) B. Sung et al.   CANCER RESEARCH

Specific targeting of Wnt/ -catenin signaling in human melanoma cells by a dietary triterpene lupeol

(2010) R. S. Tarapore et al.   CARCINOGENESIS

Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation

(2010) Kyung Mi Lee et al.   CARCINOGENESIS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

(2010) P. Palozza et al.   CURRENT MEDICINAL CHEMISTRY

Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model

(2010) Nagarajan Sangeetha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phytoestrogen bavachin mediates anti-inflammation targeting IκB kinase-IκBα-NF-κB signaling pathway in chondrocytes in vitro

(2010) Cheng-Chung Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis

(2010) Suksanti Prakobwong et al.   INTERNATIONAL JOURNAL OF CANCER

Pterostilbene Inhibits Colorectal Aberrant Crypt Foci (ACF) and Colon Carcinogenesis via Suppression of Multiple Signal Transduction Pathways in Azoxymethane-Treated Mice

(2010) Yi-Siou Chiou et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Crotepoxide Chemosensitizes Tumor Cells through Inhibition of Expression of Proliferation, Invasion, and Angiogenic Proteins Linked to Proinflammatory Pathway

(2010) Sahdeo Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents

(2010) Ramaswamy Kannappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of β-catenin/Tcf signaling by flavonoids

(2010) Seyeon Park et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Curcumin Selectively Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines and Patients’ PBMCs: Potential Role for STAT-3 and NF-κB Signaling

(2010) Chunlei Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway

(2010) Haeyong Lee et al.   LIFE SCIENCES

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

(2010) Kuzhuvelil B. Harikumar et al.   MOLECULAR CANCER RESEARCH

5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization

(2010) S. K. Sandur et al.   MOLECULAR CANCER RESEARCH

Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds

(2010) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor- B Signaling Pathway

(2010) K. B. Harikumar et al.   MOLECULAR PHARMACOLOGY

NF-κB addiction and its role in cancer: ‘one size does not fit all’

(2010) M M Chaturvedi et al.   ONCOGENE

Cancer Chemopreventive Activity of Maslinic Acid: Suppression of COX-2 Expression and Inhibition of NF-κB and AP-1 Activation in Raji Cells

(2010) Yap Hsum et al.   PLANTA MEDICA

Anti-Inflammatory Plant Natural Products for Cancer Therapy

(2010) Kandan Aravindaram et al.   PLANTA MEDICA

Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells

(2010) H Y Choi et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid Metabolism

(2010) Tsuyoshi Goto et al.   PPAR Research

7-Chloroarctinone-b as a new selective PPARγ antagonist potently blocks adipocyte differentiation

(2009) Yong-tao Li et al.   ACTA PHARMACOLOGICA SINICA

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway

(2009) Bogdan Manolescu et al.   BIOCHIMIE

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer–Induced Bone Loss in Athymic Nude Mice

(2009) Bokyung Sung et al.   CANCER RESEARCH

Targeting Heat Shock Protein 90 Overrides the Resistance of Lung Cancer Cells by Blocking Radiation-Induced Stabilization of Hypoxia-Inducible Factor-1α

(2009) Woo-Young Kim et al.   CANCER RESEARCH

Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

(2009) Min-Hsiung Pan et al.   CARCINOGENESIS

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inflammation and cancer: how friendly is the relationship for cancer patients?

(2009) Bharat B Aggarwal et al.   CURRENT OPINION IN PHARMACOLOGY

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

(2009) Julia Bollrath et al.   EMBO REPORTS

Evaluation of anti-leukemia effect of resveratrol by modulating SATA3 signaling

(2009) Tan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells

(2009) Shigeki Ito et al.   LEUKEMIA RESEARCH

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines

(2009) M. A. Bill et al.   MOLECULAR CANCER THERAPEUTICS

Resveratrol and Piceatannol Inhibit iNOS Expression and NF-κ B Activation in Dextran Sulfate Sodium-Induced Mouse Colitis

(2009) Jin Youn et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Silibinin Suppresses Spontaneous Tumorigenesis in APC min/+ Mouse Model by Modulating Beta-Catenin Pathway

(2009) Subapriya Rajamanickam et al.   PHARMACEUTICAL RESEARCH

Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway

(2009) Haeyong Lee et al.   PHYTOTHERAPY RESEARCH

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PPAR-γAgonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer

(2009) A. Belfiore et al.   PPAR Research

Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana

(2008) Midori A. Arai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor- B-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor- B  kinase, leading to potentiation of apoptosis

(2008) B. Sung et al.   BLOOD

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD

Herbal Isoprenols Induce Apoptosis in Human Colon Cancer Cells Through Transcriptional Activation of PPARγ

(2008) Kathy Ka-Wai Au-Yeung et al.   CANCER INVESTIGATION

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Berberine Modifies Cysteine 179 of I B  Kinase, Suppresses Nuclear Factor- B-Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

(2008) M. K. Pandey et al.   CANCER RESEARCH

Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB–Regulated Gene Products and Potentiates Apoptosis

(2008) Preetha Anand et al.   CANCER RESEARCH

A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF- B-signaling pathways

(2008) Y. Suh et al.   CARCINOGENESIS

Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription

(2008) Takahiro Hosoya et al.   CHEMBIOCHEM

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Nuclear Factor-κB Activation: From Bench to Bedside

(2008) Gautam Sethi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells

(2008) Gerardo G. Mackenzie et al.   INTERNATIONAL JOURNAL OF CANCER

Deguelin inhibits retinal neovascularization by down-regulation of HIF-1α in oxygen-induced retinopathy

(2008) J. H. Kim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stat3 mediates myeloid cell–dependent tumor angiogenesis in mice

(2008) Maciej Kujawski et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a novel blocker of I B  kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor- B

(2008) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS

Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis

(2008) Gautam Sethi et al.   MOLECULAR CANCER THERAPEUTICS

Flavopiridol Suppresses Tumor Necrosis Factor-Induced Activation of Activator Protein-1, c-Jun N-Terminal Kinase, p38 Mitogen-Activated Protein Kinase (MAPK), p44/p42 MAPK, and Akt, Inhibits Expression of Antiapoptotic Gene Products, and Enhances Apoptosis through Cytochrome c Release and Caspase Activation in Human Myeloid Cells

(2008) Y. Takada et al.   MOLECULAR PHARMACOLOGY

Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1

(2008) M. K. Pandey et al.   MOLECULAR PHARMACOLOGY

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARγ

(2007) Gang Zou et al.   BIOCHEMICAL PHARMACOLOGY

Flavonoids induce HIF-1α but impair its nuclear accumulation and activity

(2007) Anastasia Triantafyllou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/β-catenin pathway

(2007) Rachana Patel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY