Review
Chemistry, Medicinal
Ali Aliabadi, Elham Khanniri, Mohammad Mahboubi-Rabbani, Maryam Bayanati
Summary: Dual cyclooxygenase 2/15-lipoxygenase inhibitors offer a valuable alternative for the treatment of inflammatory diseases and prevention of cancer, with reduced side effects compared to classical NSAIDs and selective COX-2 inhibitors. This review provides an overview of the COX-2 and 15-LOX pathways and discusses various structural families of dual inhibitors, paving the way for the design of potentially-active anticancer agents with balanced dual inhibition of these enzymes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Inorganic & Nuclear
Huzaifa Yasir Khan, Sabiha Parveen, Imtiyaz Yousuf, Sartaj Tabassum, Farukh Arjmand
Summary: Metal complexes of non-steroidal anti-inflammatory drugs (NSAIDs) have gained attention in anti-tumor drug therapy. By selecting suitable metal ions and coordination geometries, NSAID-metal conjugates can be fine-tuned for targeted therapies. Metal complexes exhibit intriguing behavior in vivo, interacting with intracellular molecules and targeting cancer cells, thus playing a significant role in cell inhibition processes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Saad R. El-Zemity, Rasha A. Nassra, Marwa M. Abu-Serie, Aly A. Hazzaa
Summary: The study aimed to combat CRC by synthesizing and evaluating new thymol - 4-thiazolidinone hybrids as multitarget anticancer agents that could inhibit the key COX-2, 5-LOX and PIM-1 kinase enzymes simultaneously. Compound 5g showed the most promising results, inhibiting three key targets leading to inhibition of human CRC cell proliferation both in vitro and in vivo.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, General & Internal
Nadine Ansorge, Christian Dannecker, Udo Jeschke, Elisa Schmoeckel, Doris Mayr, Helene H. Heidegger, Aurelia Vattai, Maximiliane Burgmann, Bastian Czogalla, Sven Mahner, Sophie Fuerst
Summary: The study found that the expression of COX-2 and PPAR gamma in vulvar cancer tissues is associated with survival rate, with cytoplasmic expression leading to reduced survival and nuclear expression associated with better survival. The combined expression of both COX-2 and PPAR gamma in the cytoplasm is considered an independent negative prognostic factor for vulvar cancer patients.
Article
Endocrinology & Metabolism
Dongliang Fang, Xinyi Shi, Xiaowei Jia, Chun Yang, Lulu Wang, Baopu Du, Tao Lu, Lin Shan, Yan Gao
Summary: The research reveals that FSTL1 promotes adipogenesis through the integrin/FAK/ERK signaling pathway, with glycosylated modification at the N142 site playing a key role. Lack of FSTL1 inhibits preadipocyte differentiation and obesity development.
MOLECULAR METABOLISM
(2022)
Article
Chemistry, Medicinal
Nora M. Aborehab, Mahitab H. El Bishbishy
Summary: The potential of mango, orange, cantaloupe, and pomegranate fruit peels in treating osteoarthritis was evaluated. The study found that these extracts can significantly reduce inflammation and oxidative stress, and protect cartilage. Mango peel extract exhibited the best chondroprotective effect.
ARCHIV DER PHARMAZIE
(2022)
Article
Medicine, Research & Experimental
Qi-Yue Chen, Xiao-Bo Huang, Ya-Jun Zhao, Hua-Gen Wang, Jia-Bin Wang, Li-Chao Liu, Ling-Qian Wang, Qing Zhong, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Chang-Ming Huang
Summary: This study identified a decrease in FABP4 expression as a potential marker for gastric cancer (GC) metastasis and poor prognosis. Mechanistically, FABP4 inhibited GC metastasis by binding with PPAR-gamma and suppressing CADM3 transcription. The antidiabetic drug rosiglitazone showed therapeutic potential in restoring PPAR-gamma/CADM3 activation in FABP4-deficient GC cells.
Article
Cell Biology
Lu Wang, Junping Wang
Summary: Ulcerative colitis (UC) is a intestinal disease, and honokiol (HKL) can relieve UC by exerting anti-inflammatory, antioxidant, and epithelial barrier enhancement effects, making it a promising drug.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Immunology
Nan Wang, Rui Kong, Wei Han, Wen Bao, Yihai Shi, LiPing Ye, Jie Lu
Summary: This study investigated the suppressive effect of honokiol on UC and its regulatory mechanism. The results showed that honokiol significantly attenuated the severity of UC by reducing inflammatory signals and restoring colon integrity. Honokiol suppressed the expression of proinflammatory cytokines, upregulated PPAR-γ expression, downregulated TLR4-NF-κB signaling, and inhibited cell pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Dandan Wu, Dianna Spilca, Que Le, Xin Yang, Katelyn Alvarez, William Curtis Hines, Xuexian O. Yang, Meilian Liu
Summary: The lack of COX-2 in adipocytes promotes white adipose tissue development and increases the size and number of adipocytes, leading to obesity and insulin resistance. Treatment with PGE2 can reverse the increased size and number of adipocytes caused by COX-2 knockout.
Article
Cell Biology
Sami G. Alsabri, Gadid G. Guedi, Mehdi Najar, Makram Merimi, Frederic Lavoie, Detlev Grabs, Julio Fernandes, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
Summary: The expression level of 15-LOX-1 is elevated in osteoarthritis (OA) cartilage, but it is not associated with the methylation status of its promoter.
INFLAMMATION RESEARCH
(2023)
Article
Cell Biology
Roua Chaabani, Mohamed Bejaoui, Ikram Ben Jeddou, Mohamed Amine Zaouali, Zohra Haouas, Sameh Belgacem, Carmen Peralta, Hassen Ben Abdennebi
Summary: This study found that diclofenac has beneficial effects on hepatic ischemia/reperfusion injury (IRI) by reducing oxidative stress, inflammation, and apoptosis. It activates the eNOS pathway, which contributes to its protective effects.
Article
Chemistry, Medicinal
Amany M. Ghanim, Samar Rezq, Tarek S. Ibrahim, Damian G. Romero, Hend Kothayer
Summary: Novel 1,2,4-triazine-quinoline hybrids were designed and synthesized as dual COX/15-LOX inhibitors, with hybrid 8e exhibiting the most potent and selective inhibitory activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Vaikundamoorthy Ramalingam, Inho Hwang
Summary: The study demonstrated that ZVZ nanoparticles can effectively induce adipogenesis and increase lipid accumulation in 3T3-L1 cells, while regulating cell differentiation by upregulating the expression of key genes.
PROCESS BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mehrdad Aghasizadeh, Tayebe Moghaddam, Ahmad Reza Bahrami, Hamid Sadeghian, Seyed Jamal Alavi, Maryam M. Matin
Summary: Carbostyril derivatives have been found to inhibit the growth of prostate cancer cells. These compounds effectively inhibit 15-LOX activity and induce cytotoxicity in prostate cancer cells through apoptosis. In vivo studies show that 8-GQ has stronger anti-tumor effects and fewer side effects on normal tissues compared to cisplatin.
Article
Cell Biology
Sheng-Mao Wu, Yee-Jee Jan, Shih-Chuan Tsai, Hung-Chuan Pan, Chin-Chang Shen, Cheng-Ning Yang, Shu-Hua Lee, Shing-Hwa Liu, Li-Wei Shen, Chien-Shan Chiu, Jack L. Arbiser, Menghsiao Meng, Meei-Ling Sheu
Summary: This study found that Honokiol can prevent the metastatic dissemination of gastric cancer cells by inhibiting HDAC3 activity/expression. The results suggest that Honokiol inhibits HDAC3 activity by suppressing the activation of the NF-Bp65/CEBPβ signaling pathway, thereby inhibiting the migration and invasion of cancer cells. In addition, Honokiol increases the expression of ER stress markers, inhibits the expression of EMT-associated epithelial markers, and decreases Wnt/β-catenin activity, thereby blocking the metastasis of gastric cancer.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Toxicology
Yao-Pang Chung, Te- Weng, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: This study found that TBT exposure can induce human chondrocyte senescence and accelerate mouse articular cartilage aging. TBT affects signaling pathways and has an impact on cell secretory phenotype, leading to changes in protein expression and mRNA expression.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Immunology
He-Hsiung Cheng, Lin Hung-Ke, Meei-Ling Sheu, Chun-Yi Lee, Yi-Ching Tsai, De-Wei Lai
Summary: The study investigates the regulatory mechanism of the AHR/TET2/NT5E pathway during SLE progression. The expression levels of AHR, TET2, and NT5E were examined in Tregs of SLE patients. The study found that AHR and TET2 expression levels were correlated with the immunosuppressive functions of Tregs. In addition, KYN promoted the binding of AHR to the TET2 promoter, leading to downregulation of NT5E expression in Tregs of SLE patients. Furthermore, the study showed that the Treg immunosuppressive activity was enhanced in the KYN-treated group through the TET2 and A2AR-adenosine pathways.
Article
Geriatrics & Gerontology
Hsien-Chun Chiu, Rong-Sen Yang, Te- Weng, Chen-Yuan Chiu, Kuo-Cheng Lan, Shing-Hwa Liu
Summary: This study demonstrates the significant inhibitory effects of low-dose TBT on myogenic differentiation and induction of myotube atrophy. It also shows that TBT exposure decreases muscle regeneration ability, reduces muscle mass and impairs muscle function. These findings suggest that low-dose TBT may be an environmental risk factor for muscle regeneration inhibition, atrophy/wasting, and disease-related myopathy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Toxicology
Ting-Yu Chang, Kuo-Cheng Lan, Chia-Hung Wu, Meei-Ling Sheu, Rong-Sen Yang, Shing-Hwa Liu
Summary: Despite limited discussion, diabetes mellitus is considered a risk factor for primary bone cancer. In this study, it was found that hyperglycemia affects the stemness and malignancy of chondrosarcoma cells. Furthermore, it was discovered that the advanced glycation end product CML enhances chondrosarcoma stemness and metastasis.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Li-Cheng Ku, Meei-Ling Sheu, He-Hsiung Cheng, Chun-Yi Lee, Yi-Ching Tsai, Chia-Yun Tsai, Keng-Hung Lin, Lih-Ching Lai, De-Wei Lai
Summary: Age-related macular degeneration is a major cause of visual deficiency in older adults worldwide. Melatonin may reduce retinal deterioration by mediating regulatory T cells in the retina. The study found that melatonin effectively restored retinopathy and maintained retinal structural integrity. It also promoted tissue repair by increasing the infiltration of regulatory T cells and upregulating TET2 and NT5E expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Shin Song, Tai-Ho Hung, Shing-Hwa Liu, Yin-Ting Zheng, Hsin-Mei Lin, Feng-Yi Yang
Summary: Systemic inflammation is linked to intestinal inflammation and neuroinflammation through the gut-brain axis. Low-intensity pulsed ultrasound (LIPUS) has neuroprotective and anti-inflammatory effects. This study demonstrates that abdominal LIPUS stimulation attenuates LPS-induced colonic inflammation and neuroinflammation, offering new insights into the treatment of neuroinflammation-related brain disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hao-Chun Chang, Weir Chiang You, Chiung-Chyi Shen, Ying Ju Chen, Ming-His Sun, Meei-Ling Sheu, Liang-Yi Pan, Jason Sheehan, Kuo-Chih Su, Hung-Chuan Pan
Summary: This study aimed to use automated volumetric analysis software to quantify the degree of brain stem deformity and predict the long-term outcomes of patients with large vestibular schwannomas (VS) following Gamma Knife radiosurgery (GKRS). The study found that patients with smaller tumor volumes, lower vital structure deformity indices, and a longer distance of the tumor to the central line were more likely to have favorable clinical outcomes after GKRS. The brainstem deformity ratio is likely a useful index to assess the clinical and tumor regression outcomes.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Chen-Yu Lin, Te- Weng, Jui-Zhi Loh, Ding-Cheng Chan, Chih-Kang Chiang, Kuan-Yu Hung, Shing-Hwa Liu
Summary: Low-intensity pulsed ultrasound (LIPUS) is a therapeutic ultrasound that can aid in bone fracture repair and soft tissue healing. This study aimed to investigate the protective potential of LIPUS on CKD-associated muscle wasting. The results showed that LIPUS treatment effectively improved muscle strength, prevented muscle mass loss, and reduced muscle atrophy-related protein expression in CKD mice.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Infectious Diseases
Feng-Chen Chen, Ahmad Khaldun Ismail, Yan-Chiao Mao, Chih-Hsiung Hsu, Liao-Chun Chiang, Chang-Chih Shih, Yuan-Sheng Tzeng, Chin-Sheng Lin, Shing-Hwa Liu, Cheng-Hsuan Ho
Summary: Snakebite patients bitten by Protobothrops mucrosquamatus commonly experience pain, swelling and blister formation. The effectiveness of FHAV in treating local tissue injury is still uncertain. A study conducted from 2017 to 2022 found that patients with greater swelling and higher severity received higher doses of FHAV and had longer remission times. The study also suggested that monitoring the deceleration of swelling progression can help clinicians decide on FHAV administration.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Meei-Ling Sheu, Liang-Yi Pan, Cheng-Ning Yang, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Hung-Chuan Pan
Summary: Thrombin is closely related to neurodegenerative disorders, and AhR is well expressed in microglia cells involved in inflammatory disorders of the brain. This study found that deleting AhR aggravated the inflammatory response and neurodegenerative processes induced by thrombin in microglia cells, while an AhR agonist could inhibit these responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Meei-Ling Sheu, Liang-Yi Pan, Cheng-Ning Yang, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Hong-Shiu Chen, Hung-Chuan Pan
Summary: This study reveals, for the first time, the mechanisms underlying microglial activation and neuroinflammatory response following thrombin-induced brain damage, highlighting the crucial role of HMGB1 in this process, and it is found that anti-HMGB1 antibodies can alleviate the damage. This has significant implications for understanding the pathogenesis of thrombin-associated neurodegenerative disorders and identifying new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Li-Ting Tsai, Te- Weng, Ting-Yu Chang, Kuo-Cheng Lan, Chih-Kang Chiang, Shing-Hwa Liu
Summary: The accumulation of the uremic toxin indoxyl sulfate (IS) is a key pathological feature of chronic kidney disease (CKD). Exposure to IS can induce ferroptosis, characterized by iron accumulation, impaired antioxidant system, elevated reactive oxygen species (ROS) levels, and lipid peroxidation. IS triggers intracellular iron accumulation and ROS generation, leading to the induction of ferroptosis, senescence, ER stress, and injury/fibrosis in CKD kidneys.