期刊
JOURNAL OF INFECTIOUS DISEASES
卷 207, 期 2, 页码 213-222出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis663
关键词
HIV-1; interferon-alpha; viral integration; immunotherapy
资金
- National Institutes of Health
- NIH/NIAID [U01AI065279, K08AI073102, K02 AI078766, R21 AI087461]
- Genentech/Roche [PEG224]
- Philadelphia Foundation (Robert I. Jacobs Fund)
- Commonwealth of Pennsylvania
- Commonwealth Universal Research Enhancement Program
- Pennsylvania Department of Health
- Penn Center for AIDS Research [P30 AI 045008]
- Cancer Center Grant [P30 CA10815]
- American Foundation for AIDS Research
- National Cancer Institute
- National Institutes of Health [HHSN261200800001E]
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
Background. Antiretroviral therapy (ART)-mediated immune reconstitution fails to restore the capacity of the immune system to spontaneously control human immunodeficiency virus (HIV) replication. Methods. A total of 23 HIV type 1 (HIV-1)-infected, virologically suppressed subjects receiving ART (CD4(+) T-cell count, >450 cells/mu L) were randomly assigned to have 180 mu g/week (for arm A) or 90 mu g/week (for arm B) of pegylated (Peg) interferon alfa-2a added to their current ART regimen. After 5 weeks, ART was interrupted, and Peg-interferon alfa-2a was continued for up to 12 weeks (the primary end point), with an option to continue to 24 weeks. End points included virologic failure (viral load, >= 400 copies/mL) and adverse events. Residual viral load and HIV-1 DNA integration were also assessed. Results. At week 12 of Peg-interferon alfa-2a monotherapy, viral suppression was observed in 9 of 20 subjects (45%), a significantly greater proportion than expected (arm A, P = .0088; arm B, P = .0010; combined arms, P < .0001). Over 24 weeks, both arms had lower proportions of subjects who had viral load, compared with the proportion of subjects in a historical control group (arm A, P = .0046; arm B, P = .0011). Subjects who had a sustained viral load of < 400 copies/mL had decreased levels of integrated HIV DNA (P = .0313) but increased residual viral loads (P = .0078), compared with subjects who experienced end-point failure. Conclusions. Peg-interferon alfa-2a immunotherapy resulted in control of HIV replication and decreased HIV-1 integration, supporting a role for immunomediated approaches in HIV suppression and/or eradication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据