Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations

Antifungal use in hospitalized adults in U.S. academic health centers

(2011) A. L. Pakyz et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Combination Therapy of Murine Mucormycosis or Aspergillosis with Iron Chelation, Polyenes, and Echinocandins

(2011) Ashraf S. Ibrahim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America

(2011) Alison G. Freifeld et al.   CLINICAL INFECTIOUS DISEASES

The economic costs to United States hospitals of invasive fungal infections in transplant patients

(2010) Joseph Menzin et al.   AMERICAN JOURNAL OF INFECTION CONTROL

In Vitro Profiling of Pramiconazole and In Vivo Evaluation in Microsporum canis Dermatitis and Candida albicans Vaginitis Laboratory Models

(2010) K. de Wit et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antifungal Activities of Isavuconazole and Comparators against Rare Yeast Pathogens

(2010) J. Guinea et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-2307 Shows Efficacy in a Murine Model of Candida glabrata Infection despite In Vitro Trailing Growth Phenomena

(2010) E. Yamada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Ravuconazole Treatment on Parasite Load and Immune Response in Dogs Experimentally Infected with Trypanosoma cruzi

(2010) L. d. F. Diniz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Systematic Review and Meta-Analysis of the Tolerability and Hepatotoxicity of Antifungals in Empirical and Definitive Therapy for Invasive Fungal Infection

(2010) J. L. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antifungal Susceptibilities and Amplified Fragment Length Polymorphism Genotyping of a Worldwide Collection of 350 Clinical, Veterinary, and Environmental Cryptococcus gattii Isolates

(2010) F. Hagen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001–2006: Overview of the Transplant‐Associated Infection Surveillance Network (TRANSNET) Database

(2010) Dimitrios P. Kontoyiannis et al.   CLINICAL INFECTIOUS DISEASES

Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant‐Associated Infection Surveillance Network (TRANSNET)

(2010) Peter G. Pappas et al.   CLINICAL INFECTIOUS DISEASES

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

(2010) John R. Perfect et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimicrobial Surveillance Program (2009)

(2010) Michael A. Pfaller et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Randomized, Comparative, Double-Blind, Double-Dummy, Multicenter Trial of Miconazole Buccal Tablet and Clotrimazole Troches for the Treatment of Oropharyngeal Candidiasis: Study of Miconazole Lauriad®Efficacy and Safety (SMiLES)

(2010) José A. Vazquez et al.   HIV CLINICAL TRIALS

In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan

(2010) Toshikazu Yamazaki et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Nationwide Austrian Aspergillus Registry: a prospective data collection on epidemiology, therapy and outcome of invasive mould infections in immunocompromised and/or immunosuppressed patients

(2010) S. Perkhofer et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Emerging invasive zygomycosis in a tertiary care center: epidemiology and associated risk factors

(2010) Juan Ambrosioni et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Prevalence and Treatment Management of Oropharyngeal Candidiasis in Cancer Patients: Results of the French Candidoscope Study

(2010) Joseph Gligorov et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Echinocandin pharmacodynamics: review and clinical implications

(2010) M. W. Pound et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Use of Epidemiological Cutoff Values To Examine 9-Year Trends in Susceptibility of Candida Species to Anidulafungin, Caspofungin, and Micafungin

(2010) M. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Safety and Pharmacokinetics of Higher Doses of Caspofungin in Healthy Adult Participants

(2010) Elizabeth M. Migoya et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Targeted brain delivery of itraconazole via RVG29 anchored nanoparticles

(2010) Wei Chen et al.   JOURNAL OF DRUG TARGETING

Voriconazole exposure and geographic location are independent risk factors for squamous cell carcinoma of the skin among lung transplant recipients

(2010) Aniket Vadnerkar et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Candida albicansHyr1p Confers Resistance to Neutrophil Killing and Is a Potential Vaccine Target

(2010) Guanpingsheng Luo et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent Photopsia Following Course of Oral Voriconazole

(2010) Huseyin Kadikoy et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Successful Treatment of Life-threatening Candida Peritonitis in a Child With Abdominal Non-Hodgkin Lymphoma Using Efungumab and Amphotericin B Colloid Dispersion

(2010) Zdenka Krenova et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Antifungal susceptibility, serotyping, and genotyping of clinicalCryptococcus neoformansisolates collected during 18 years in a single institution in Madrid, Spain

(2010) Jesús Guinea et al.   MEDICAL MYCOLOGY

Developing a vaccine against aspergillosis

(2010) David A. Stevens et al.   MEDICAL MYCOLOGY

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients

(2010) D. Neofytos et al.   Transplant Infectious Disease

Beta-glucan-CRM197 conjugates as candidates antifungal vaccines

(2010) Carla Bromuro et al.   VACCINE

Mortality, length of hospitalization, and costs associated with invasive fungal infections in high-risk patients

(2009) J. Menzin et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Efficacy of Albaconazole against Candida albicans in a Vaginitis Model

(2009) G. M. Gonzalez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of Mild and Moderate Liver Disease on the Pharmacokinetics of Isavuconazole after Intravenous and Oral Administration of a Single Dose of the Prodrug BAL8557

(2009) A. Schmitt-Hoffmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics of Nikkomycin Z after Single Rising Oral Doses

(2009) D. E. Nix et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus

(2009) K. A. Zarember et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of Isavuconazole against Aspergillus Species and Zygomycetes According to the Methodology of the European Committee on Antimicrobial Susceptibility Testing

(2009) S. Perkhofer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Pharmacodynamics of a Novel Triazole, Isavuconazole: Mathematical Modeling, Importance of Tissue Concentrations, and Impact of Immune Status on Antifungal Effect

(2009) P. A. Warn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

FR290581, a novel sordarin derivative: Synthesis and antifungal activity

(2009) Tadaatsu Hanadate et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Empirical versus Preemptive Antifungal Therapy for Fever during Neutropenia

(2009) Kieren A. Marr et al.   CLINICAL INFECTIOUS DISEASES

Omeprazole Significantly Reduces Posaconazole Serum Trough Level

(2009) Jan‐Willem C. Alffenaar et al.   CLINICAL INFECTIOUS DISEASES

A Multicenter, Double‐Blind Trial of a High‐Dose Caspofungin Treatment Regimen versus a Standard Caspofungin Treatment Regimen for Adult Patients with Invasive Candidiasis

(2009) Robert F. Betts et al.   CLINICAL INFECTIOUS DISEASES

Empirical versus Preemptive Antifungal Therapy for High‐Risk, Febrile, Neutropenic Patients: A Randomized, Controlled Trial

(2009) Catherine Cordonnier et al.   CLINICAL INFECTIOUS DISEASES

The role of iron and iron chelators in zygomycosis

(2009) A.S. Symeonidis   CLINICAL MICROBIOLOGY AND INFECTION

Overview of Antifungal Agents

(2009) George R. Thompson et al.   CLINICS IN CHEST MEDICINE

New generation azole antifungals in clinical investigation

(2009) Corrado Girmenia   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus

(2009) Peter A. Warn et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In vitro activity of isavuconazole against Trichosporon, Rhodotorula, Geotrichum, Saccharomyces and Pichia species

(2009) G. R. Thompson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis

(2009) A. S. Ibrahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens

(2009) M. A. Pfaller et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network

(2009) J. W. Baddley et al.   JOURNAL OF CLINICAL MICROBIOLOGY

In Vitro Activity of Seven Systemically Active Antifungal Agents against a Large Global Collection of Rare Candida Species as Determined by CLSI Broth Microdilution Methods

(2009) D. J. Diekema et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A safety and feasibility study comparing an intermittent high dose with a daily standard dose of liposomal amphotericin B for persistent neutropenic fever

(2009) M. Ellis et al.   JOURNAL OF MEDICAL MICROBIOLOGY

A double-blind, randomized, placebo-controlled, dose-finding study of oral pramiconazole in the treatment of pityriasis versicolor

(2009) Jan Faergemann et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Combined antifungal therapy, iron chelation and surgical resection as treatment of hepatic zygomycosis in a patient with haematological malignancy

(2009) Alessandro Busca et al.   MYCOSES

Treatment of a critically ill child with disseminated Candida glabrata with a recombinant human antibody specific for fungal heat shock protein 90 and liposomal amphotericin B, caspofungin, and voriconazole

(2009) Adam Sutherland et al.   Pediatric Critical Care Medicine

Protection by Anti-β-Glucan Antibodies Is Associated with Restricted β-1,3 Glucan Binding Specificity and Inhibition of Fungal Growth and Adherence

(2009) Antonella Torosantucci et al.   PLoS One

Saccharomyces cerevisiae as a vaccine against coccidioidomycosis

(2009) Javier Capilla et al.   VACCINE

A β-glucan-conjugate vaccine and anti-β-glucan antibodies are effective against murine vaginal candidiasis as assessed by a novel in vivo imaging technique

(2009) Donatella Pietrella et al.   VACCINE

Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice

(2009) Lin Lin et al.   PLoS Pathogens

Efficacy of a Single Oral Dose of 200 mg Pramiconazole in Vulvovaginal Yeast Infections: An Exploratory Phase IIa Trial

(2008) G Donders et al.   ACTA DERMATO-VENEREOLOGICA

Clinical Application of Voriconazole Concentrations in the Treatment of Invasive Aspergillosis

(2008) Ashley Howard et al.   ANNALS OF PHARMACOTHERAPY

Complexity of Interactions Between Voriconazole and Antiretroviral Agents

(2008) Erin M Yakiwchuk et al.   ANNALS OF PHARMACOTHERAPY

Efficacy of SPK-843, a Novel Polyene Antifungal, in Comparison with Amphotericin B, Liposomal Amphotericin B, and Micafungin against Murine Pulmonary Aspergillosis

(2008) H. Kakeya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of SPK-843, a Novel Polyene Antifungal, in a Murine Model of Systemic Cryptococcosis

(2008) H. Kakeya et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Failure of Deferasirox, an Iron Chelator Agent, Combined with Antifungals in a Case of Severe Zygomycosis

(2008) A. Soummer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of the New Azole Isavuconazole (BAL4815) Compared with Six Other Antifungal Agents against 162 Cryptococcus neoformans Isolates from Cuba

(2008) M.-T. Illnait-Zaragozi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro and In Vivo Antifungal Activities of T-2307, a Novel Arylamidine

(2008) J. Mitsuyama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antifungal Activities of Isavuconazole (BAL4815), Voriconazole, and Fluconazole against 1,007 Isolates of Zygomycete, Candida, Aspergillus, Fusarium, and Scedosporium Species

(2008) J. Guinea et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT

(2008) H Hebart et al.   BONE MARROW TRANSPLANTATION

The efficacy of oral treatment with pramiconazole in tinea pedis and tinea cruris/corporis: two exploratory phase IIa trials

(2008) J. Decroix et al.   BRITISH JOURNAL OF DERMATOLOGY

Pharmacokinetics, Safety and Tolerance of Voriconazole in Renally??Impaired Subjects

(2008) Samantha Abel et al.   CLINICAL DRUG INVESTIGATION

Unknown

(2008)   CLINICAL INFECTIOUS DISEASES

Hallucinations during Voriconazole Therapy

(2008) Dimitrios I. Zonios et al.   CLINICAL INFECTIOUS DISEASES

High‐Dose Amphotericin B with Flucytosine for the Treatment of Cryptococcal Meningitis in HIV‐Infected Patients: A Randomized Trial

(2008) Tihana Bicanic et al.   CLINICAL INFECTIOUS DISEASES

Defining Responses to Therapy and Study Outcomes in Clinical Trials of Invasive Fungal Diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer Consensus Criteria

(2008) Brahm H. Segal et al.   CLINICAL INFECTIOUS DISEASES

Editorial Commentary:What is the Role of Combination Therapy in Management of Zygomycosis?

(2008) Thomas J. Walsh et al.   CLINICAL INFECTIOUS DISEASES

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

(2008) Ben De Pauw et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology and Outcome of Invasive Fungal Infection in Adult Hematopoietic Stem Cell Transplant Recipients: Analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance Registry

(2008) D. Neofytos et al.   CLINICAL INFECTIOUS DISEASES

Therapeutic and prophylactic efficacy of aminocandin (IP960) against disseminated candidiasis in mice

(2008) L.K. Najvar et al.   CLINICAL MICROBIOLOGY AND INFECTION

Secular Trends in Candidemia-Related Hospitalization in the United States, 2000–2005

(2008) Marya D. Zilberberg et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Safety of a weekly high dose of liposomal amphotericin B for prophylaxis of invasive fungal infection in immunocompromised patients: PROPHYSOME Study

(2008) Catherine Cordonnier et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Development and evaluation of novel itraconazole-loaded intravenous nanoparticles

(2008) Wei Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efungumab and caspofungin: pre-clinical data supporting synergy

(2008) S. Hodgetts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B

(2008) H. Sandovsky-Losica et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei

(2008) J. Majithiya et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility

(2008) G. E. Brzankalski et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods

(2008) A. Alastruey-Izquierdo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Trends in Species Distribution and Susceptibility of Bloodstream Isolates of Candida Collected in Monterrey, Mexico, to Seven Antifungal Agents: Results of a 3-Year (2004 to 2007) Surveillance Study

(2008) G. M. Gonzalez et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Fungal vaccines: real progress from real challenges

(2008) Antonio Cassone   LANCET INFECTIOUS DISEASES

In vitroactivities of isavuconazole against opportunistic filamentous and dimorphic fungi

(2008) Gloria M. González   MEDICAL MYCOLOGY

Antifungal agents – clinical pharmacokinetics and drug interactions

(2008) Hans-Peter Lipp   MYCOSES

Current Options in Antifungal Pharmacotherapy

(2008) John Mohr et al.   PHARMACOTHERAPY

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

(2007) Z. A. Kanafani et al.   CLINICAL INFECTIOUS DISEASES

New and emerging treatments for fungal infections

(2007) A. C. Pasqualotto et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Amphotericin B Formulations and Drug Targeting

(2007) J.J. Torrado et al.   JOURNAL OF PHARMACEUTICAL SCIENCES