Article
Pharmacology & Pharmacy
Maryam Rasool, Danish Mazhar, Iqra Afzal, Ahmad Zeb, Salman Khan, Hussain Ali
Summary: This study aimed to develop Miconazole Nitrate transethosomes (MCZN TESs) embedded in chitosan-based gel for the treatment of Cutaneous Candidiasis. The optimized MCZN TESs showed small particle size, high entrapment efficiency, sustained drug release, and improved penetration and deposition capabilities compared to MCZN TESs alone. The in vitro and in vivo experiments demonstrated the superior antifungal activity and reduced treatment duration of MCZN TESs Gel. This study highlights the potential of MCZN TESs as an effective drug delivery system for topical treatment of Cutaneous Candidiasis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Giuseppina Berlingieri, Cristina Maria Arvate Alvares, Rafael Verardi Serrano, Luiz Felipe Palma, Luana Campos
Summary: Opportunistic oral infections in COVID-19 patients are addressed in this study, which presents a case where a combination of antimicrobial photodynamic therapy and photobiomodulation therapy was used for management. All lesions resolved completely within 7 days without any systemic drug administration, indicating the potential of these phototherapy modalities in managing viral and fungal opportunistic oral infections.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Pharmacology & Pharmacy
Jorge Alves-Silva, Monica Zuzarte, Carlos Cavaleiro, Ligia Salgueiro
Summary: Fungal infections are prevalent with high morbidity and mortality rates, especially in patients with underlying health complications. Plant-based antifungal products show promise in mitigating these infections, and Lavandula multifida essential oil has been found to have strong inhibitory and disruptive effects on fungal biofilms. The oil significantly decreased biofilm mass and viability, and induced morphological alterations in fungal biofilms, making it a potential candidate for the development of effective antifungal products.
Article
Pharmacology & Pharmacy
Sarah A. Ali, Amal M. Sindi, Yasmin H. Mair, Rasha A. Khallaf
Summary: The optimized MIC-ET-AXHc oral gel base formulation showed superior antifungal activity and improved ulcer healing properties, indicating potential for effective treatment of oral thrush infections. The combination of carrier vesicles and gelling agents resulted in enhanced membrane permeability, antifungal activity, and healing of mouth ulcers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Yee Shen Loo, Tse Yee Wong, Sajesh K. Veettil, Pei Se Wong, Divya Gopinath, Siew Mooi Ching, Rohit Kunnath Menon
Summary: Clotrimazole is the most effective agent for preventing oral candidiasis, while fluconazole has the best safety profile among other antifungal agents. However, due to the lack of studies comparing clotrimazole with other antifungal agents, we are unable to recommend it as the best choice for preventing oral candidiasis.
Article
Infectious Diseases
Yufeng Wang, Haiwen Zhou, Wenmei Wang, Ning Duan, Zhixiao Luo, Hongbo Chai, Lu Jiang, Qianming Chen, Jinli Liu, Hong Hua, Zhimin Yan, Yuan Fan, Juanyong Xu, Xiaobing Guan, Hongjian Wang, Hongzhou Lu, Wenhui Lun, Wei Fei, Tong Zhang, Jizhi Zhao, Chunling Jia, Hui Kong, Xuemin Shen, Qing Liu, Weizhi Wang, Guoyao Tang
Summary: The study found that once-daily treatment with miconazole buccal tablets is as effective as systemic itraconazole capsules in Chinese patients with oropharyngeal candidiasis, and it has minimal side effects.
Review
Microbiology
Shamala Gopal Rajadurai, Mari Kannan Maharajan, Sajesh K. Veettil, Divya Gopinath
Summary: This study compared the efficacy and safety of different antifungal agents in treating oropharyngeal candidiasis (OPC) in HIV-infected adults through network meta-analysis. Fluconazole was found to be the most effective treatment, followed by posaconazole and itraconazole, while nystatin was deemed the safest option.
Article
Polymer Science
Nutdanai Lertsuphotvanit, Sarun Tuntarawongsa, Kritamorn Jitrangsri, Thawatchai Phaechamud
Summary: Oral candidiasis refers to fungal infections in the mouth, and this research evaluated the use of borneol as a matrix-forming agent in a clotrimazole-loaded gel. The gel exhibited appropriate physicochemical properties and controlled drug release. It also showed efficient inhibition of growth against various microorganisms. Therefore, the gel has great potential as a drug delivery system for the localized treatment of oropharyngeal candidiasis.
Review
Pharmacology & Pharmacy
Dan Cristian Gheorghe, Adelina-Gabriela Niculescu, Alexandra Catalina Birca, Alexandru Mihai Grumezescu
Summary: This paper focuses on the newest therapeutic options against oral Candida infections, including compounds and biomaterials with inherent antifungal properties, improved materials for dental prostheses and denture adhesives, drug delivery systems, and combined approaches towards developing the optimum treatment. Novel treatments have to be developed and implemented in clinical practice to address the severe adverse effects often associated with traditional antifungal agents.
Article
Obstetrics & Gynecology
R. Sobel, P. Nyirjesy, M. A. Ghannoum, D. A. Delchev, N. E. Azie, D. Angulo, I. A. Harriott, K. Borroto-Esoda, J. D. Sobel
Summary: Ibrexafungerp has demonstrated statistical superiority over placebo in treating acute vulvovaginal candidiasis, with significantly higher rates of clinical cure, mycological eradication, overall success, and symptom resolution. It is a promising and effective one-day treatment for this condition.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ksenia Drozd, Alex N. Manin, Denis E. Boycov, German L. Perlovich
Summary: This study demonstrates that the preparation method of multicomponent crystals significantly affects the solid-state characteristics and physicochemical properties of miconazole. Lyophilization promotes partial amorphization and allows the formation of a new polymorph, but stability issues are observed. In vivo studies show that multicomponent crystals enhance the oral bioavailability of miconazole.
Review
Biology
Shamala Gopal Rajadurai, Mari Kannan Maharajan, Sajesh K. Veettil, Divya Gopinath
Summary: This study compared the effectiveness and safety of different antifungal agents for preventing oropharyngeal candidiasis in HIV-infected adults. The results showed that fluconazole was the most effective and safe antifungal agent for prophylaxis of OPC in HIV-infected adults.
Article
Chemistry, Medicinal
Hang Xu, Zhong-zuo Yan, Meng-bi Guo, Ran An, Xin Wang, Rui Zhang, Yan-hua Mou, Zhuang Hou, Chun Guo
Summary: By optimizing selenium-containing miconazole derivatives, compound B17 was discovered to have good antifungal activity against Candida albicans and showed promising in vivo efficacy after administration. This compound also exhibited significant effects on the treatment of resistant Candida albicans infections and could inhibit biofilm formation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Danish Khan, Aaron H. Nile, Ashutosh Tripathi, Vytas A. Bankaitis
Summary: The emergence of fungal superbugs resistant to current anti-fungal agents is diminishing our ability to treat infections effectively, highlighting the urgent need for new classes of anti-fungal drugs and targets. Recent evidence suggests that Sec14-like phosphatidylinositol transfer proteins (PITPs) could be unexplored portals for selectively disrupting phosphoinositide signaling in virulent fungi, offering exciting potential for next generation Sec14 inhibitors. Development of refined Sec14-directed inhibitors could enhance the chemical weaponry available for combating fungal pathogens and their interactions with human hosts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jie Tu, Na Liu, Yahui Huang, Wanzhen Yang, Chunquan Sheng
Summary: Candida auris is a major global threat to human health due to its strong drug resistance. This review provides a comprehensive overview of current strategies, drug candidates, and lead compounds for the treatment of C. auris. The resistance profiles and mechanisms are summarized, and the structures and activities of clinical candidates, drug combinations, antifungal chemosensitizers, repositioned drugs, new targets, and new types of compounds are discussed in detail. The review also offers perspectives for guiding future research in this field.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Otorhinolaryngology
Michael T. Brennan, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Yi Yang, Alexander Lin, Linda S. Elting, James S. Hodges, Rajesh V. Lalla
Summary: Demographic factors, insurance status, cancer type/location, and dental disease are associated with advanced head and neck cancer at diagnosis, suggesting potentially modifiable factors or factors to be considered in the screening process.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Editorial Material
Dentistry, Oral Surgery & Medicine
Alessandro Villa, Milda Chmieliauskaite, Lauren L. Patton
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2021)
Editorial Material
Dentistry, Oral Surgery & Medicine
Lauren L. Patton
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Editorial Material
Dentistry, Oral Surgery & Medicine
Lauren L. Patton
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jumana Karasneh, Janina Christoforou, Jennifer S. Walker, Pedro Diz Dios, Peter B. Lockhart, Lauren L. Patton
Summary: This study aims to determine bleeding control interventions (BCIs) that effectively control postoperative bleeding in patients with inherited functional platelet disorders (IFPDs) undergoing invasive dental procedures. The results of the study show that local measures and antifibrinolytics are effective, while platelet transfusion should be based on the patient's medical history and the clinician's judgment.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Oncology
Nathaniel S. Treister, Michael T. Brennan, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Rebecca Mitchell, Robert Haddad, Roy B. Tishler, Alexander Lin, Ryann Shadick, James S. Hodges, Rajesh Lalla
Summary: This report describes the incidence and clinical course of exposed bone in head and neck cancer patients treated with radiation therapy in the multicenter observational study OraRad. The results showed that the average maximum radiation dose to the affected area of exposed bone was 5456 cGy, with the majority of cases occurring in the mandible. The incidence of confirmed osteoradionecrosis was 3.1%, with risk factors including pre-RT extractions, higher radiation dose, and tobacco use.
Article
Oncology
Michael T. Brennan, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Alexander Lin, Linda S. Elting, James S. Hodges, Rajesh Lalla
Summary: This study aimed to investigate tooth failure in head and neck cancer patients after radiation therapy (RT). The results demonstrated that tooth failure occurred within 2 years after RT, and factors such as baseline tooth count, reduction in salivary flow rate, and noncompliance with oral hygiene were associated with a higher risk of tooth failure.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rajesh Lalla, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Erika S. Helgeson, Alexander Lin, Cynthia Rybczyk, Robert Dowsett, Upendra Hegde, Timothy S. Boyd, Thomas G. Duplinsky, Michael T. Brennan
Summary: This study aimed to examine the effects of radiation therapy for head and neck cancer on periodontal disease and its relationship to caries. The results showed that radiation therapy leads to gingival recession in the mandible, which may contribute to an increased risk of cervical caries in these patients.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Editorial Material
Dentistry, Oral Surgery & Medicine
Lauren L. Patton
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Oncology
Alexander Lin, Erika S. Helgeson, Nathaniel S. Treister, Brian L. Schmidt, Lauren L. Patton, Linda S. Elting, Rajesh Lalla, Michael T. Brennan, Thomas P. Sollecito
Summary: The OraRad study analyzed the impact of radiotherapy on salivary flow and patient-reported outcomes in a cohort of 572 patients receiving head and neck radiotherapy. The study found that the dose of radiotherapy was associated with changes in salivary flow and patient-reported outcomes. Salivary flow decreased to 37% of baseline at 6 months post-radiotherapy, but partially recovered to 59% at 18 months. Significant improvements in swallowing, mouth opening, dry mouth, and sticky saliva were observed between 6 and 18 months post-radiotherapy.
Editorial Material
Dentistry, Oral Surgery & Medicine
Lauren L. Patton
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
M. T. Brennan, N. S. Treister, T. P. Sollecito, B. L. Schmidt, L. L. Patton, A. Lin, L. S. Elting, E. S. Helgeson, R. V. Lalla
Summary: The prevalence of dental caries increases significantly after radiotherapy in HNC patients. Daily fluoride use, good oral hygiene practices, dental insurance, and higher education level are strongly associated with caries increment. Therefore, intensifying oral hygiene measures and improving accessibility to dental care can reduce the caries burden after radiotherapy in HNC patients.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Olivia Urquhart, Hillary R. DeLong, Kathleen M. Ziegler, Lauren Pilcher, Sarah Pahlke, Malavika P. Tampi, Kelly K. O'Brien, Lauren L. Patton, Nishant Agrawal, Theresa M. Hofstede, Deepak Kademani, Mark W. Lingen, Nathaniel S. Treister, Jillian Tsai, Alonso Carrasco-Labra, Ruth D. Lipman
Summary: This systematic review examines whether dental intervention is associated with a lower risk of osteoradionecrosis of the jaw (ORNJ) in patients with head and neck cancer. The results suggest that patients undergoing pre-RT extractions may have an increased risk of ORNJ. Limited evidence is available for other pre-RT procedures manipulating bone or tissue.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Rajesh Lalla, James S. Hodges, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Alexander Lin, Michael T. Brennan
Summary: This study identified tooth-level risk factors for tooth failure and exposed bone after radiation therapy for head and neck cancer. Untreated caries, periodontal pocket depth, recession, furcation score, and tooth mobility predicted tooth failure. Hopeless teeth not extracted and pocket depth predicted exposed bone occurrence.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Oncology
Lauren L. Patton, Erika S. Helgeson, Michael T. Brennan, Nathaniel S. Treister, Thomas P. Sollecito, Brian L. Schmidt, Alexander Lin, Bhishamjit S. Chera, Rajesh V. Lalla
Summary: This study evaluated the changes in oral health-related quality of life (OH-QOL) up to 2 years after radiation therapy (RT) for head and neck cancer (HNC) patients and identified the factors associated with these changes. The results showed that dry mouth, sticky saliva, and senses problems were the most persistently impacted OH-QOL variables at 24 months. Oropharyngeal tumor site, chemotherapy, ethnicity, age, and RT dose were found to have significant impacts on OH-QOL.
SUPPORTIVE CARE IN CANCER
(2023)
