Article
Microbiology
James S. Lewis, Nathan P. Wiederhold, Morgan Hakki, George R. Thompson
Summary: Isavuconazole is a newly available antifungal drug that is effective against various fungi. It is FDA-approved for the treatment of invasive aspergillosis and mucormycosis. Isavuconazole has significant advantages over other antifungal drugs, such as lack of QTc interval prolongation, more predictable pharmacokinetics, a simpler drug interaction profile, and improved tolerability.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Johan A. Maertens, Galia Rahav, Dong-Gun Lee, Alfredo Ponce-de-Leon, Isabel Cristina Ramirez Sanchez, Nikolay Klimko, Anne Sonet, Shariq Haider, Juan Diego Velez, Issam Raad, Liang-Piu Koh, Meinolf Karthaus, Jianying Zhou, Ronen Ben-Ami, Mary R. Motyl, Seongah Han, Anjana Grandhi, Hetty Waskin
Summary: Posaconazole was non-inferior to voriconazole in terms of all-cause mortality up to day 42 in patients with invasive aspergillosis. Posaconazole was well tolerated with fewer treatment-related adverse events compared to voriconazole in the study, supporting its use as a first-line treatment for the condition.
Article
Microbiology
Marjorie Vieira Batista, Maria Piedad Ussetti, Ying Jiang, Dionysios Neofytos, Anita Cassoli Cortez, Diego Feriani, Jayr Schmidt-Filho, Ivan Leonardo Avelino Franca-Silva, Issam Raad, Ray Hachem
Summary: This study compares the clinical outcomes and safety of Isavuconazole, Voriconazole, and an amphotericin B-based regimen in treating invasive fungal infections (IFIs) in immunocompromised patients with malignancies and transplants. Isavuconazole shows better safety profile compared to Voriconazole and amphotericin B. Factors such as age, obesity, renal insufficiency, and diabetes do not affect the response to antifungal therapy and overall outcome.
Article
Infectious Diseases
Didi Bury, Tom F. W. Wolfs, Rob ter Heine, Eline W. Muilwijk, Kim C. M. van der Elst, Wim J. E. Tissing, Roger J. M. Brueggemann
Summary: This study investigated the pharmacokinetics of isavuconazole in a pediatric cohort and found low bioavailability after nasogastric tube administration. The drug exposures were within the expected range following intravenous administration, and the pharmacokinetics of total and unbound isavuconazole were reported with a 5-fold range in the unbound fraction.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Teclegiorgis Gebremariam, Yiyou Gu, Shakti Singh, Therese Kitt, Ashraf S. Ibrahim
Summary: The combination therapy of L-AMB/isavuconazonium sulphate showed greater efficacy compared to monotherapy in immunosuppressed mice infected with the two most common causes of mucormycosis, indicating its potential as an optimal treatment strategy for human mucormycosis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Kelsey Jensen, Omar Abu Saleh, Supavit Chesdachai, Paul J. Jannetto, Kristin C. Mara, Zachary A. Yetmar, Christina G. Rivera
Summary: Drug level monitoring is important for evaluating dosing and effectiveness of posaconazole. High levels of posaconazole can lead to side effects. Monitoring should be done and dosage should be reduced when levels are high.
Article
Chemistry, Medicinal
Elham Ghobadi, Shahnaz Saednia, Saeed Emami
Summary: This review focuses on the synthetic approaches and structural diversity of triazolylbutanols derived from voriconazole, highlighting their importance in the design, synthesis, and development of novel antifungal drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Sara A. Scott, Cory Perry, Zahra Mahmoudjafari, Grace A. Martin, Samuel Boyd, Jeffrey Thompson, Beth Thomas
Summary: This retrospective study aimed to compare the prophylactic efficacy of different antifungal drugs in preventing invasive fungal infections. The results showed that there was a similar incidence of fungal infections in patients who received isavuconazole prophylaxis compared to those who received posaconazole or voriconazole prophylaxis during acute myeloid leukemia treatment or post-hematopoietic cell transplantation.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Microbiology
Jean Terrier, Marie-Celine Zanella, Stavroula Masouridi-Levrat, Ilona Kronig, Yves Chalandon, Nathalie Vernaz, Christian Van Delden, Genovefa Papanicolaou, Dionysios Neofytos
Summary: This study compared the plasma trough concentration levels of posaconazole and isavuconazole in high-risk allogeneic HCT recipients who received or did not receive letermovir. The results showed no significant difference in the levels between the two groups, indicating that letermovir coadministration did not have a significant effect.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Lan-hong Ruan, Ling-ling Fan, Kun Wang, Wan-qi Zhang, Xiao-jun Wang, Xiang-jun Qiu
Summary: A robust and reliable UPLC-MS/MS method was developed to detect the plasma concentration of erdafitinib in beagle dogs, and it was found that posaconazole and isavuconazole could increase the plasma exposure of erdafitinib in beagle dogs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Mycology
Zhimin Duan, Jianbo Tong, Nana Zheng, Rong Zeng, Yuzhen Liu, Min Li
Summary: This study evaluated the efficacy of combining the antiarrhythmic drug AMD with triazole drugs for Aspergillus spp. infection. The results showed that the combination of AMD with itraconazole or posaconazole had synergistic fungicidal effects on Aspergillus biofilms.
Article
Infectious Diseases
Rajeev Soman, Sourabh Chakraborty, Geethu Joe
Summary: The surge of COVID-19 associated Mucormycosis in India during the second wave of COVID-19 led to a scarcity of amphotericin B. However, the retrospective evaluation of 28 consecutive patients with Mucormycosis showed that posaconazole or isavuconazole could be used as alternative therapies with comparable outcomes and survival rates.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Qiqi Wang, Yun Li, Xuan Cai, Ruoyu Li, Bo Zheng, Ence Yang, Tianyu Liang, Xinyu Yang, Zhe Wan, Wei Liu
Summary: In this study, multidrug-resistant isolates of Candida glabrata exhibited resistance through different mechanisms. Overexpression of CDR1 and ERG11 in one isolate, and only overexpression of CDR1 in the other, may mediate resistance to POS. The S663P mutation in FKS2 and up-regulation of FKS2 in both isolates may contribute to echinocandin resistance.
Article
Immunology
Palash Samanta, Cornelius J. Clancy, Rachel Marini, Ryan M. Rivosecchi, Erin K. McCreary, Ryan K. Shields, Bonnie A. Falcione, Alex Viehman, Lauren Sacha, Eun Jeong Kwak, Fernanda P. Silveira, Pablo G. Sanchez, Matthew Morrell, Lloyd Clarke, M. Hong Nguyen
Summary: The study compared the effectiveness and tolerability of isavuconazole and voriconazole prophylaxis in lung transplant recipients. Isavuconazole was found to be effective in preventing invasive fungal infections and well tolerated.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Dermatology
Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Valliappan Muthu, Ashutosh Nath Aggarwal, Arunaloke Chakrabarti, Ritesh Agarwal
Summary: Oral itraconazole may be preferred over other azoles as initial therapy for CPA, while intravenous echinocandins and voriconazole may be preferred over amphotericin B in treating CPA. Randomised-controlled trials comparing different AFAs, especially newer AFAs, are urgently needed.
Review
Infectious Diseases
Corrado Girmenia, Alessandro Busca, Anna Candoni, Simone Cesaro, Mario Luppi, Anna Maria Nosari, Livio Pagano, Giuseppe Rossi, Adriano Venditti, Franco Aversa
Review
Hematology
Corrado Girmenia, Anna Candoni, Mario Delia, Roberto Latagliata, Alfredo Molteni, Esther N. Oliva, Giuseppe A. Palumbo, Antonella Poloni, Prassede Salutari, Valeria Santini, Maria Teresa Voso, Pellegrino Musto
Review
Hematology
Corrado Girmenia, Michele Cavo, Massimo Offidani, Francesco Scaglione, Alessandro Corso, Francesco Di Raimondo, Pellegrino Musto, Maria Teresa Petrucci, Giovanni Barosi
Review
Oncology
Marina Elena Cazzaniga, Romano Danesi, Corrado Girmenia, Pietro Invernizzi, Alessandra Elvevi, Massimo Uguccioni, Monica Perez Gila, Laura Amaducci, Francesco Atzori, Livio Blasi, Chiara Butti, Elena Collova, Enrico De Conciliis, Alessandra Fabi, Antonio Febbraro, Ornella Garrone, Lorenzo Gianni, Francesco Giotta, Nicla La Verde, Andrea Michelotti, Raffaella Palumbo, Ida Paris, Mirco Pistelli, Laura Pizzuti, Daniela Rubino, Maria Rosaria Valerio, Fable Zustovich
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Article
Infectious Diseases
Umberto Restelli, Davide Croce, Valeria Pacelli, Fabio Ciceri, Corrado Girmenia
INFECTION AND DRUG RESISTANCE
(2019)
Review
Surgery
Corrado Girmenia, Tiziana Lazzarotto, Francesca Bonifazi, Francesca Patriarca, Giuseppe Irrera, Fabio Ciceri, Franco Aversa, Franco Citterio, Umberto Cillo, Emanuele Cozzi, Enrico Gringeri, Fausto Baldanti, Rossana Cavallo, Pierangelo Clerici, Giovanni Barosi, Paolo Grossi
CLINICAL TRANSPLANTATION
(2019)
Review
Oncology
Pier Luigi Zinzani, Alessandro Rambaldi, Gianluca Gaidano, Corrado Girmenia, Monia Marchetti, Fabrizio Pane, Sante Tura, Giovanni Barosi
Article
Surgery
Irene Cassaniti, Anna A. Colombo, Paolo Bernasconi, Michele Malagola, Domenico Russo, Anna P. Iori, Corrado Girmenia, Raffaella Greco, Jacopo Peccatori, Fabio Ciceri, Francesca Bonifazi, Elena Percivalle, Giulia Campanini, Giulia Piccirilli, Tiziana Lazzarotto, Fausto Baldanti
Summary: This study highlights the importance of considering the clinical relevance of HCMV DNAemia during LMV prophylaxis in allo-HSCTRs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Infectious Diseases
Daniele Roberto Giacobbe, Eugenio Ciacco, Corrado Girmenia, Federico Pea, Gian Maria Rossolini, Giovanni Sotgiu, Carlo Tascini, Mario Tumbarello, Pierluigi Viale, Matteo Bassetti
INFECTION AND DRUG RESISTANCE
(2020)
Letter
Hematology
Juri Alessandro Giannotta, Bruno Fattizzo, Marta Bortolotti, Corrado Girmenia, Claudia Ielo, Elisabetta Metafuni, Adele Visentin, Vincenzo Apolito, Alessandro Lucchesi, Valentina Giai, Eloise Beggiato, Eros Di Bona, Fabio Giglio, Simona Sica, Anna Paola Iori, Wilma Barcellini
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Letter
Rheumatology
P. Meroni, D. Zavaglia, C. Girmenia
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2019)
Article
Oncology
Francesco Marchesi, Corrado Girmenia, Bianca Maria Goffredo, Emanuela Salvatorelli, Atelda Romano, Andrea Mengarelli, Giorgio Minotti, Pierantonio Menna
Meeting Abstract
Biophysics
Corrado Girmenia, Fabio Ciceri, Paolo Bernasconi, Alessandra Picardi, Maria Teresa Van Lint, Cristina De Pau, Stefano Guidi, Alessandro Busca, Angelo Michele Carella, Irene Cavattoni, Jacopo Peccatori, Daniela Cilloni, Giuseppe Console, Paolo Corradini, Francesco Onida, Anna Paola Iori, Giovanni Grillo, Anna Proia, Giuseppe Milone, Roberto Sorasio, Alessandra Crescimanno, Franco Narni, Francesca Patriarca, Francesco Zallio, Matteo Parma, Giovanni Pisapia, Stella Santarone, Rosanna Scime, Simona Sica, Paola Carluccio, Adriana Vacca, Daniele Vallisa, Arianna Masciulli, Chiara Pavoni, Sonia Mammoliti, Francesca Bonifazi, Alessandro Rambaldi
BONE MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Biophysics
Fabio Ciceri, Paolo Bernasconi, Alessandra Picardi, Anna Paola Iori, Maria Teresa Van Lint, Cristina De Pau, Stefano Guidi, Alessandro Busca, Angelo Michele Carella, Irene Cavattoni, Jacopo Peccatori, Fabio Giglio, Daniela Cilloni, Giuseppe Console, Paolo Corradini, Francesco Onida, Giovanni Grillo, Anna Proia, Giuseppe Milone, Roberto Sorasio, Alessandra Crescimanno, Franco Narni, Francesca Patriarca, Francesco Zallio, Matteo Parma, Giovanni Pisapia, Stella Santarone, Rosanna Scime, Simona Sica, Paola Carluccio, Adriana Vacca, Daniele Vallisa, Arianna Masciulli, Chiara Pavoni, Sonia Mammoliti, Corrado Girmenia, Francesca Bonifazi, Alessandro Rambaldi
BONE MARROW TRANSPLANTATION
(2018)
Review
Rheumatology
P. L. Meroni, D. Zavaglia, C. Girmenia
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2018)