In vitro activity of the new azole isavuconazole (BAL4815) compared with six other antifungal agents against 162 Cryptococcus neoformans isolates from Cuba

Cuban Cryptococcus isolates (n = 165) were tested in vitro against amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole, giving MIC90 values of 0.25, 89 49 0.25 0.1259 0.016, and 0.016 mu g/ml, respectively. Isavuconazole and posaconazole seem to be potentially active drugs for treating cryptococcal infections.