Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments

Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety

(2012) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

(2012) Satish Rao et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Randomized, Double-Blind, Placebo-Controlled Trial of Oral Docusate in the Management of Constipation in Hospice Patients

(2012) Yoko Tarumi et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Internal anal sphincter relaxation associated with bisacodyl-induced colonic high amplitude propagating contractions in children with constipation: a colo-anal reflex?

(2012) L. Rodriguez et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Laxanziengebrauch und Zufriedenheit chronisch obstipierter Frauen - eine Umfrage bei Patientinnen und Gastroenterologen in Deutschland

(2012) S. Müller-Lissner et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Randomised clinical trial: the ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation - a double-blind study

(2011) M. Simrén et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effects of A3309, an Ileal Bile Acid Transporter Inhibitor, on Colonic Transit and Symptoms in Females With Functional Constipation

(2011) Banny S Wong et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Randomized Placebo-Controlled Phase IIb Trial of A3309, A Bile Acid Transporter Inhibitor, for Chronic Idiopathic Constipation

(2011) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages

(2011) Nobutomo Ikarashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oral Bisacodyl Is Effective and Well-Tolerated in Patients With Chronic Constipation

(2011) Michael A. Kamm et al.   Clinical Gastroenterology and Hepatology

Long-Term Safety and Effectiveness of Lubiprostone, a Chloride Channel (ClC-2) Activator, in Patients with Chronic Idiopathic Constipation

(2011) Anthony J. Lembo et al.   DIGESTIVE DISEASES AND SCIENCES

Absence of Excretion of the Active Moiety of Bisacodyl and Sodium Picosulfate into Human Breast Milk: an Open-label Parallel-group, Multiple-dose Study in Healthy Lactating Women

(2011) Christian Friedrich et al.   Drug Metabolism and Pharmacokinetics

The pharmacokinetics, pharmacodynamics, clinical efficacy, safety and tolerability of linaclotide

(2011) Noel Lee et al.   Expert Opinion on Drug Metabolism & Toxicology

A case of cardiopulmonary arrest caused by laxatives-induced hypermagnesemia in a patient with anorexia nervosa and chronic renal failure

(2011) Hiroomi Tatsumi et al.   Journal of Anesthesia

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum magnesium concentration in children with functional constipation treated with magnesium oxide

(2011) Maiko Tatsuki   WORLD JOURNAL OF GASTROENTEROLOGY

The LUCK study: Laxative Usage in patients with GP-diagnosed Constipation in the UK, within the general population and in pregnancy. An epidemiological study using the General Practice Research Database (GPRD)

(2011) Anna C. E. Shafe et al.   Therapeutic Advances in Gastroenterology

The Carry-over Effect on the Bowel Habit in Elderly Long-term Patients of Long-term Bulk-forming Products Containing Stimulant Laxative

(2010) OSMO KINNUNEN et al.   ACTA MEDICA SCANDINAVICA

Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Sodium Picosulfate in Patients With Chronic Constipation

(2010) Stefan Mueller-Lissner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Efficacy of Linaclotide for Patients With Chronic Constipation

(2010) Anthony J. Lembo et al.   GASTROENTEROLOGY

5-HT4 receptor agonists: similar but not the same

(2010) J. H. De Maeyer et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A double-blind, placebo-controlled study of prucalopride in elderly patients with chronic constipation

(2010) S. Müller-lissner et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Efficacy and Safety of Lubiprostone in Patients with Chronic Constipation

(2009) Charles F. Barish et al.   DIGESTIVE DISEASES AND SCIENCES

A prospective randomized single blind trial of Fleet phosphate enema versus glycerin suppositories as preparation for flexible sigmoidoscopy

(2009) D. Underwood et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study

(2009) m. camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain

(2009) h. eutamene et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12-week, randomized, double-blind, placebo-controlled study

(2008) E. M. M. QUIGLEY et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

(2008) Jeffrey M Johnston et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

(2008) J Tack et al.   GUT

Extreme Hyperphosphatemia and Hypocalcemic Coma Associated with Phosphate Enema

(2008) Heng Jung Hsu et al.   INTERNAL MEDICINE

A Comparison of Sennosides-Based Bowel Protocols with and without Docusate in Hospitalized Patients with Cancer

(2008) Philippa Helen Hawley et al.   JOURNAL OF PALLIATIVE MEDICINE

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

(2008) Michael Camilleri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparative study on two colonic bowel preparations for patients with chronic constipation

(2008) Huimin Chen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Multicenter, 4-Week, Double-Blind, Randomized, Placebo-Controlled Trial of Lubiprostone, a Locally-Acting Type-2 Chloride Channel Activator, in Patients With Chronic Constipation

(2007) John F Johanson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY