Article
Gastroenterology & Hepatology
Ying Lian Xiao, Ning Dai, Shui Xiang He, De An Tian, Si De Liu, Zi Bin Tian, Xiao Yan Wang, Yan Qing Li, Xiao Hua Hou, Xiu Cai Fang, Zhi Li Wen, Wei Zheng Zeng, Hong Xu, Ming Jun Sun, Yu Lan Liu, Yong Dong Wu, Xi Zhong Shen, Xiao Wei Liu, De Liang Liu, Min Hu Chen
Summary: The study demonstrated the efficacy and safety of lubiprostone in treating Chinese adults with functional constipation, showing significant increase in the frequency of spontaneous bowel movements and improvement in stool consistency without causing severe adverse events.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Medicine, General & Internal
Jia-Hui Zhu, Yang-Yang Qian, Jun Pan, Chen He, Yu Lan, Wei-Na Chen, Bang-Mao Wang, Wei Zhao, Jing-Nan Li, Xiao-Qing Li, Bin Lv, Yi-Hong Fan, Xiu-Li Zuo, Zhen Li, Duo-Wu Zou, Zhao-Shen Li, Zhuan Liao
Summary: This study aimed to assess the efficacy and safety of the newly developed smartphone-controlled vibrating capsule (VC) in patients with functional constipation (FC). The results demonstrated that VC can promote defecation, ameliorate symptoms, and improve the quality of life in patients with FC with sustained efficacy.
Article
Nutrition & Dietetics
Sung-Ho Park, Eun Sil Lee, Sung Taek Park, Soo Young Jeong, Yeoul Yun, YongGyeong Kim, Yulah Jeong, Chang-Ho Kang, Hyun Jin Choi
Summary: Bacterial vaginosis (BV) is a common disease in women caused by abnormal microbiota growth in the vagina. This study evaluated the efficacy and safety of MED-01, a complex of five strains of probiotics, in improving vaginal health. The results showed that MED-01 significantly reduced the Nugent score and increased Lactobacillus plantarum while suppressing harmful bacteria after 12 weeks. No adverse events were observed. Therefore, MED-01 can be used as a probiotic for treating BV.
Article
Gastroenterology & Hepatology
Sunny Z. Hussain, Barrett Labrum, Shadreck Mareya, Stephen Stripling, Robert Clifford
Summary: The study assessed the safety and tolerability of oral lubiprostone in treating pediatric functional constipation, showing that it was well tolerated in children with no safety concerns observed.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Ole Frobert, Matthias Gotberg, David Erlinge, Zubair Akhtar, Evald H. Christiansen, Chandini R. MacIntyre, Keith G. Oldroyd, Zuzana Motovska, Andrejs Erglis, Rasmus Moer, Ota Hlinomaz, Lars Jakobsen, Thomas Engstrom, Lisette O. Jensen, Christian O. Fallesen, Svend E. Jensen, Oskar Angeras, Fredrik Calais, Amra Karegren, Jorg Lauermann, Arash Mokhtari, Johan Nilsson, Jonas Persson, Per Stalby, Abu K. M. M. Islam, Afzalur Rahman, Fazila Malik, Sohel Choudhury, Timothy Collier, Stuart J. Pocock, John Pernow
Summary: This study found that early influenza vaccination after myocardial infarction or in patients with high-risk coronary heart disease significantly reduced the risk of death, myocardial infarction, or stent thrombosis, and also decreased the risk of all-cause death and cardiovascular death within 12 months compared to placebo.
Article
Medicine, General & Internal
Fabiana Cristina Rosa Mitelmao, Cristiane de Cassia Bergamaschi, Marli Gerenutti, Karin Hachel, Marcus Tolentino Silva, Victor M. Balcao, Marta Maria Duarte Carvalho Vila
Summary: This study aims to evaluate the efficacy and safety of a combination of different strains of Lactobacillus sp. and Bifidobacterium sp. in functional constipation. The outcomes of interest include changes in frequency of weekly bowel movements, stool quality, volunteer withdrawal, adverse events, and serious adverse effects.
Article
Pharmacology & Pharmacy
Teng Ma, Ni Yang, Yong Xie, Yingmeng Li, Qiuping Xiao, Qiong Li, Hao Jin, Longjin Zheng, Zhihong Sun, Kexuan Zuo, Lai-Yu Kwok, Heping Zhang, Nonghua Lu, Wenjun Liu
Summary: Chronic constipation (CC) is a common gastrointestinal condition that impairs patients' quality of life. A large-scale trial was conducted to investigate the effect of probiotics (Lactiplantibacillus plantarum P9 [P9]) on CC. Ingesting P9 significantly improved bowel movements and reduced worries and concerns. The P9 group had an enriched population of beneficial bacteria and changes in the fecal metagenome and metabolome. These findings support the use of probiotics in managing CC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Xiaomei Zhang, Shanbin Chen, Ming Zhang, Fazheng Ren, Yimei Ren, Yixuan Li, Ning Liu, Yan Zhang, Qi Zhang, Ran Wang
Summary: This study investigated the effect of Lacticaseibacillus paracasei strain Shirota on constipation and depression symptoms in patients with specific etiology and gut microbiota. The results showed that LcS could alleviate certain symptoms of constipation and depression, regulate intestinal microbiota related to mental illness, and significantly decrease IL-6 levels.
Article
Biochemistry & Molecular Biology
Kaige Zhang, Hui Liu, Peng Liu, Qi Feng, Lihong Gan, Ling Yao, Gen Huang, Ziling Fang, Tingtao Chen, Nian Fang
Summary: This study shows that the administration of Lactiplantibacillus plantarum MH-301 can improve postoperative symptoms in patients with internal hemorrhoids. High-throughput sequencing analysis reveals that the group treated with L. plantarum MH-301 has a higher diversity of intestinal microbiota and a higher relative abundance of beneficial bacteria such as Bifidobacterium, Megamonas, and Lactobacillus. Therefore, L. plantarum MH-301 can enhance the efficacy of endoscopic sclerotherapy and improve bowel movements.
Article
Biochemistry & Molecular Biology
Luyao Wang, Linlin Wang, Peijun Tian, Botao Wang, Shumao Cui, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Wei Chen, Gang Wang
Summary: By using Bifidobacterium bifidum (B. bifidum) CCFM16 treatment, chronic constipation can be effectively relieved by regulating the gut microbiota and short-chain fatty acid metabolism.
Article
Clinical Neurology
Shifu Xiao, Piu Chan, Tao Wang, Zhen Hong, Shuzhen Wang, Weihong Kuang, Jincai He, Xiaoping Pan, Yuying Zhou, Yong Ji, Luning Wang, Yan Cheng, Ying Peng, Qinyong Ye, Xiaoping Wang, Yuncheng Wu, Qiumin Qu, Shengdi Chen, Shuhua Li, Wei Chen, Jun Xu, Dantao Peng, Zhongxin Zhao, Yansheng Li, Junjian Zhang, Yifeng Du, Weixian Chen, Dongsheng Fan, Yong Yan, Xiaowei Liu, Wei Zhang, Benyan Luo, Wenyuan Wu, Lu Shen, Chunfeng Liu, Peixian Mao, Qiumei Wang, Qianhua Zhao, Qihao Guo, Yongtao Zhou, Yi Li, Lijun Jiang, Wenwei Ren, Yingjun Ouyang, Yan Wang, Shuai Liu, Jianjun Jia, Nan Zhang, Zhonglin Liu, Raoli He, Tingyi Feng, Wenhui Lu, Huidong Tang, Ping Gao, Yingchun Zhang, Lanlan Chen, Lei Wang, You Yin, Qun Xu, Jinsong Xiao, Lin Cong, Xi Cheng, Hui Zhang, Dan Gao, Minghua Xia, Tenghong Lian, Guoping Peng, Xu Zhang, Bin Jiao, Hua Hu, Xueyan Chen, Yihui Guan, Ruixue Cui, Qiu Huang, Xianliang Xin, Hongjian Chen, Yu Ding, Jing Zhang, Teng Feng, Marc Cantillon, Kewei Chen, Jeffrey L. Cummings, Jian Ding, Meiyu Geng, Zhenxin Zhang
Summary: GV-971 demonstrated significant efficacy in improving cognition with sustained improvement across all observation periods of a 36-week trial. Treatment with GV-971 showed a significant advantage in cognitive function compared to placebo, and it was well-tolerated and safe.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Lei Qiao, Luo-Jia Wang, Yang Wang, Ying Chen, Hai-Lan Zhang, Shu-Cheng Zhang
Summary: XiaojiDaozhi Decoction, a Chinese Herbal Medicine prescription, has been shown to be a safe and effective method for the treatment of childhood constipation, improving bowel movements significantly without serious adverse effects.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Audrey M. Neyrinck, Julie Rodriguez, Bernard Taminiau, Florent Herpin, Patrice D. Cani, Georges Daube, Laure B. Bindels, Nathalie M. Delzenne
Summary: The study suggests that supplementation of rhubarb extract in middle-aged individuals promotes the growth of beneficial bacteria and short-chain fatty acids in the gut, leading to improved stool consistency and frequency, which contributes to relieving chronic constipation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Hui-Yeon Jang, Su-Jin Jung, Eun-Ock Park, Soo-Dong Kim, Je-Kyoung Kim, Soo-Wan Chae, Youn -Soo Cha, Seung-Ok Lee
Summary: The study found that beta-glucan derived from Schizophyllum commune (TBG-136) can increase the number of beneficial bacteria and improve symptoms of constipation.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Critical Care Medicine
Elisa Perger, Luigi Taranto Montemurro, Debora Rosa, Stefano Vicini, Mariapaola Marconi, Lucia Zanotti, Paolo Meriggi, Ali Azarbarzin, Scott A. Sands, Andrew Wellman, Carolina Lombardi, Gianfranco Parati
Summary: The combination therapy of Reb-Oxy significantly reduces the severity of OSA and improves vigilance. These findings highlight the potential of pharmacologic treatment for OSA.