标题
BACE1 as a Therapeutic Target in Alzheimer’s Disease: Rationale and Current Status
作者
关键词
Mild Cognitive Impairment, Amyloid Precursor Protein, Amyloid Cascade Hypothesis, BACE1 Inhibitor, Amyloid Precursor Protein Transgenic Mouse
出版物
DRUGS & AGING
Volume 30, Issue 10, Pages 755-764
出版商
Springer Nature
发表日期
2013-07-10
DOI
10.1007/s40266-013-0099-3
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels
- (2013) Carolyn C. Sachse et al. FASEB JOURNAL
- Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease
- (2013) B. F. Corbett et al. JOURNAL OF NEUROSCIENCE
- Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
- (2013) D. Fleck et al. JOURNAL OF NEUROSCIENCE
- Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
- (2013) Victor L Villemagne et al. LANCET NEUROLOGY
- Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein
- (2013) Jiang-Li Tan et al. PLoS One
- BACE1 Dependent Neuregulin Processing: Review
- (2012) Daniel Fleck et al. Current Alzheimer Research
- Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
- (2012) Peer-Hendrik Kuhn et al. EMBO JOURNAL
- β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment
- (2012) Jun Cai et al. EMBO Molecular Medicine
- Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease
- (2012) Fredrik Jeppsson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects
- (2012) Brian Hitt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Proteasein Vivo
- (2012) Lujia Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus
- (2012) Eugene L. Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid
- (2012) Matthew M. Weiss et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease
- (2012) Hongbing Huang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation
- (2012) Mihirbaran Mandal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors
- (2012) Michael A. Brodney et al. JOURNAL OF MEDICINAL CHEMISTRY
- Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
- (2012) Samuel W. Gerritz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Synthesis of β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β-Amyloid Peptides
- (2012) Britt-Marie Swahn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oligomeric Intermediates in Amyloid Formation: Structure Determination and Mechanisms of Toxicity
- (2012) Marcus Fändrich JOURNAL OF MOLECULAR BIOLOGY
- Interactome of the Amyloid Precursor Protein APP in Brain Reveals a Protein Network Involved in Synaptic Vesicle Turnover and a Close Association with Synaptotagmin-1
- (2012) Bernhard M. Kohli et al. JOURNAL OF PROTEOME RESEARCH
- BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease
- (2012) Linda Chami et al. Molecular Neurodegeneration
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population
- (2012) Mia Kero et al. NEUROBIOLOGY OF AGING
- BACE1 Inhibition Induces a Specific Cerebrospinal Fluid β-Amyloid Pattern That Identifies Drug Effects in the Central Nervous System
- (2012) Niklas Mattsson et al. PLoS One
- Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency
- (2011) Shawn J. Stachel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
- (2011) Viktorija Velanac et al. GLIA
- Inhibition of β-Secretasein Vivovia Antibody Binding to Unique Loops (D and F) of BACE1
- (2011) Lujia Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Developing β-secretase inhibitors for treatment of Alzheimer’s disease
- (2011) Arun K. Ghosh et al. JOURNAL OF NEUROCHEMISTRY
- Identification and biology of β-secretase
- (2011) Patty C. Kandalepas et al. JOURNAL OF NEUROCHEMISTRY
- Twenty years of Alzheimer’s disease-causing mutations
- (2011) Alison Goate et al. JOURNAL OF NEUROCHEMISTRY
- Robust Central Reduction of Amyloid- in Humans with an Orally Available, Non-Peptidic -Secretase Inhibitor
- (2011) P. C. May et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- BACE1 in central nervous system myelination revisited
- (2011) H Treiber et al. MOLECULAR PSYCHIATRY
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
- (2011) Lydia Alvarez-Erviti et al. NATURE BIOTECHNOLOGY
- Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors
- (2011) Graham M Pitcher et al. NATURE MEDICINE
- The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
- (2011) Eric Karran et al. NATURE REVIEWS DRUG DISCOVERY
- Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein
- (2011) Claudia Santosa et al. NEUROBIOLOGY OF DISEASE
- Amyloid-β Production: Major Link Between Oxidative Stress and BACE1
- (2011) Elena Tamagno et al. NEUROTOXICITY RESEARCH
- A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid- Production in Vivo
- (2011) J. K. Atwal et al. Science Translational Medicine
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
- (2011) Robert Vassar et al. Alzheimers Research & Therapy
- Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease
- (2010) James A. Duce et al. CELL
- β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
- (2010) Wan-Pin Chang et al. FASEB JOURNAL
- BACE: Therapeutic target and potential biomarker for Alzheimer's disease
- (2010) Geneviève Evin et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Ubiquitin Regulates GGA3-mediated Degradation of BACE1
- (2010) Eugene L. Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
- (2010) H. Fukumoto et al. JOURNAL OF NEUROSCIENCE
- BACE1 Deficiency Causes Altered Neuronal Activity and Neurodegeneration
- (2010) X. Hu et al. JOURNAL OF NEUROSCIENCE
- BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
- (2010) Brian D. Hitt et al. Molecular Neurodegeneration
- The secretases: enzymes with therapeutic potential in Alzheimer disease
- (2010) Bart De Strooper et al. Nature Reviews Neurology
- Disrupted-in-Schizophrenia-1 expression is regulated by -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade
- (2010) S. Seshadri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis
- (2009) Z. Wang et al. JOURNAL OF NEUROSCIENCE
- Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
- (2009) Matthew L. Hemming et al. PLoS One
- Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons
- (2009) L. Wen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a small molecule β-secretase inhibitor that binds without catalytic aspartate engagement
- (2008) Thomas G. Steele et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Decrease in age-adjusted cerebrospinal fluid β-secretase activity in Alzheimer's subjects
- (2008) Guoxin Wu et al. CLINICAL BIOCHEMISTRY
- BACE1 Structure and Function in Health and Alzheimers Disease
- (2008) Sarah Cole et al. Current Alzheimer Research
- BACE1 Knock-Outs Display Deficits in Activity-Dependent Potentiation of Synaptic Transmission at Mossy Fiber to CA3 Synapses in the Hippocampus
- (2008) H. Wang et al. JOURNAL OF NEUROSCIENCE
- Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
- (2008) Mohammad Ali Faghihi et al. NATURE MEDICINE
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
- (2008) Lin Mei et al. NATURE REVIEWS NEUROSCIENCE
- Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
- (2008) Tracy O'Connor et al. NEURON
- Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression
- (2008) S. S. Hebert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice
- (2008) A. V. Savonenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
- (2008) Matthew L Hemming et al. PLOS BIOLOGY
- Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease
- (2007) Peter J. Crouch et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started