Inhibition of β-Secretasein Vivovia Antibody Binding to Unique Loops (D and F) of BACE1

Strategy for effective brain drug delivery

(2010) M. Intakhab Alam et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A  Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

(2010) H. Fukumoto et al.   JOURNAL OF NEUROSCIENCE

Synaptic NMDA Receptor Activation Stimulates  -Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-  Production

(2009) S. E. Hoey et al.   JOURNAL OF NEUROSCIENCE

Getting into the Brain

(2008) Mayur M Patel et al.   CNS DRUGS

P-Glycoprotein Efflux and Other Factors Limit Brain Amyloid   Reduction by  -Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitors in Mice

(2008) J. E. Meredith et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

(2008) Romano Silvestri   MEDICINAL RESEARCH REVIEWS

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE