Mouse models of intestinal cancer

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy

(2015) Sander Kelderman et al.   CANCER CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

E-cadherin can limit the transforming properties of activating  -catenin mutations

(2015) D. J. Huels et al.   EMBO JOURNAL

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis

(2014) Anne E. Powell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

(2014) Nicola Valeri et al.   CANCER CELL

The utility ofApc-mutant rats in modeling human colon cancer

(2014) Amy A. Irving et al.   Disease Models & Mechanisms

Temozolomide Increases the Number of Mismatch Repair–Deficient Intestinal Crypts and Accelerates Tumorigenesis in a Mouse Model of Lynch Syndrome

(2014) Kamila Wojciechowicz et al.   GASTROENTEROLOGY

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

(2014) William J. Faller et al.   NATURE

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice

(2014) Lukas E. Dow et al.   PLoS One

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

(2014) Maia Chanrion et al.   Nature Communications

Sox9 Induction, Ectopic Paneth Cells, and Mitotic Spindle Axis Defects in Mouse Colon Adenomatous Epithelium Arising From Conditional Biallelic Apc Inactivation

(2013) Ying Feng et al.   AMERICAN JOURNAL OF PATHOLOGY

EMT is the dominant program in human colon cancer

(2013) Andre Loboda et al.   BMC Medical Genomics

A Genetic Progression Model of BrafV600E-Induced Intestinal Tumorigenesis Reveals Targets for Therapeutic Intervention

(2013) Roland Rad et al.   CANCER CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

(2013) Kevin B. Myant et al.   Cell Stem Cell

The Gastrointestinal Tumor Microenvironment

(2013) Michael Quante et al.   GASTROENTEROLOGY

Pathology of Rodent Models of Intestinal Cancer: Progress Report and Recommendations

(2013) Mary Kay Washington et al.   GASTROENTEROLOGY

PTENloss andKRASactivation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine

(2013) Emma J Davies et al.   JOURNAL OF PATHOLOGY

What are the best routes to effectively model human colorectal cancer?

(2013) Madeleine Young et al.   Molecular Oncology

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

PIK3CA and APC mutations are synergistic in the development of intestinal cancers

(2013) D A Deming et al.   ONCOGENE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel

(2012) Douglas K Rex et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors

(2012) Sarah Schwitalla et al.   CANCER CELL

Mice Expressing Activated PI3K Rapidly Develop Advanced Colon Cancer

(2012) A. A. Leystra et al.   CANCER RESEARCH

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice

(2012) Yinghui Li et al.   CARCINOGENESIS

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

A Porcine Model of Familial Adenomatous Polyposis

(2012) Tatiana Flisikowska et al.   GASTROENTEROLOGY

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system

(2012) T Jardé et al.   ONCOGENE

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

Controlled gene expression in primary Lgr5 organoid cultures

(2011) Bon-Kyoung Koo et al.   NATURE METHODS

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

(2010) Moritz Bennecke et al.   CANCER CELL

Cyclin D2-Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss

(2010) A. M. Cole et al.   CANCER RESEARCH

A new conditional Apc-mutant mouse model for colorectal cancer

(2010) E. C. Robanus-Maandag et al.   CARCINOGENESIS

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

The Chromosomal Instability Pathway in Colon Cancer

(2010) Maria S. Pino et al.   GASTROENTEROLOGY

Severe polyposis in Apc1322Tmice is associated with submaximal Wnt signalling and increased expression of the stem cell markerLgr5

(2010) Annabelle Lewis et al.   GUT

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine

(2010) D Athineos et al.   ONCOGENE

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

(2010) K. E. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The Apc1322T Mouse Develops Severe Polyposis Associated With Submaximal Nuclear β-Catenin Expression

(2009) Patrick Pollard et al.   GASTROENTEROLOGY

TGF-β Receptor Inactivation and Mutant Kras Induce Intestinal Neoplasms in Mice via a β-Catenin-Independent Pathway

(2009) Patty Trobridge et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Complete deletion of Apc results in severe polyposis in mice

(2009) A F Cheung et al.   ONCOGENE

The Fbxw7/hCdc4 tumor suppressor in human cancer

(2008) YingMeei Tan et al.   CANCER LETTERS

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

(2008) Liqin Zhu et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

An ENU-induced mutant archive for gene targeting in rats

(2008) Tomoji Mashimo et al.   NATURE GENETICS

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

(2008) Victoria Marsh et al.   NATURE GENETICS

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS

Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene

(2008) Aytekin Akyol et al.   NATURE METHODS

Apc mice: Models, modifiers and mutants

(2008) Amy E. McCart et al.   PATHOLOGY RESEARCH AND PRACTICE