Article
Oncology
Shibnath Ghatak, Vincent C. C. Hascall, Nikos Karamanos, Roger R. R. Markwald, Suniti Misra
Summary: Cancer-initiating cells drive colorectal tumor growth by interacting with supportive niches in the microenvironment. In this study, researchers investigated the interplay between cancer-initiating cells and the chemotherapeutic drug FOLFOX, as well as the role of cancer-associated fibroblasts (CAFs) in this process. They found that CAFs secreted factors that enhanced the expression of a specific immunophenotype in cancer-initiating cells, promoting drug resistance. Blocking the interaction between cancer-initiating cells and CAF-derived factors significantly reduced the tumorigenic potential of colorectal tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Analytical
Chae Hwan Cho, Ji Hong Kim, Jayoung Kim, Jong Won Yun, Tae Jung Park, Jong Pil Park
Summary: An advanced electrochemical biosensor based on affinity peptides was developed to discriminate the progression from colorectal adenoma to carcinoma, showing improved binding abilities and stability.
ANALYTICA CHIMICA ACTA
(2021)
Review
Oncology
Kristen K. Ciombor, John H. Strickler, Tanios S. Bekaii-Saab, Rona Yaeger
Summary: BRAF-mutated advanced colorectal cancer is a critical subset with prognostic and predictive implications. Standard therapies include bevacizumab and encorafenib, but resistance to targeted treatment remains a challenge.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Manita Shakya, Surbhi, Anne White, C. Bruce Verchere, Malcolm J. Low, Iris Lindberg
Summary: POMC neurons play a crucial role in regulating food intake and energy expenditure, while defects in POMC synthesis, processing, and receptor signaling can lead to obesity. Studies show that PC1/3 deficiency is strongly associated with obesity risk, but alterations in POMC processing may not be the sole cause of obesity in PCSK1 deficiency.
Article
Endocrinology & Metabolism
Manita Shakya, Surbhi, Anne White, C. Bruce Verchere, Malcolm J. Low, Iris Lindberg
Summary: Pro-opiomelanocortin (POMC) neurons play a crucial role in regulating food intake and energy expenditure, and defects in POMC synthesis, processing, and receptor signaling have been linked to obesity. However, research on the impact of PC1/3-mediated POMC processing on body weight regulation is still inconclusive.
Article
Gastroenterology & Hepatology
Sudiksha Rathan-Kumar, Joseph T. Roland, Michael Momoh, Anna Goldstein, Lynne A. Lapierre, Elizabeth Manning, Louise Mitchell, Jim Norman, Izumi Kaji, James R. Goldenring
Summary: This study demonstrates the importance of Rab11FIP1 in maintaining mucosal integrity in the colon. Deficiency of Rab11FIP1 leads to mistrafficking of Rab14 and MUC13, as well as a decrease in colonic goblet cells, resulting in impaired mucosal integrity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ya Zhou, Li Mu, Xiao-Lu Liu, Qin Li, Li-Xuan Ding, Hong-Chuan Chen, Ying Hu, Fu-Shu Li, Wen-Juan Sun, Bai-Cheng He, Ke Wu
Summary: The study found that Tetrandrine can inhibit the proliferation of colon cancer cells SW620 and induce apoptosis by up-regulating BMP9 and down-regulating Akt1/2/3 and PTEN to exert anticancer effects.
Article
Oncology
Qiao Qiao, Ruixia Bai, Wanying Song, Haining Gao, Minyu Zhang, Jingkun Lu, Mei Hong, Xuan Zhang, Peng Sun, Qian Zhang, Pengwei Zhao
Summary: DEFA5 expression is decreased in colon cancer, and its overexpression inhibits proliferation and metastasis of colon cancer cells, suggesting a potential tumor suppressor role.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jeetendra Kumar Nag, Priyanga Appasamy, Shoshana Sedley, Hodaya Malka, Tatyana Rudina, Rachel Bar-Shavit
Summary: RNF43, a cell-surface transmembrane E3 ubiquitin ligase, negatively regulates PAR(2) by promoting its membrane elimination and degradation, affecting colon cancer growth. R-spondin2 and LGR5 can rescue PAR(2) degradation. PAR(2) is an important oncogene for the growth and development of colon cancer.
Article
Oncology
Peter Savas, Louisa L. Lo, Stephen J. Luen, Elizabeth F. Blackley, Jason Callahan, Kate Moodie, Courtney T. van Geelen, Yi-An Ko, Chen -Fang Weng, Lironne Wein, Maria Joao Silva, Andjelija Zivanovic Bujak, Miriam M. Yeung, Sarah Ftouni, Rodney J. Hicks, Prudence A. Francis, Chee Khoon Lee, Sarah -Jane Dawson, Sherene Loi
Summary: Alpelisib monotherapy demonstrated efficacy in heavily pretreated ER + breast cancer, and the dynamics of PIK3CA mutation and ESR1 mutation detected in plasma can serve as candidate biomarkers for predicting treatment response.
Article
Agriculture, Multidisciplinary
Li Yan, Yufan Jin, Junping Pan, Xiang He, Shiqian Zhong, Rongcai Zhang, LokLam Choi, Weiwei Su, Jiaxu Chen
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by memory and cognition impairment. A compound called 7,8-DHC derived from coumarin has been found to reduce beta-amyloid accumulation and improve learning and memory impairment by activating specific signaling pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Chaozheng Zhang, Yuening Cao, Yi Zuo, Hongbin Cheng, Changqun Liu, Xila Xia, Bo Ren, Yun Deng, Maolin Wang, Jun Lu
Summary: Bruceine A (BA), derived from Bruceine javanica, displays multiple biological activities and regulates various intracellular signal transduction pathways. However, its pharmacological mechanism in treating colon cancer (CC) remains unclear. In this study, BA was found to exhibit anticancer effects on CC cells by targeting the Akt1 and Jun as well as the PI3K/Akt pathway. Additionally, BA inhibited cell cycle progression, promoted apoptosis, and suppressed cell migration in CC cells. These findings suggest that BA has the potential to be a promising chemotherapy drug for the treatment of CC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Chia-Hsun Hsieh, Chau-Ting Yeh, Ya-Hui Huang, Ming-Wei Lai
Summary: This study evaluated the feasibility of drug sensitivity tests for circulating tumor cells (CTCs) isolated from patients with advanced hepatocellular carcinoma (HCC). The results showed that CTC count increased after chemotherapy but rarely developed drug resistance in patients receiving sorafenib. Therefore, CTC drug sensitivity tests may help predict treatment response for patients with advanced HCC.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Julia L. Drewes, Jie Chen, Nicholas O. Markham, Reece J. Knippel, Jada C. Domingue, Ada J. Tam, June L. Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M. Dejea, Sarah Tomkovich, John Michel, James R. White, Fuad Mohammad, Victoria L. Campodonico, Cody N. Heiser, Xinqun Wu, Shaoguang Wu, Hua Ding, Patricia Simner, Karen Carroll, Martha J. Shrubsole, Robert A. Anders, Seth T. Walk, Christian Jobin, Fengyi Wan, Robert J. Coffey, Franck Housseau, Ken S. Lau, Cynthia L. Sears
Summary: This study reveals the role of toxigenic Clostridioides difficile in promoting colorectal cancer, suggesting that chronic colonization with this pathogenic bacteria may drive tumor development through the induction of Wnt signaling, reactive oxygen species, and protumorigenic mucosal immune responses.
Article
Multidisciplinary Sciences
Abdullah An Naser, Takehiro Miyazaki, Jun Wang, Shuji Takabayashi, Theeranukul Pachoensuk, Toshinobu Tokumoto
Summary: The formation of testicular teratomas in mice may be related to mutations in the Dnd1 gene, but it is not the sole factor, as other genes may be involved. Experimental studies have shown that testicular teratomas can be induced by transplanting fetal testes into adult testes.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Christopher D. Zahm, Viswa Teja Colluru, Douglas G. McNeel
PHARMACOLOGY & THERAPEUTICS
(2017)
Article
Oncology
Christopher D. Zahm, Viswa T. Colluru, Douglas G. McNeel
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Oncology
Christopher D. Zahm, Viswa T. Colluru, Sean J. McIlwain, Irene M. Ong, Douglas G. McNeel
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Oncology
Matthew Scarpelli, Christopher Zahm, Scott Perlman, Douglas G. McNeel, Robert Jeraj, Glenn Liu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Review
Oncology
Melissa Gamat-Huber, Donghwan Jeon, Laura E. Johnson, Jena E. Moseman, Anusha Muralidhar, Hemanth K. Potluri, Ichwaku Rastogi, Ellen Wargowski, Christopher D. Zahm, Douglas G. McNeel
Article
Oncology
Alyssa A. Leystra, Brock J. Gilsdorf, Amanda M. Wisinger, Elise R. Warda, Shanna Wiegand, Christopher D. Zahm, Kristina A. Matkowskyj, Dustin A. Deming, Naghma Khan, Quincy Rosemarie, Chelsie K. Sievers, Alexander R. Schwartz, Dawn M. Albrecht, Linda Clipson, Hasan Mukhtar, Michael A. Newton, Richard B. Halberg
Summary: The study found that intestinal tumors with a multi-ancestral architecture involving at least two distinct clones exhibited increased growth and invasiveness, along with an impact on the response to low-dose aspirin. Genetically distinct tumor-founding cells can contribute to early intratumoral heterogeneity, enhancing colon tumor progression and affecting the response to aspirin.
Article
Oncology
Christopher D. Zahm, Jena E. Moseman, Lauren E. Delmastro, Douglas G. Mcneel
Summary: The study demonstrates that combining PD-1 and LAG-3 checkpoint blockade can further enhance the efficacy of anti-tumor vaccination, particularly showing the greatest effect in specific tumor models. This suggests that anti-tumor vaccination may be most effective when combined with concurrent blockade of both PD-1 and LAG-3, as well as potentially other checkpoint receptors whose expression is increased on CD8 + T cells following vaccine-mediated activation.
Meeting Abstract
Oncology
Hemanth Kumar Potluri, Reinier Hernandez, Christopher D. Zahm, Joseph Grudzinski, Christopher Massey, Jamey Weichert, Douglas G. McNeel
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
Reinier Hernandez, Hemanth Potluri, Eduardo Aluicio-Sarduy, Joseph Grudzinski, Christopher Massey, Christopher Zahm, Jonathan Engle, Douglas McNeel, Jamey Weichert
JOURNAL OF NUCLEAR MEDICINE
(2020)
Meeting Abstract
Oncology
Hemanth Potluri, Reinier Hernandez, Christopher Zahm, Joseph Grudzinski, Christopher Massey, Jamey Weichert, Douglas McNeel
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Meeting Abstract
Oncology
Christopher Zahm, Douglas McNeel, Laurne Delmastro
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Meeting Abstract
Oncology
Donghwan Jeon, Christopher Zahm, Douglas McNeel
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
R. Hernandez, C. Zahm, E. Aluicio-Sarduy, H. Potluri, J. Grudzinski, C. Massey, A. Bitton, J. Engle, D. McNeel, J. Weichert
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Biology
Reinier Hernandez, Kirsti L. Walker, Joseph J. Grudzinski, Eduardo Aluicio-Sarduy, Ravi Patel, Christopher D. Zahm, Anatoly N. Pinchuk, Christopher F. Massey, Ariana N. Bitton, Ryan J. Brown, Paul M. Sondel, Zachary S. Morris, Jonathan W. Engle, Christian M. Capitini, Jamey P. Weichert
COMMUNICATIONS BIOLOGY
(2019)
Article
Oncology
Emily B. Ehlerding, Hye Jin Lee, Dawei Jiang, Carolina A. Ferreira, Christopher D. Zahm, Peng Huang, Jonathan W. Engle, Douglas G. McNeel, Weibo Cai
AMERICAN JOURNAL OF CANCER RESEARCH
(2019)