Article
Chemistry, Physical
Jianhai Chen, Jianwei Tan, Jian Li, Wenxiang Cheng, Liqing Ke, Anqiao Wang, Qiqing Wang, Sien Lin, Gang Li, Benguo Wang, Jingqin Chen, Peng Zhang
Summary: This study presents a genetically engineered biomimetic membrane-coated mRNA (MR@P-mPTEN) carrier that effectively delivers mRNA-PTEN directly to the rheumatoid arthritis (RA) joint. The carrier is prepared by overexpressing tumor necrosis factor (TNF-α) receptors on macrophage biomimetic membranes, which serve as decoys to reduce inflammatory pathway activation. The results show that MR@P-mPTEN exhibits good stability, RA targeting, and competitive binding with TNF-α, activating the PTEN pathway to inhibit synovitis and joint damage.
Article
Chemistry, Multidisciplinary
Xiaoqing Han, Luopeng Bi, Yunyun Wu, Jiao Yan, Xiaqing Wu, Runxiao Zheng, Yingying Sun, Hua Zhang, Zhenxin Wang, Yanbo Wang, Haiyuan Zhang
Summary: This study presents a promising anti-metastasis strategy by using functional exosomes ((G)Exo(I)) to specifically target the lungs and block the recruitment of granulocytic myeloid-derived suppressor cells (G-MDSCs). This strategy effectively transforms the lung microenvironment from immunosuppressive to immunostimulatory, leading to the inhibition of postoperative lung metastasis of melanoma.
Article
Oncology
Abigail L. Miller, Naiara Perurena, Alycia Gardner, Toshinori Hinoue, Patrick Loi, Peter W. Laird, Karen Cichowski
Summary: DAB2IP is a tumor suppressor that is mutated or silenced in colorectal cancers with KRAS or BRAF mutations. Its loss promotes tumor development by activating RAS proteins and triggering inflammatory mediators and protumorigenic macrophage recruitment.
Article
Oncology
Koichi Tomoshige, William D. Stuart, Iris M. Fink-Baldauf, Masaoki Ito, Tomoshi Tsuchiya, Takeshi Nagayasu, Tomoki Yamatsuji, Morihito Okada, Takuya Fukazawa, Minzhe Guo, Yutaka Maeda
Summary: The transcription factor FOXA2 has different effects on lung tumorigenesis depending on the oncogenes present. It inhibits tumor development driven by EGFRL858R but promotes tumor growth driven by KRASG12D. Additionally, FOXA2 induces the expression of MUC5AC, leading to the development of invasive mucinous adenocarcinoma (IMA), a subtype of lung cancer.
Article
Oncology
Qi Yao, Lanzhen He, Xucan Gao, Na Tang, Lifen Lin, Xiaofang Yu, Dong Wang
Summary: The study revealed that METTL14 is significantly downregulated in STAD and inhibits tumor growth and metastasis by stabilizing PTEN mRNA expression. METTL14 may serve as a potential prognostic and therapeutic target for STAD.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jason Tasoulas, Sonal Srivastava, Xiaonan Xu, Valentina Tarasova, Anastasios Maniakas, Florian A. Karreth, Antonio L. Amelio
Summary: The head and neck region is highly susceptible to cancer, with over 1.5 million new cases reported worldwide in 2020. Significant progress has been made in understanding the disease mechanisms and tailoring treatments to individual tumor characteristics using genetically engineered mouse models. These models have successfully replicated various aspects of head and neck cancers.
Article
Gastroenterology & Hepatology
Nina Pfisterer, Christoph Ammer-Herrmenau, Kai Antweiler, Stefan Kueffer, Volker Ellenrieder, Albrecht Neesse
Summary: The study found similarities in the microbial composition of tumor microbiomes between pancreatic ductal adenocarcinoma (PDAC) mice and human PDAC patients. KPC tumors harbored significantly more bacterial components compared to healthy pancreas tissue.
Article
Medicine, General & Internal
Shin Enosawa, Huai-Che Hsu, Yusuke Yanagi, Hitomi Matsunari, Ayuko Uchikura, Hiroshi Nagashima
Summary: To develop novel medical technologies, a genetically engineered ornithine transcarbamylase-deficient (OTCD) pig strain was established and its characteristics and treatment responsiveness were reported. The OTCD pigs were obtained through mating an OTCD carrier female with a wild-type male, with the disease phenotype only appearing in males due to X-linked recessive inheritance. Treatment with nitrogen-scavenging agents based on a clinical protocol significantly extended the survival time of the OTCD pigs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Shujun Zhang, Peilong Li, Juan Li, Jie Gao, Qiuchen Qi, Guoying Dong, Xiaoyan Liu, Qinlian Jiao, Yunshan Wang, Lutao Du, Hanxiang Zhan, Shuo Xu, Chuanxin Wang
Summary: This study identified key transcription factors (TFs) through multiomics sequencing in pancreatic ductal adenocarcinoma (PDAC) and investigated their molecular mechanisms. FOSL2 was identified as a critical regulator that was up-regulated in PDAC and associated with poor prognosis, promoting cell proliferation, migration, and invasion. The study also revealed an immunosuppressive regulatory axis involving KRAS/MAPK-FOSL2-CCL28 in PDAC development.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Tiago Bordeira Gaspar, Jose Manuel Lopes, Paula Soares, Joao Vinagre
Summary: This article reviews the latest research progress on mouse models of pancreatic neuroendocrine neoplasms (PanNENs) and their correlation with human tumors. The article includes models with genetic alterations in Men1 and glucagon receptor genes, as well as unique models of early-onset, highly vascularized, invasive carcinomas. It also discusses the most recent models evaluating pathways related to cell cycle and apoptosis, Pi3k/Akt/mTOR, and Atrx/Daxx. The article provides researchers with a guide summarizing the main clinical features and highlights the challenges to overcome for future models to better replicate human disease.
ENDOCRINE-RELATED CANCER
(2022)
Review
Oncology
Kajal Biswas, Altaf Mohammed, Shyam K. Sharan, Robert H. Shoemaker
Summary: Advances in molecular diagnostics have improved the diagnosis and understanding of hereditary cancers. Preclinical experimental models, such as genetically engineered mouse (GEM) models, play a crucial role in studying and preventing cancer in high-risk populations.
Article
Oncology
Catherine Lee, Ziyue Karen Jiang, Simon Planken, Lisa K. Manzuk, Roberto Ortiz, Michael Hall, Kavon Noorbehesht, Sripad Ram, Timothy Affolter, Gabriel E. Troche, Nathan T. Ihle, Theodore Johnson, Youngwook Ahn, Manfred Kraus, Anand Giddabasappa
Summary: KRAS is a frequently mutated oncogene in lung, colorectal, and pancreatic cancers. Clinical trials targeting KRAS G12C have shown promising results in NSCLC, but resistance to treatment is a concern. More research is needed to understand resistance mechanisms and improve patient responses.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Oncology
Martin F. Berthelsen, Siv L. Leknes, Maria Riedel, Mette A. Pedersen, Justin V. Joseph, Henrik Hager, Mikkel H. Vendelbo, Martin K. Thomsen
Summary: This study using a mouse model of lung cancer showed that loss of Stk11 is a key driver for adenocarcinoma progression, while loss of Pten is dispensable for adenocarcinoma development.
Review
Oncology
Ryo Shiraishi, Daisuke Kawauchi
Summary: Recent studies have classified medulloblastoma into four molecular subgroups, each with distinct oncogenic drivers and cellular origins. Understanding the molecular signals driving tumorigenesis is still lacking, necessitating further research into the etiology of tumors to establish effective treatment strategies.
Article
Oncology
Karen R. Reed, Igor V. Korobko, Natalia Ninkina, Elena V. Korobko, Ben R. Hopkins, James L. Platt, Vladimir Buchman, Alan R. Clarke
Article
Biochemistry & Molecular Biology
David J. Huels, Rachel A. Ridgway, Sorina Radulescu, Marc Leushacke, Andrew D. Campbell, Sujata Biswas, Simon Leedham, Stefano Serra, Runjan Chetty, Guenievre Moreaux, Lee Parry, James Matthews, Fei Song, Ann Hedley, Gabriela Kalna, Fatih Ceteci, Karen R. Reed, Valerie S. Meniel, Aoife Maguire, Brendan Doyle, Ola Soderberg, Nick Barker, Alastair Watson, Lionel Larue, Alan R. Clarke, Owen J. Sansom
Article
Oncology
Naveen K. Tangudu, Vinod K. Verma, Tristan D. Clemons, Syed S. Beevi, Trevor Hay, Ganesh Mahidhara, Meera Raja, Rekha A. Nair, Liza E. Alexander, Anant B. Patel, Jedy Jose, Nicole M. Smith, Bogdan Zdyrko, Anne Bourdoncle, Igor Luzinov, K. Swaminathan Iyer, Alan R. Clarke, Lekha Dinesh Kumar
MOLECULAR CANCER THERAPEUTICS
(2015)
Article
Cell Biology
Wei-Yu Lu, Thomas G. Bird, Luke Boulter, Atsunori Tsuchiya, Alicia M. Cole, Trevor Hay, Rachel V. Guest, Davina Wojtacha, Tak Yung Man, Alison Mackinnon, Rachel A. Ridgway, Timothy Kendall, Michael J. Williams, Thomas Jamieson, Alex Raven, David C. Hay, John P. Iredale, Alan R. Clarke, Owen J. Sansom, Stuart J. Forbes
NATURE CELL BIOLOGY
(2015)
Article
Pathology
Victoria Marsh Durban, Marnix Jansen, Emma J. Davies, Folkert H. Morsink, G. Johan A. Offerhaus, Alan R. Clarke
AMERICAN JOURNAL OF PATHOLOGY
(2014)
Article
Biochemical Research Methods
Rimpi Khurana, Vinod Kumar Verma, Abdul Rawoof, Shrish Tiwari, Rekha A. Nair, Ganesh Mahidhara, Mohammed M. Idris, Alan R. Clarke, Lekha Dinesh Kumar
BMC BIOINFORMATICS
(2014)
Article
Oncology
Victoria Marsh, Emma J. Davies, Geraint T. Williams, Alan R. Clarke
JOURNAL OF PATHOLOGY
(2013)
Review
Oncology
Madeleine Young, Liliana Ordonez, Alan R. Clarke
MOLECULAR ONCOLOGY
(2013)
Article
Biochemistry & Molecular Biology
T. Jarde, R. J. Evans, K. L. McQuillan, L. Parry, G. J. Feng, B. Alvares, A. R. Clarke, T. C. Dale
Article
Biochemistry & Molecular Biology
K. R. Greenow, A. R. Clarke, G. T. Williams, R. Jones
Article
Biochemistry & Molecular Biology
V. Meniel, M. Megges, M. A. Young, A. Cole, O. J. Sansom, A. R. Clarke
Article
Multidisciplinary Sciences
Dong-In Koh, Dohyun Han, Hoon Ryu, Won-Il Choi, Bu-Nam Jeon, Min-Kyeong Kim, Youngsoo Kim, Jin Young Kim, Lee Parry, Alan R. Clarke, Albert B. Reynolds, Man-Wook Hur
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Cell & Tissue Engineering
Aliaksei Z. Holik, Joanna Krzystyniak, Madeleine Young, Kirsty Richardson, Thierry Jarde, Pierre Chambon, Boris Y. Shorning, Alan R. Clarke
Article
Genetics & Heredity
Aliaksei Z. Holik, Madeleine Young, Joanna Krzystyniak, Geraint T. Williams, Daniel Metzger, Boris Y. Shorning, Alan R. Clarke