Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2

(2016) Philippos Peidis et al.   Aging-US

Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia

(2011) Darya Habibi et al.   INVESTIGATIONAL NEW DRUGS

Arginine Deficiency Causes Runting in the Suckling Period by Selectively Activating the Stress Kinase GCN2

(2011) Vincent Marion et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Nutrient Signaling and Body Weight Control in a Na+Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse

(2011) Angelika Bröer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

(2011) A. G. Hinnebusch   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene

(2011) Hung-Chieh Lee et al.   NUCLEIC ACIDS RESEARCH

Regulated ATF5 loss-of-function in adult mice blocks formation and causes regression/eradication of gliomas

(2011) A Arias et al.   ONCOGENE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

The binary switch between life and death of endoplasmic reticulum-stressed β cells

(2011) Christine M Oslowski et al.   Current Opinion in Endocrinology Diabetes and Obesity

Translation Reinitiation Relies on the Interaction between eIF3a/TIF32 and Progressively Folded cis-Acting mRNA Elements Preceding Short uORFs

(2011) Vanda Munzarová et al.   PLoS Genetics

Oxidized Phospholipids Regulate Expression of ATF4 and VEGF in Endothelial Cells via NRF2-Dependent Mechanism: Novel Point of Convergence Between Electrophilic and Unfolded Protein Stress Pathways

(2010) Taras Afonyushkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways

(2010) David Shahbazian et al.   CELL CYCLE

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

(2010) Y J Kang et al.   CELL DEATH AND DIFFERENTIATION

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Unfolded Protein Response (UPR) is activated during normal lens development

(2010) Zeynep Firtina et al.   GENE EXPRESSION PATTERNS

Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response

(2010) Souvik Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

The Role of Protein Kinase R in the Interferon Response

(2010) Agnieszka Pindel et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Leukoencephalopathy With Vanishing White Matter: A Review

(2010) Marianna Bugiani et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct 5′ UTRs regulate XIAP expression under normal growth conditions and during cellular stress

(2010) Alura Riley et al.   NUCLEIC ACIDS RESEARCH

Regulation of autophagy by ATF4 in response to severe hypoxia

(2010) T Rzymski et al.   ONCOGENE

Wolcott-Rallison syndrome

(2010) Cécile Julier et al.   Orphanet Journal of Rare Diseases

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells

(2009) Sung Hoon Back et al.   Cell Metabolism

Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

(2009) J. Seo et al.   DIABETES

Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress

(2009) Hyeon-Ok Jin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes

(2009) I. R. Powley et al.   GENES & DEVELOPMENT

Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p

(2009) John M. Zaborske et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase

(2009) Piyawan Bunpo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Endoplasmic Reticulum Stress-induced Cell Death by ATF4 in Neuroectodermal Tumor Cells

(2009) Jane L. Armstrong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Upstream Open Reading Frame Regulates Translation of GADD34 during Cellular Stresses That Induce eIF2α Phosphorylation

(2009) Yun-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions

(2009) Yi-Jiun Chen et al.   NUCLEIC ACIDS RESEARCH

eIF2α kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

(2009) An N. Dang Do et al.   PHYSIOLOGICAL GENOMICS

Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress

(2009) Mira M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation

(2008) S. S. Palii et al.   AMINO ACIDS

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism

Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice

(2008) Seiichi Oyadomari et al.   Cell Metabolism

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators

(2008) D. Thomas Rutkowski et al.   DEVELOPMENTAL CELL

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA

(2008) B. Szamecz et al.   GENES & DEVELOPMENT

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain

(2008) Simone Bittencourt et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The transcription factor ATF5: role in neurodevelopment and neural tumors

(2008) Lloyd A. Greene et al.   JOURNAL OF NEUROCHEMISTRY

A Network of Hydrophobic Residues Impeding Helix  C Rotation Maintains Latency of Kinase Gcn2, Which Phosphorylates the   Subunit of Translation Initiation Factor 2

(2008) A. Garriz et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors

(2008) Stefan Rothenburg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Different Effect of Proteasome Inhibition on Vesicular Stomatitis Virus and Poliovirus Replication

(2008) Nickolay Neznanov et al.   PLoS One

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY