Role of transcription factors in the transdifferentiation of pancreatic islet cells

The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression

(2014) Christopher Benner et al.   BMC GENOMICS

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy

(2014) Zhiyu Wang et al.   Cell Metabolism

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

The MafA Transcription Factor Becomes Essential to Islet β-Cells Soon After Birth

(2014) Yan Hang et al.   DIABETES

Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map

(2014) E. Bernal-Mizrachi et al.   DIABETES

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

(2014) Alireza Rezania et al.   NATURE BIOTECHNOLOGY

Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants

(2014) Lorenzo Pasquali et al.   NATURE GENETICS

Making β Cells from Adult Cells Within the Pancreas

(2013) Philippe A. Lysy et al.   Current Diabetes Reports

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Conversion of Mature Human  -Cells Into Glucagon-Producing  -Cells

(2013) H. S. Spijker et al.   DIABETES

From pancreatic islet formation to beta-cell regeneration

(2013) Nouha Ben-Othman et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Epigenomic plasticity enables human pancreatic α to β cell reprogramming

(2013) Nuria C. Bramswig et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreatic α-Cell Specific Deletion of Mouse Arx Leads to α-Cell Identity Loss

(2013) Crystal L. Wilcox et al.   PLoS One

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

(2013) Brandon L. Taylor et al.   Cell Reports

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

(2012) Masaki Kobayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Identification and analysis of murine pancreatic islet enhancers

(2012) B. R. Tennant et al.   DIABETOLOGIA

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Research Resource: The Pdx1 Cistrome of Pancreatic Islets

(2012) Cynthia Khoo et al.   MOLECULAR ENDOCRINOLOGY

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Urocortin 3 Marks Mature Human Primary and Embryonic Stem Cell-Derived Pancreatic Alpha and Beta Cells

(2012) Talitha van der Meulen et al.   PLoS One

Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage

(2011) Simon Kordowich et al.   BMC DEVELOPMENTAL BIOLOGY

Hormonal Regulation of Hepatic Glucose Production in Health and Disease

(2011) Hua V. Lin et al.   Cell Metabolism

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression

(2011) Teresa L. Mastracci et al.   DEVELOPMENTAL BIOLOGY

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues

(2011) Hua V. Lin et al.   DIABETES

Transcriptional regulation of α-cell differentiation

(2011) N. C. Bramswig et al.   DIABETES OBESITY & METABOLISM

Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion

(2011) Y. Gosmain et al.   DIABETES OBESITY & METABOLISM

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

Nkx2.2 repressor complex regulates islet  -cell specification and prevents  -to- -cell reprogramming

(2011) J. B. Papizan et al.   GENES & DEVELOPMENT

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

(2011) Olivia G Kelly et al.   NATURE BIOTECHNOLOGY

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

MafA and MafB Regulate Genes Critical to  -Cells in a Unique Temporal Manner

(2010) I. Artner et al.   DIABETES

α Cell–Specific Men1 Ablation Triggers the Transdifferentiation of Glucagon-Expressing Cells and Insulinoma Development

(2010) Jieli Lu et al.   GASTROENTEROLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Myc directly induces both impaired insulin secretion and loss of β-cell mass, independently of hyperglycemia in vivo

(2010) Linda Cheung et al.   Islets

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas

(2009) A. Du et al.   DIABETES

Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1

(2009) T. Kitamura et al.   MOLECULAR AND CELLULAR BIOLOGY

Epithelial-Mesenchymal Transition in Cells Expanded In Vitro from Lineage-Traced Adult Human Pancreatic Beta Cells

(2009) Holger A. Russ et al.   PLoS One

pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

(2008) Maureen Gannon et al.   DEVELOPMENTAL BIOLOGY

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Identification of Arx transcriptional targets in the developing basal forebrain

(2008) Carl T. Fulp et al.   HUMAN MOLECULAR GENETICS

Tumour suppressor menin is essential for development of the pancreatic endocrine cells

(2008) Sandra Fontanière et al.   JOURNAL OF ENDOCRINOLOGY

Generation and Characterization of Ptf1a Antiserum and Localization of Ptf1a in Relation to Nkx6.1 and Pdx1 During the Earliest Stages of Mouse Pancreas Development

(2008) Jacob Hald et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

(2007) Manuel C. Lemos et al.   HUMAN MUTATION