A causal link between oxidative stress and inflammation in cardiovascular and renal complications of diabetes

Rationale and protocol of the Study Of diabetic Nephropathy with AtRasentan (SONAR) trial: A clinical trial design novel to diabetic nephropathy

(2018) Hiddo J. L. Heerspink et al.   DIABETES OBESITY & METABOLISM

Interaction between p22 phox and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation

(2018) Melinda Zana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice

(2018) Yadong Zhai et al.   MOLECULES

Study of the NLRP3 inflammasome component genes and downstream cytokines in patients with type 2 diabetes mellitus with carotid atherosclerosis

(2017) Junli Lee et al.   Lipids in Health and Disease

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial DNA damage and vascular function in patients with diabetes mellitus and atherosclerotic cardiovascular disease

(2016) Jessica L. Fetterman et al.   Cardiovascular Diabetology

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE-/- mice

(2016) E. Di Marco et al.   CLINICAL SCIENCE

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Multiple benefits of targeting inflammation in the treatment of type 2 diabetes

(2016) Marc Y. Donath   DIABETOLOGIA

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

(2016) Elyse Di Marco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase

(2016) Xiaoyong Tong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence

(2016) I-Ching Tsai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Of Inflammasomes and Alarmins: IL-1  and IL-1  in Kidney Disease

(2016) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipoprotein redox status evaluation as a marker of cardiovascular disease risk in patients with inflammatory disease

(2016) Anca Ungurianu et al.   Molecular Medicine Reports

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

(2016) Hong Feng et al.   Journal of Diabetes Research

Soluble receptor for advanced glycation end products and the risk for incident heart failure: The Atherosclerosis Risk in Communities Study

(2015) Mariana Lazo et al.   AMERICAN HEART JOURNAL

Allopurinol and Progression of CKD and Cardiovascular Events: Long-term Follow-up of a Randomized Clinical Trial

(2015) Marian Goicoechea et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular RemodelingSignificance

(2015) Stephen P. Gray et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of NLRP3 in subcutaneous adipose tissue is associated with coronary atherosclerosis

(2015) Sachiko Bando et al.   ATHEROSCLEROSIS

Human monocytes and macrophages express NADPH oxidase 5; a potential source of reactive oxygen species in atherosclerosis

(2015) Adrian Manea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

(2015) K Palikaras et al.   CELL DEATH AND DIFFERENTIATION

Are reactive oxygen species still the basis for diabetic complications?

(2015) Elyse Di Marco et al.   CLINICAL SCIENCE

Relationship Between Levels of Advanced Glycation End Products and Their Soluble Receptor and Adverse Outcomes in Adults With Type 2 Diabetes

(2015) Merlin C. Thomas et al.   DIABETES CARE

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

(2015) Jay C. Jha et al.   DIABETOLOGIA

The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

(2015) E. Anvari et al.   FREE RADICAL RESEARCH

Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the antiatherosclerosis effect of oleanolic acid

(2015) Qixiao Jiang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

(2015) Devy Deliyanti et al.   Journal of Neuroinflammation

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

(2015) Y.-H. You et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1·9 million people

(2015) Anoop Dinesh Shah et al.   LANCET

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes

(2015) Gina Manda et al.   MEDIATORS OF INFLAMMATION

Increased Oxidation as an Additional Mechanism Underlying Reduced Clot Permeability and Impaired Fibrinolysis in Type 2 Diabetes

(2015) Anna Lados-Krupa et al.   Journal of Diabetes Research

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

(2014) Anna M.D. Watson et al.   ATHEROSCLEROSIS

Vascular wall extracellular matrix proteins and vascular diseases

(2014) Junyan Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy

(2014) Pan Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C

(2014) Lucia Flores-Contreras et al.   BMC GASTROENTEROLOGY

LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis

(2014) Z. Ding et al.   CARDIOVASCULAR RESEARCH

Pentoxifylline in Heart Failure: A Meta-Analysis of Clinical Trials

(2014) Sébastien Champion et al.   Cardiovascular Therapeutics

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

(2014) Christine Koulis et al.   CLINICAL SCIENCE

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of Pentoxifylline on Renal Function and Urinary Albumin Excretion in Patients with Diabetic Kidney Disease: The PREDIAN Trial

(2014) J. F. Navarro-Gonzalez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

High fat diet feeding results in gender specific steatohepatitis and inflammasome activation

(2014) Michal Ganz   WORLD JOURNAL OF GASTROENTEROLOGY

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Vascular Pathology

(2013) Anna Konior et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4

(2013) Rafał Kozieł et al.   BIOCHEMICAL JOURNAL

Probucol Inhibited Nox2 Expression and Attenuated Podocyte Injury in Type 2 Diabetic Nephropathy of db/db Mice

(2013) Guangyu Zhou et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: Results of secondary endpoints from a randomized, placebo-controlled trial

(2013) J. Hensen et al.   DIABETES & METABOLISM

The Role of Nrf2 in the Attenuation of Cardiovascular Disease

(2013) Danielle J. Reuland et al.   EXERCISE AND SPORT SCIENCES REVIEWS

NLRP3 Inflammasomes Show High Expression in Aorta of Patients with Atherosclerosis

(2013) Fei Zheng et al.   Heart Lung and Circulation

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression

(2013) C. E. Holterman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

A novel mechanism of NALP3 inducing ischemia reperfusion injury by activating MAPK pathway in acute renal failure

(2013) J.L. Hao et al.   MEDICAL HYPOTHESES

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy

(2013) Linda F. Fried et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenesis and Novel Treatment from the Mouse Model of Type 2 Diabetic Nephropathy

(2013) Masako Furukawa et al.   TheScientificWorldJOURNAL

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

NOX5 Expression Is Increased in Intramyocardial Blood Vessels and Cardiomyocytes after Acute Myocardial Infarction in Humans

(2012) Nynke E. Hahn et al.   AMERICAN JOURNAL OF PATHOLOGY

Adverse Alterations in Mitochondrial Function Contribute to Type 2 Diabetes Mellitus–Related Endothelial Dysfunction in Humans

(2012) Tinoy J. Kizhakekuttu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arterial and Venous Endothelia Display Differential Functional Fractalkine (CX 3 CL1) Expression by Angiotensin-II

(2012) Cristina Rius et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

(2012) Yugang Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Renoprotective effects of a novel Nox1/4 inhibitor in a mouse model of Type 2 diabetes

(2012) Mona Sedeek et al.   CLINICAL SCIENCE

Urinary Proteomics for Early Diagnosis in Diabetic Nephropathy

(2012) P. Zurbig et al.   DIABETES

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent

(2012) Tomonori Aoyama et al.   HEPATOLOGY

Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion

(2012) Pei-Chun Liao et al.   INFLAMMATION RESEARCH

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

(2012) Elise L. Donovan et al.   Oxidative Medicine and Cellular Longevity

Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation

(2012) Chuang Wang et al.   PLoS One

Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1

(2012) W. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Bardoxolone Methyl on Kidney Function in Patients with T2D and Stage 3b–4 CKD

(2011) Pablo E. Pergola et al.   AMERICAN JOURNAL OF NEPHROLOGY

Molecular regulation of NADPH oxidase 5 via the MAPK pathway

(2011) D. Pandey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide Production

(2011) Feng Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors

(2011) Francesca Gaggini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus

(2011) Sherene M. Shenouda et al.   CIRCULATION

Peripheral blood level alterations of MMP-2 and MMP-9 in patients with chronic kidney disease on conservative treatment and on hemodialysis

(2011) Krystyna Pawlak et al.   CLINICAL BIOCHEMISTRY

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice

(2011) S. Parathath et al.   DIABETES

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

(2011) S. Kume et al.   DIABETES

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy: FIG. 1.

(2011) Judy B. de Haan   DIABETES

Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

(2011) Hongting Zheng et al.   DIABETES

Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis

(2011) G. Rao et al.   DIABETOLOGIA

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins

(2011) Fatemeh Moheimani et al.   Experimental Diabetes Research

Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Edwin J. P. van Asseldonk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Addition of Atrasentan to Renin-Angiotensin System Blockade Reduces Albuminuria in Diabetic Nephropathy

(2011) D. E. Kohan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pirfenidone for Diabetic Nephropathy

(2011) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

(2011) Jeffrey L. Barnes et al.   KIDNEY INTERNATIONAL

Calcium/Calmodulin-Dependent Kinase II Mediates the Phosphorylation and Activation of NADPH Oxidase 5

(2011) D. Pandey et al.   MOLECULAR PHARMACOLOGY

Bardoxolone Methyl and Kidney Function in CKD with Type 2 Diabetes

(2011) Pablo E. Pergola et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiovascular and non-cardiovascular mortality in dialysis patients: where is the link?

(2011) Kitty J. Jager et al.   Kidney International Supplements

Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells

(2010) Thian Kui Tan et al.   AMERICAN JOURNAL OF PATHOLOGY

Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ

(2010) Balu K. Chacko et al.   BIOCHEMICAL JOURNAL

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells

(2010) Augusto C. Montezano et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by TGFβ1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat

(2010) XiaoYong Tong et al.   CIRCULATION RESEARCH

Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes

(2010) Tetsuro Ago et al.   CIRCULATION RESEARCH

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

(2010) Augusto C. Montezano et al.   CLINICAL SCIENCE

First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

(2010) Benoı̂t Laleu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Avosentan for Overt Diabetic Nephropathy

(2010) J. F.E. Mann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart

(2010) J. Kuroda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes

(2010) Michael E. Widlansky et al.   Translational Research

Nox5 and the Regulation of Cellular Function

(2009) David J.R. Fulton   ANTIOXIDANTS & REDOX SIGNALING

Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells

(2009) Claudia Goettsch et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells

(2009) Koichi Sugimoto et al.   CARDIOVASCULAR RESEARCH

Aldosterone Antagonists for Preventing the Progression of Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2009) S. D. Navaneethan et al.   Clinical Journal of the American Society of Nephrology

The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes

(2009) P.-H. Groop et al.   DIABETES

The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice

(2009) A. M. D. Watson et al.   DIABETOLOGIA

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of irreversibly glycated LDL in human vascular smooth muscle cells: lipid loading, oxidative and inflammatory stress

(2009) Anca V. Sima et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pirfenidone Is Renoprotective in Diabetic Kidney Disease

(2009) S. P. RamachandraRao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary Peptidome May Predict Renal Function Decline in Type 1 Diabetes and Microalbuminuria

(2009) M. L. Merchant et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

(2009) M. T. Coughlan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal and Retinal Effects of Enalapril and Losartan in Type 1 Diabetes

(2009) Michael Mauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction

(2008) Thomas Münzel et al.   ANNALS OF MEDICINE

Advanced Oxidation Protein Products Activate Vascular Endothelial Cells via a RAGE-Mediated Signaling Pathway

(2008) Zhi Jian Guo et al.   ANTIOXIDANTS & REDOX SIGNALING

Paradoxical Activation of Endothelial Nitric Oxide Synthase by NADPH Oxidase

(2008) Qian Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Characterization of metalloprotease cleavage products of human articular cartilage

(2008) Eugene Y. Zhen et al.   ARTHRITIS AND RHEUMATISM

Glycoxidized LDL increases lectin-like oxidized low density lipoprotein receptor-1 in diabetes mellitus

(2008) Sammy W.M. Shiu et al.   ATHEROSCLEROSIS

Nuclear Factor E2-Related Factor 2-Dependent Myocardiac Cytoprotection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   Cardiovascular Toxicology

Receptor for Advanced Glycation End Products (RAGE) Deficiency Attenuates the Development of Atherosclerosis in Diabetes

(2008) A. Soro-Paavonen et al.   DIABETES

The HMG-CoA reductase inhibitor rosuvastatin and the angiotensin receptor antagonist candesartan attenuate atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes via effects on advanced glycation, oxidative stress and inflammation

(2008) A. C. Calkin et al.   DIABETOLOGIA

Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells

(2008) Desmond B. Jay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Endothelin-1 in Clinical Hypertension

(2008) Neeraj Dhaun et al.   HYPERTENSION

Calcium-Dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease

(2008) Tomasz J. Guzik et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

(2008) Johannes FE Mann et al.   LANCET

Attenuation of diabetic nephropathy by tocotrienol: Involvement of NFkB signaling pathway

(2008) Anurag Kuhad et al.   LIFE SCIENCES

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade on Streptozotocin-Induced Diabetic Nephropathy

(2008) Saniye Sen et al.   RENAL FAILURE