Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγnull(NSG) mice engrafted with human thymus and autologous haematopoietic stem cells

Full reconstitution of human platelets in humanized mice after macrophage depletion

(2012) Z. Hu et al.   BLOOD

Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r null mice is enhanced by transgenic expression of membrane-bound human SCF

(2012) M. A. Brehm et al.   BLOOD

Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice

(2012) Smita Jaiswal et al.   IMMUNOLOGY

Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice

(2012) B. R. Long et al.   JOURNAL OF VIROLOGY

An Epstein-Barr Virus (EBV) Mutant with Enhanced BZLF1 Expression Causes Lymphomas with Abortive Lytic EBV Infection in a Humanized Mouse Model

(2012) S.-D. Ma et al.   JOURNAL OF VIROLOGY

IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice

(2012) P W Denton et al.   Mucosal Immunology

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

(2012) Matthew B. Greenblatt et al.   PLoS One

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

A Model for Personalized in Vivo Analysis of Human Immune Responsiveness

(2012) H. Kalscheuer et al.   Science Translational Medicine

Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice

(2012) T. E. Dudek et al.   Science Translational Medicine

Systemic Human T Cell Developmental Processes in Humanized Mice Cotransplanted With Human Fetal Thymus/Liver Tissue and Hematopoietic Stem Cells

(2012) Sung-Yeon Joo et al.   TRANSPLANTATION

T-Cell Tolerance: Central and Peripheral

(2012) Y. Xing et al.   Cold Spring Harbor Perspectives in Biology

Human Breast Milk and Antiretrovirals Dramatically Reduce Oral HIV-1 Transmission in BLT Humanized Mice

(2012) Angela Wahl et al.   PLoS Pathogens

Humanized mice for the study of type 1 and type 2 diabetes

(2011) Dale L. Greiner et al.   Annals of the New York Academy of Sciences

Humanized mice as a preclinical tool for infectious disease and biomedical research

(2011) Leonard D. Shultz et al.   Annals of the New York Academy of Sciences

Macrophages prevent human red blood cell reconstitution in immunodeficient mice

(2011) Z. Hu et al.   BLOOD

Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγnull H2-Ab1 tm1Gru Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease

(2011) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells

(2011) Subhabrata Biswas et al.   IMMUNOLOGY

Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

(2011) Lee Adam Wheeler et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Natural Regulatory T Cell Development, Suppressive Function, and Postthymic Maturation in a Humanized Mouse Model

(2011) T. Onoe et al.   JOURNAL OF IMMUNOLOGY

HIV Latency in the Humanized BLT Mouse

(2011) M. D. Marsden et al.   JOURNAL OF VIROLOGY

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Analysis of the CD1 Antigen Presenting System in Humanized SCID Mice

(2011) Jennifer L. Lockridge et al.   PLoS One

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells

(2011) D. N. Vatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient peripheral construction of functional human regulatory CD4+CD25highFoxp3+ T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34+ cells

(2011) Kaizhong Duan et al.   TRANSPLANT IMMUNOLOGY

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

(2011) Tim Willinger et al.   TRENDS IN IMMUNOLOGY

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Comparison of human cord blood engraftment between immunocompromised mouse strains

(2010) S. P. McDermott et al.   BLOOD

Parameters for establishing humanized mouse models to study human immunity: Analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rγnull mutation

(2010) Michael A. Brehm et al.   CLINICAL IMMUNOLOGY

Homeostatic Expansion and Phenotypic Conversion of Human T Cells Depend on Peripheral Interactions with APCs

(2010) T. Onoe et al.   JOURNAL OF IMMUNOLOGY

Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT Mice

(2010) Paul W. Denton et al.   PLoS One

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans

(2010) J. E. Mold et al.   SCIENCE

NOD-scid IL2rγnull Mouse Model of Human Skin Transplantation and Allograft Rejection

(2010) Waldemar J. Racki et al.   TRANSPLANTATION

New perspectives on the biology of acute GVHD

(2009) S Paczesny et al.   BONE MARROW TRANSPLANTATION

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

(2009) Nicolas Legrand et al.   Cell Host & Microbe

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Intra-bone marrow transplantation of human CD34+ cells into NOD/LtSz-scid IL-2rγnull mice permits multilineage engraftment without previous irradiation

(2009) Clara Bueno et al.   CYTOTHERAPY

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Engineering Antigen-Specific T Cells from Genetically Modified Human Hematopoietic Stem Cells in Immunodeficient Mice

(2009) Scott G. Kitchen et al.   PLoS One

Development of Functional Human Immune System With the Transplantations of Human Fetal Liver/Thymus Tissues and Expanded Hematopoietic Stem Cells in RAG2−/−γc−/− MICE

(2009) S.-Y. Joo et al.   TRANSPLANTATION PROCEEDINGS

Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model

(2008) N. Tonomura et al.   BLOOD

Pig islet xenograft rejection in a mouse model with an established human immune system

(2008) Noriko Tonomura et al.   XENOTRANSPLANTATION

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene

(2007) Marie King et al.   CLINICAL IMMUNOLOGY