Making an effective switch at the kinetochore by phosphorylation and dephosphorylation

Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint

(2012) Geert J. P. L. Kops et al.   CHROMOSOMA

Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex

(2012) Judith Zich et al.   CURRENT BIOLOGY

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments

(2012) Jens C. Schmidt et al.   DEVELOPMENTAL CELL

Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C

(2012) Helene Labit et al.   EMBO JOURNAL

Molecular architecture of vertebrate kinetochores

(2012) Kozo Takeuchi et al.   EXPERIMENTAL CELL RESEARCH

Cell division control by the Chromosomal Passenger Complex

(2012) Maike S. van der Waal et al.   EXPERIMENTAL CELL RESEARCH

A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint

(2012) D. R. Matson et al.   GENES & DEVELOPMENT

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression

(2012) Robin M. Ricke et al.   JOURNAL OF CELL BIOLOGY

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores

(2012) Claudia Wurzenberger et al.   JOURNAL OF CELL BIOLOGY

Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction

(2012) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase-1 regulates kinetochore–microtubule dynamics and spindle checkpoint silencing

(2012) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation

(2012) Fangwei Wang et al.   JOURNAL OF CELL BIOLOGY

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

(2012) Anna De Antoni et al.   JOURNAL OF CELL BIOLOGY

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore

(2012) Julien Espeut et al.   JOURNAL OF CELL BIOLOGY

CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint

(2012) Yige Guo et al.   JOURNAL OF CELL BIOLOGY

Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast

(2012) G. J. Buttrick et al.   JOURNAL OF CELL SCIENCE

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation

(2012) Emily A. Hood et al.   MOLECULAR BIOLOGY OF THE CELL

The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation

(2012) Scott A. Foster et al.   MOLECULAR CELL

Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface

(2012) A. Arockia Jeyaprakash et al.   MOLECULAR CELL

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Human aneuploidy: mechanisms and new insights into an age-old problem

(2012) So I. Nagaoka et al.   NATURE REVIEWS GENETICS

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

(2012) Emily A. Foley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

(2012) Kristina Uzunova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deformations Within Moving Kinetochores Reveal Different Sites of Active and Passive Force Generation

(2012) S. Dumont et al.   SCIENCE

The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres

(2012) Mar Carmena et al.   PLOS BIOLOGY

Complete Kinetochore Tracking Reveals Error-Prone Homologous Chromosome Biorientation in Mammalian Oocytes

(2011) Tomoya S. Kitajima et al.   CELL

Induced Ectopic Kinetochore Assembly Bypasses the Requirement for CENP-A Nucleosomes

(2011) Karen E. Gascoigne et al.   CELL

The Spatial Arrangement of Chromosomes during Prometaphase Facilitates Spindle Assembly

(2011) Valentin Magidson et al.   CELL

The ABCs of CENPs

(2011) Marinela Perpelescu et al.   CHROMOSOMA

Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase

(2011) Kevan J. Salimian et al.   CURRENT BIOLOGY

A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis

(2011) Fangwei Wang et al.   CURRENT BIOLOGY

KNL1/Spc105 Recruits PP1 to Silence the Spindle Assembly Checkpoint

(2011) Jessica S. Rosenberg et al.   CURRENT BIOLOGY

Mps1 at kinetochores is essential for female mouse meiosis I

(2011) K. Hached et al.   DEVELOPMENT

Aurora B Regulates Formin mDia3 in Achieving Metaphase Chromosome Alignment

(2011) Lina Cheng et al.   DEVELOPMENTAL CELL

Spindle Checkpoint Silencing Requires Association of PP1 to Both Spc7 and Kinesin-8 Motors

(2011) John C. Meadows et al.   DEVELOPMENTAL CELL

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Characterization of Spindle Checkpoint Kinase Mps1 Reveals Domain with Functional and Structural Similarities to Tetratricopeptide Repeat Motifs of Bub1 and BubR1 Checkpoint Kinases

(2011) Semin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins

(2011) Aussie Suzuki et al.   JOURNAL OF CELL BIOLOGY

The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment

(2011) Anja K. Dunsch et al.   JOURNAL OF CELL BIOLOGY

Point centromeres contain more than a single centromere-specific Cse4 (CENP-A) nucleosome

(2011) Josh Lawrimore et al.   JOURNAL OF CELL BIOLOGY

CENP-A exceeds microtubule attachment sites in centromere clusters of both budding and fission yeast

(2011) Valerie C. Coffman et al.   JOURNAL OF CELL BIOLOGY

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit

(2011) F. G. Westhorpe et al.   JOURNAL OF CELL SCIENCE

BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner

(2011) Pablo Lara-Gonzalez et al.   JOURNAL OF CELL SCIENCE

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

Protein Interaction Domain Mapping of Human Kinetochore Protein Blinkin Reveals a Consensus Motif for Binding of Spindle Assembly Checkpoint Proteins Bub1 and BubR1

(2011) T. Kiyomitsu et al.   MOLECULAR AND CELLULAR BIOLOGY

Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores

(2011) James M. Kasuboski et al.   MOLECULAR BIOLOGY OF THE CELL

The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement

(2011) John G. Tooley et al.   MOLECULAR BIOLOGY OF THE CELL

Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31comet

(2011) Luying Jia et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint

(2011) Randy Wei et al.   MOLECULAR BIOLOGY OF THE CELL

In vitro centromere and kinetochore assembly on defined chromatin templates

(2011) Annika Guse et al.   NATURE

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

(2011) Mardo Kõivomägi et al.   NATURE

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

(2011) Jörg Mansfeld et al.   NATURE CELL BIOLOGY

Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate

(2011) J.-E. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

(2011) A. Teichner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centromere-tethered Mps1 pombe homolog (Mph1) kinase is a sufficient marker for recruitment of the spindle checkpoint protein Bub1, but not Mad1

(2011) D. Ito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

(2011) J. Alexander et al.   Science Signaling

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Aurora Kinases and Protein Phosphatase 1 Mediate Chromosome Congression through Regulation of CENP-E

(2010) Yumi Kim et al.   CELL

Dual Detection of Chromosomes and Microtubules by the Chromosomal Passenger Complex Drives Spindle Assembly

(2010) Boo Shan Tseng et al.   DEVELOPMENTAL CELL

Kinetochore–microtubule interactions: steps towards bi-orientation

(2010) Tomoyuki U Tanaka   EMBO JOURNAL

Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore–microtubule attachments

(2010) Hongchang Li et al.   EMBO JOURNAL

CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity

(2010) Amity L Manning et al.   EMBO JOURNAL

Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres

(2010) Y. Tanno et al.   GENES & DEVELOPMENT

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

(2010) R. Gassmann et al.   GENES & DEVELOPMENT

CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment

(2010) Shasha Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

(2010) Hyunju Ryu et al.   JOURNAL OF CELL BIOLOGY

Sds22 regulates aurora B activity and microtubule–kinetochore interactions at mitosis

(2010) Markus Posch et al.   JOURNAL OF CELL BIOLOGY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Aurora B kinase controls the targeting of the Astrin–SKAP complex to bioriented kinetochores

(2010) Jens C. Schmidt et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complex

(2010) Fabienne Lampert et al.   JOURNAL OF CELL BIOLOGY

Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B

(2010) Jerry F. Tien et al.   JOURNAL OF CELL BIOLOGY

The MIS12 complex is a protein interaction hub for outer kinetochore assembly

(2010) Arsen Petrovic et al.   JOURNAL OF CELL BIOLOGY

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis

(2010) D. Perera et al.   JOURNAL OF CELL SCIENCE

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Tension directly stabilizes reconstituted kinetochore-microtubule attachments

(2010) Bungo Akiyoshi et al.   NATURE

Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation

(2010) Tatsuya Tsukahara et al.   NATURE

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

(2010) Gregory M. Alushin et al.   NATURE

Chemical Genetic Inhibition of Mps1 in Stable Human Cell Lines Reveals Novel Aspects of Mps1 Function in Mitosis

(2010) Tale Sliedrecht et al.   PLoS One

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

The Kinetochore and the Centromere: A Working Long Distance Relationship

(2009) Marcin R. Przewloka et al.   Annual Review of Genetics

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

ICIS and Aurora B Coregulate the Microtubule Depolymerase Kif2a

(2009) Anne L. Knowlton et al.   CURRENT BIOLOGY

Cdk1 Negatively Regulates Midzone Localization of the Mitotic Kinesin Mklp2 and the Chromosomal Passenger Complex

(2009) Stefan Hümmer et al.   CURRENT BIOLOGY

Protein Phosphatase 1 Regulates Exit from the Spindle Checkpoint in Budding Yeast

(2009) Benjamin A. Pinsky et al.   CURRENT BIOLOGY

A Novel Protein Phosphatase 1-Dependent Spindle Checkpoint Silencing Mechanism

(2009) Vincent Vanoosthuyse et al.   CURRENT BIOLOGY

Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view

(2009) Alexander E Kelly et al.   CURRENT OPINION IN CELL BIOLOGY

BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase

(2009) Liviu A. Malureanu et al.   DEVELOPMENTAL CELL

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

(2009) Anita Kulukian et al.   DEVELOPMENTAL CELL

Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling

(2009) Stefan Kemmler et al.   EMBO JOURNAL

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis

(2009) Eunhee Choi et al.   EMBO JOURNAL

Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit

(2009) B. Akiyoshi et al.   GENES & DEVELOPMENT

Analysis of Ipl1-Mediated Phosphorylation of the Ndc80 Kinetochore Protein in Saccharomyces cerevisiae

(2009) Bungo Akiyoshi et al.   GENETICS

Kinetochore stretching inactivates the spindle assembly checkpoint

(2009) Kazuhiko S.K. Uchida et al.   JOURNAL OF CELL BIOLOGY

Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

(2009) Thomas J. Maresca et al.   JOURNAL OF CELL BIOLOGY

Bub1 regulates chromosome segregation in a kinetochore-independent manner

(2009) Christiane Klebig et al.   JOURNAL OF CELL BIOLOGY

Kinetochore geometry defined by cohesion within the centromere

(2009) Takeshi Sakuno et al.   NATURE

Chromosome congression in the absence of kinetochore fibres

(2009) Shang Cai et al.   NATURE CELL BIOLOGY

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Phosphorylation of H2A by Bub1 Prevents Chromosomal Instability Through Localizing Shugoshin

(2009) S. A. Kawashima et al.   SCIENCE

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex

(2008) Claudio Ciferri et al.   CELL

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

(2008) Meelad M. Dawlaty et al.   CELL

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Kinetochore-Microtubule Attachment Relies on the Disordered N-Terminal Tail Domain of Hec1

(2008) Geoffrey J. Guimaraes et al.   CURRENT BIOLOGY

Kinetochore Attachments Require an Interaction between Unstructured Tails on Microtubules and Ndc80Hec1

(2008) Stephanie A. Miller et al.   CURRENT BIOLOGY

The Kinesin-8 Motor Kif18A Suppresses Kinetochore Movements to Control Mitotic Chromosome Alignment

(2008) Jason Stumpff et al.   DEVELOPMENTAL CELL

The Spindle Checkpoint Functions of Mad3 and Mad2 Depend on a Mad3 KEN Box-mediated Interaction with Cdc20-Anaphase-promoting Complex (APC/C)

(2008) Matylda Sczaniecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment

(2008) Dileep Varma et al.   JOURNAL OF CELL BIOLOGY

Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly

(2008) Michael J. Emanuele et al.   JOURNAL OF CELL BIOLOGY

Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line

(2008) Zuojun Yue et al.   JOURNAL OF CELL BIOLOGY

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

(2008) Haomin Huang et al.   JOURNAL OF CELL BIOLOGY

The Human Spindle Assembly Checkpoint Protein Bub3 Is Required for the Establishment of Efficient Kinetochore–Microtubule Attachments

(2008) Elsa Logarinho et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphorylation Relieves Autoinhibition of the Kinetochore Motor Cenp-E

(2008) Julien Espeut et al.   MOLECULAR CELL

Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation

(2008) Daniel R. Gestaut et al.   NATURE CELL BIOLOGY

Centromeric Aurora-B Activation Requires TD-60, Microtubules, and Substrate Priming Phosphorylation

(2008) S. E. Rosasco-Nitcher et al.   SCIENCE

Protein Metamorphosis: The Two-State Behavior of Mad2

(2008) Xuelian Luo et al.   STRUCTURE

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

(2008) Maojun Yang et al.   PLOS BIOLOGY

CENP-O Class Proteins Form a Stable Complex and Are Required for Proper Kinetochore Function

(2007) Tetsuya Hori et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular architecture of the kinetochore–microtubule interface

(2007) Iain M. Cheeseman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY