Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation

Structure–activity relationship study of beta-carboline derivatives as haspin kinase inhibitors

(2012) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint

(2012) D. R. Matson et al.   GENES & DEVELOPMENT

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

(2012) Anna De Antoni et al.   JOURNAL OF CELL BIOLOGY

Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres

(2012) Ewa Niedzialkowska et al.   MOLECULAR BIOLOGY OF THE CELL

CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment

(2012) Elsa Logarinho et al.   NATURE CELL BIOLOGY

A General Framework for Inhibitor Resistance in Protein Kinases

(2011) Deborah Balzano et al.   CHEMISTRY & BIOLOGY

Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase

(2011) Kevan J. Salimian et al.   CURRENT BIOLOGY

A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis

(2011) Fangwei Wang et al.   CURRENT BIOLOGY

Cohesion Fatigue Induces Chromatid Separation in Cells Delayed at Metaphase

(2011) John R. Daum et al.   CURRENT BIOLOGY

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

(2011) Stefano Santaguida et al.   EMBO JOURNAL

Phosphorylation at serine 331 is required for Aurora B activation

(2011) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics

(2011) Nadia Hégarat et al.   JOURNAL OF CELL BIOLOGY

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient

(2011) Enxiu Wang et al.   JOURNAL OF CELL BIOLOGY

Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

(2011) K. F. DeLuca et al.   JOURNAL OF CELL SCIENCE

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

(2011) D Huertas et al.   ONCOGENE

Uncoordinated Loss of Chromatid Cohesion Is a Common Outcome of Extended Metaphase Arrest

(2011) Deanna Stevens et al.   PLoS One

Examining the dynamics of chromosomal passenger complex (CPC)-dependent phosphorylation during cell division

(2011) L. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for the Recognition of Phosphorylated Histone H3 by the Survivin Subunit of the Chromosomal Passenger Complex

(2011) A. Arockia Jeyaprakash et al.   STRUCTURE

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Structure–activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors

(2010) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Centromere localization of INCENP-Aurora B is sufficient to support spindle checkpoint function

(2010) Markus Becker et al.   CELL CYCLE

Dual Detection of Chromosomes and Microtubules by the Chromosomal Passenger Complex Drives Spindle Assembly

(2010) Boo Shan Tseng et al.   DEVELOPMENTAL CELL

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Driving the cell cycle with a minimal CDK control network

(2010) Damien Coudreuse et al.   NATURE

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B

(2010) Alexander E. Kelly et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

A Novel Protein Phosphatase 1-Dependent Spindle Checkpoint Silencing Mechanism

(2009) Vincent Vanoosthuyse et al.   CURRENT BIOLOGY

INCENP–aurora B interactions modulate kinase activity and chromosome passenger complex localization

(2009) Zhenjie Xu et al.   JOURNAL OF CELL BIOLOGY

Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments

(2009) Zhenye Yang et al.   JOURNAL OF CELL BIOLOGY

Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion

(2009) J. Dai et al.   JOURNAL OF CELL SCIENCE

Structure and functional characterization of the atypical human kinase haspin

(2009) J. Eswaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly

(2008) Michael J. Emanuele et al.   JOURNAL OF CELL BIOLOGY

Centromeric Aurora-B Activation Requires TD-60, Microtubules, and Substrate Priming Phosphorylation

(2008) S. E. Rosasco-Nitcher et al.   SCIENCE

The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells

(2008) Daniela A. Brito et al.   CELL MOTILITY AND THE CYTOSKELETON