Regulation of splicing by SR proteins and SR protein-specific kinases

Genome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing

(2013) Shatakshi Pandit et al.   MOLECULAR CELL

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

(2013) Supriya Sen et al.   Nature Communications

Spliceosome mutations involvingSRSF2,SF3B1, andU2AF35in chronic myelomonocytic leukemia: Prevalence, clinical correlates, and prognostic relevance

(2012) Mrinal M. Patnaik et al.   AMERICAN JOURNAL OF HEMATOLOGY

SRPK1 inhibitionin vivo: modulation of VEGF splicing and potential treatment for multiple diseases: Figure 1

(2012) Sebastian Oltean et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nucleotide Release Sequences in the Protein Kinase SRPK1 Accelerate Substrate Phosphorylation

(2012) Brandon E. Aubol et al.   BIOCHEMISTRY

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML)

(2012) M. Meggendorfer et al.   BLOOD

SRSF2 mutations in primary myelofibrosis: significant clustering with IDH mutations and independent association with inferior overall and leukemia-free survival

(2012) T. L. Lasho et al.   BLOOD

The Cellular EJC Interactome Reveals Higher-Order mRNP Structure and an EJC-SR Protein Nexus

(2012) Guramrit Singh et al.   CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Interacting factors and cellular localization of SR protein-specific kinase Dsk1

(2012) Zhaohua Tang et al.   EXPERIMENTAL CELL RESEARCH

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

(2012) Rong Jia et al.   International Journal of Biological Sciences

The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes

(2012) B. J. Loh et al.   JOURNAL OF CELL SCIENCE

Complex Evolutionary Relationships Among Four Classes of Modular RNA-Binding Splicing Regulators in Eukaryotes: The hnRNP, SR, ELAV-Like and CELF Proteins

(2012) Yue Hang Tang et al.   JOURNAL OF MOLECULAR EVOLUTION

The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

(2012) Michal Cohen-Eliav et al.   JOURNAL OF PATHOLOGY

The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus

(2012) Zhihong Zhou et al.   MOLECULAR CELL

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

(2012) Olga Anczuków et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence

(2012) Y Tang et al.   ONCOGENE

Elevated Expression of the Serine-Arginine Protein Kinase 1 Gene in Ovarian Cancer and Its Role in Cisplatin Cytotoxicity In Vitro

(2012) Kunle Odunsi et al.   PLoS One

Abnormal Expression of the Pre-mRNA Splicing Regulators SRSF1, SRSF2, SRPK1 and SRPK2 in Non Small Cell Lung Carcinoma

(2012) Stephanie Gout et al.   PLoS One

Regulation of Mcl-1 by SRSF1 and SRSF5 in Cancer Cells

(2012) Hannah L. Gautrey et al.   PLoS One

Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms

(2012) S. Erkelenz et al.   RNA

Evolutionary Dynamics of Gene and Isoform Regulation in Mammalian Tissues

(2012) J. Merkin et al.   SCIENCE

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

(2012) Shipra Das et al.   Cell Reports

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

S6K1 Alternative Splicing Modulates Its Oncogenic Activity and Regulates mTORC1

(2012) Vered Ben-Hur et al.   Cell Reports

The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing

(2012) Erica A. Moehle et al.   PLoS Genetics

The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes

(2012) Minna-Liisa Änkö et al.   GENOME BIOLOGY

WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing

(2011) Elianna M. Amin et al.   CANCER CELL

An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming

(2011) Mathieu Gabut et al.   CELL

Epigenetics in Alternative Pre-mRNA Splicing

(2011) Reini F. Luco et al.   CELL

Asyn-anticonformational difference allows SRSF2 to recognize guanines and cytosines equally well

(2011) Gerrit M Daubner et al.   EMBO JOURNAL

Son maintains accurate splicing for a subset of human pre-mRNAs

(2011) Alok Sharma et al.   JOURNAL OF CELL SCIENCE

SON Controls Cell-Cycle Progression by Coordinated Regulation of RNA Splicing

(2011) Eun-Young Ahn et al.   MOLECULAR CELL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Functional consequences of developmentally regulated alternative splicing

(2011) Auinash Kalsotra et al.   NATURE REVIEWS GENETICS

Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly

(2011) S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DEGRADE, MOVE, REGROUP: signaling control of splicing proteins

(2011) Florian Heyd et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pre-mRNA splicing: where and when in the nucleus

(2011) Joonhee Han et al.   TRENDS IN CELL BIOLOGY

Pause locally, splice globally

(2011) Fernando Carrillo Oesterreich et al.   TRENDS IN CELL BIOLOGY

Understanding splicing regulation through RNA splicing maps

(2011) Joshua T. Witten et al.   TRENDS IN GENETICS

Evolution of SR protein and hnRNP splicing regulatory factors

(2011) Anke Busch et al.   Wiley Interdisciplinary Reviews-RNA

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin

(2010) Valerie Edmond et al.   EMBO JOURNAL

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

Phosphorylation mechanism and structure of serine-arginine protein kinases

(2010) Gourisankar Ghosh et al.   FEBS Journal

Serine-arginine protein kinases: a small protein kinase family with a large cellular presence

(2010) Thomas Giannakouros et al.   FEBS Journal

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

(2010) C. J. David et al.   GENES & DEVELOPMENT

A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins)

(2010) J. L. Manley et al.   GENES & DEVELOPMENT

Heat Shock-Induced SRSF10 Dephosphorylation Displays Thermotolerance Mediated by Hsp27

(2010) Y. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

SR Proteins Induce Alternative Exon Skipping through Their Activities on the Flanking Constitutive Exons

(2010) J. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Arginine Methylation Controls the Subcellular Localization and Functions of the Oncoprotein Splicing Factor SF2/ASF

(2010) Rahul Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo

(2010) G Merdzhanova et al.   ONCOGENE

The anti-angiogenic isoforms of VEGF in health and disease

(2009) Yan Qiu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

SRp38 Regulates Alternative Splicing and Is Required for Ca2+ Handling in the Embryonic Heart

(2009) Ying Feng et al.   DEVELOPMENTAL CELL

Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones

(2009) X.-Y. Zhong et al.   GENES & DEVELOPMENT

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

(2009) Vânia Gonçalves et al.   HUMAN MOLECULAR GENETICS

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 Mediates Cell Cycle and Cell Death in Neurons

(2009) Sung-Wuk Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms

(2009) Dawid G. Nowak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SR Protein Family Members Display Diverse Activities in the Formation of Nascent and Mature mRNPs In Vivo

(2009) Aparna K. Sapra et al.   MOLECULAR CELL

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

SR Proteins in Vertical Integration of Gene Expression from Transcription to RNA Processing to Translation

(2009) Xiang-Yang Zhong et al.   MOLECULAR CELL

Chromatin Binding of SRp20 and ASF/SF2 and Dissociation from Mitotic Chromosomes Is Modulated by Histone H3 Serine 10 Phosphorylation

(2009) Rebecca J. Loomis et al.   MOLECULAR CELL

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Serine/Arginine Protein-Specific Kinase 2 Promotes Leukemia Cell Proliferation by Phosphorylating Acinus and Regulating Cyclin A1

(2008) S.-W. Jang et al.   CANCER RESEARCH

Functional integration of transcriptional and RNA processing machineries

(2008) Shatakshi Pandit et al.   CURRENT OPINION IN CELL BIOLOGY

Akt2 Regulation of Cdc2-Like Kinases (Clk/Sty), Serine/Arginine-Rich (SR) Protein Phosphorylation, and Insulin-Induced Alternative Splicing of PKCβII Messenger Ribonucleic Acid

(2008) Kun Jiang et al.   ENDOCRINOLOGY

Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

(2008) Jun-ichiro Yomoda et al.   GENES TO CELLS

Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts

(2008) J. R. Sanford et al.   GENOME RESEARCH

Growth Hormone Deficiency and Splicing Fidelity

(2008) Amanda S. Solis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptable Molecular Interactions Guide Phosphorylation of the SR Protein ASF/SF2 by SRPK1

(2008) Jonathan C. Hagopian et al.   JOURNAL OF MOLECULAR BIOLOGY

A Sliding Docking Interaction Is Essential for Sequential and Processive Phosphorylation of an SR Protein by SRPK1

(2008) Jacky Chi Ki Ngo et al.   MOLECULAR CELL

The Splicing Factor SF2/ASF Regulates Translation Initiation by Enhancing Phosphorylation of 4E-BP1

(2008) Gracjan Michlewski et al.   MOLECULAR CELL

A Single SR-like Protein, Npl3, Promotes Pre-mRNA Splicing in Budding Yeast

(2008) Tracy L. Kress et al.   MOLECULAR CELL

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

The splicing factor SC35 has an active role in transcriptional elongation

(2008) Shengrong Lin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

(2008) Rebecca Mathew et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The splicing-factor oncoprotein SF2/ASF activates mTORC1

(2008) R. Karni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The  -catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression

(2008) V. Goncalves et al.   RNA