Article
Oncology
Chunxia Zhang, Yinshuang Chen, Fuchao Li, Man Yang, Fanyi Meng, Yawen Zhang, Weichang Chen, Weipeng Wang
Summary: The study identified SRSF3 as a splicing factor involved in the regulation of B7-H3 expression, impacting the prognosis of CRC patients. High expression of SRSF3 and B7-H3 correlates with poor patient outcomes, suggesting SRSF3 as a potential target for regulating B7-H3 expression and CRC therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cell Biology
Yawen Zhang, Mengmeng Wang, Fanyi Meng, Man Yang, Yinshuang Chen, Xuqin Guo, Weiwei Wang, Yifan Zhu, Yundi Guo, Chunlai Feng, Shen Tian, Hongjian Zhang, Huanqiu Li, Jing Sun, Weipeng Wang
Summary: The high expression of SRSF3 in colorectal cancer (CRC) tissues plays a key role in the proliferation and migration of CRC cells. The novel SRSF3 inhibitor, SFI003, effectively suppresses CRC cell growth through the SRSF3/DHCR24/reactive oxygen species (ROS) pathway.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Yunqi Chao, Yonghui Jiang, Mianling Zhong, Kaiyan Wei, Chenxi Hu, Yifang Qin, Yiming Zuo, Lili Yang, Zheng Shen, Chaochun Zou
Summary: Alternative splicing plays a crucial role in regulating gene expression patterns post-transcriptionally, particularly in adipogenesis. Aberrant expression and alterations in splicing regulators are linked to mutations in obesity-related genes, indicating their potential role in diet-induced obesity and metabolic dysregulation. Research on the splicing machinery's interaction with obesity and metabolic disorders provides insights for potential therapeutic strategies in clinical settings.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Madara Ratnadiwakara, Mohamed N. M. Bahrudeen, Erika Aikio, Piia Takabe, Rebekah M. Engel, Zileena Zahir, Thierry Jarde, Paul J. McMurrick, Helen E. Abud, Minna-Liisa Anko
Summary: This study reveals that Serine-arginine rich splicing factor 3 (SRSF3) plays a crucial role in the processing of miR-17-92 cluster miRNAs in pluripotent and cancer cells. SRSF3 binding to CNNC motifs downstream of Drosha cleavage sites is required for efficient processing of the cluster. The interaction between SRSF3 and miR-17-92 results in changes in RNA structure and an increase in miR-17 and miR-20a levels, promoting self-renewal and contributing to colorectal cancer pathogenesis.
Article
Biochemistry & Molecular Biology
Sosuke Miyasato, Kurumi Iwata, Reika Mura, Shou Nakamura, Keisuke Yanagida, Hideo Shindou, Yosuke Nagata, Masahiro Kawahara, Satoshi Yamaguchi, Junken Aoki, Asuka Inoue, Teruyuki Nagamune, Takao Shimizu, Motonao Nakamura
Summary: GPR43 and GPR41 are G protein-coupled receptors activated by short-chain fatty acids and their expression is enhanced in human blood cells and leukemia cell lines. GPR43 is constitutively active and coupled with G alpha(i) and G alpha(12/13). Enhanced GPR43 expression leads to growth arrest in HL-60 cells through G alpha(12/13), and blocking GPR43 activity impairs cell adhesion. These results suggest that GPR43 is crucial for growth arrest and differentiation of leukocytes.
Article
Biology
Xinhui Zhao, Boris Bartholdy, Yukiya Yamamoto, Erica K. Evans, Meritxell Alberich-Jorda, Philipp B. Staber, Touati Benoukraf, Pu Zhang, Junyan Zhang, Bon Q. Trinh, John D. Crispino, Trang Hoang, Mahmoud A. Bassal, Daniel G. Tenen
Summary: The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, which is crucial for macrophage differentiation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dong Han, Guangming Wu, Rui Chen, Hannes C. A. Drexler, Caitlin M. MacCarthy, Kee-Pyo Kim, Kenjiro Adachi, Daniela Gerovska, Lampros Mavrommatis, Ivan Bedzhov, Marcos J. Arauzo-Bravo, Hans R. Schoeler
Summary: This study reveals the importance of Oct4 linker interface-mediated interactions in maintaining pluripotency. Mutations in the linker disrupt the balanced Oct4 interactome, leading to impaired epigenetic state and self-renewal ability of embryonic stem cells. Restoring the expression levels of related factors can rescue the pluripotency of linker mutant ESCs.
Article
Biochemistry & Molecular Biology
Hang Yang, Yunlong Wang, Yunlu Tian, Xuan Teng, Zehui Lv, Jie Lei, Erchao Duan, Hui Dong, Xue Yang, Yuanyan Zhang, Yinglun Sun, Xiaoli Chen, Xiuhao Bao, Rongbo Chen, Chuanwei Gu, Yipeng Zhang, Xiaokang Jiang, Wenyu Ma, Pengcheng Zhang, Yi Ji, Yu Zhang, Yihua Wang, Jianmin Wan
Summary: A mutant rice flo22 showed delayed amyloplast development in endosperm cells, affecting mitochondrial morphology and function. Flo22, encoding a mitochondrion-localized P-type PPR protein, mutations led to defective trans-splicing of mitochondrial nad1 intron 1 and affected complex I assembly and activity. Additionally, FLO22 interacted with DYW3 and participated in mitochondrial RNA editing.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2023)
Article
Engineering, Biomedical
Kihak Gwon, Daheui Choi, Jose M. de Hoyos-Vega, Harihara Baskaran, Alan M. Gonzalez-Suarez, Seonhwa Lee, Hye Jin Hong, Kianna M. Nguyen, Ether Dharmesh, Go Sugahara, Yuji Ishida, Takeshi Saito, Gulnaz Stybayeva, Alexander Revzin
Summary: This paper describes the use of bioactive heparin-based core-shell microcapsules to form and cultivate hepatocyte spheroids. These microcapsules retain and release endogenous signals, enhancing the function of encapsulated hepatocytes. Loading exogenous hepatocyte growth factor (HGF) into microcapsules and inhibiting transforming growth factor (TGF)-β1 signaling further enhances hepatic function.
BIOACTIVE MATERIALS
(2023)
Article
Respiratory System
Sang-Hun Kim, Jung Yeon Lee, Chang Min Yoon, Hyeon Jun Shin, Sei Won Lee, Ivan Rosas, Erica Herzog, Charles S. Dela Cruz, Naftali Kaminski, Min-Jong Kang
Summary: Mitochondrial antiviral signaling protein (MAVS) plays a crucial role in the pathogenesis of pulmonary fibrosis, and targeting MAVS with BH3 mimetics may offer a novel therapeutic strategy. Therapeutic effects of nintedanib and pirfenidone, approved drugs for IPF treatment, are not related to modulation of MAVS or its signaling pathways.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Medicine, Research & Experimental
Arjan F. Theil, Alex Pines, Tugba Kalayci, Jose M. Heredia-Genestar, Anja Raams, Marion H. Rietveld, Sriram Sridharan, Sabine E. J. Tanis, Klaas W. Mulder, Nesimi Bueyuekbabani, Birsen Karaman, Zehra O. Uyguner, Huelya Kayserili, Jan H. J. Hoeijmakers, Hannes Lans, Jeroen A. A. Demmers, Joris Pothof, Umut Altunoglu, Abdoelwaheb El Ghalbzouri, Wim Vermeulen
Summary: This study identifies MPLKIP/TTDN1 gene mutations associated with brittle hair syndrome, which leads to reduced levels of mutant proteins. The study demonstrates the interaction between MPLKIP and core splicing factors as well as DBR1, and highlights the role of MPLKIP in keratinocyte differentiation and the immune system.
EMBO MOLECULAR MEDICINE
(2023)
Article
Oncology
Shih-Han Hsu, Wen-Chun Hung
Summary: Protein methylation plays a crucial role in cellular homeostasis and cancer development. This review focuses on the role of PRMT3, a member of the PRMT family, in regulating oncogenic processes and summarizes its effects on the methylation of regulatory proteins involved in transcription, post-transcriptional control, ribosomal maturation, translation, biological synthesis, and metabolic signaling. The latest progress in the development of PRMT3 inhibitors is also introduced.
Article
Cell Biology
Randa Belgacemi, Zania Diabasana, Antony Hoarau, Xavier Dubernard, Jean-Claude Merol, Christophe Ruaux, Myriam Polette, Jeanne-Marie Perotin, Gaetan Deslee, Valerian Dormoy
Summary: The removal of primary cilia affects the differentiation of respiratory epithelial cells, leading to changes in the composition of the epithelium. Further investigation is needed to understand the pathophysiological implications of primary cilia in respiratory diseases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Ji Park, Hae-Myeong Jung, Areum Lee, Seung-Hee Jo, Hyo-Jun Lee, Hyun-Soon Kim, Choon-Kyun Jung, Sung-Ran Min, Hye-Sun Cho
Summary: OsFKBP20-1b is SUMOylated under stress conditions in rice, leading to enhanced protein stability and interaction with OsSUMO1 and OsSUMO2. The low SUMOylation level of 5KR_OsFKBP20-1b results in inadequate association with U snRNAs in response to heat stress, affecting RNA processing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ryota Kasahara, Tomohisa Yuzawa, Takehsi Fujii, Fugaku Aoki, Masataka G. Suzuki
Summary: DMRT is a highly conserved transcription factor family involved in sex determination, with the dmrt11E gene playing a crucial role in oogenesis in the silkmoth Bombyx mori. Knockout of dmrt11E results in defective ovarian development and production of abnormal eggs with reduced fertility and lipid levels. Transcriptomic analysis identified six genes potentially controlled by dmrt11E, providing insight into lipid uptake and storage in Bombyx mori eggs.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Srirupa Das, Supriya Sen, Anirban Chakraborty, Papia Chakraborti, Mrinal K. Maiti, Asitava Basu, Debabrata Basu, Soumitra K. Sen
Article
Gastroenterology & Hepatology
Supriya Sen, Magda Langiewicz, Hassan Jumaa, Nicholas J. G. Webster
Article
Biochemistry & Molecular Biology
Supriya Sen, Indrani Talukdar, Ying Liu, Joseph Tam, Sita Reddy, Nicholas J. G. Webster
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Supriya Sen, Indrani Talukdar, Nicholas J. G. Webster
MOLECULAR AND CELLULAR BIOLOGY
(2009)
Article
Multidisciplinary Sciences
Indrani Talukdar, Supriya Sen, Rodolfo Urbano, James Thompson, John R. Yates, Nicholas J. G. Webster
Meeting Abstract
Biochemistry & Molecular Biology
Supriya Sen, Nicholas J. G. Webster
Meeting Abstract
Biochemistry & Molecular Biology
Magda Langiewicz, Supriya Sen, Nicholas J. Webster
Article
Agronomy
Munshi Azad Hossain, Mrinal K. Maiti, Asitava Basu, Supriya Sen, Arnab K. Ghosh, Soumitra K. Sen
Meeting Abstract
Biochemistry & Molecular Biology
Indrani Talukdar, Supriya Sen, Nicholas Webster
Meeting Abstract
Biochemistry & Molecular Biology
Indrani Talukdar, Supriya Sen, Nicholas J. G. Webster
Meeting Abstract
Biochemistry & Molecular Biology
Supriya Sen, Indrani Talukdar, Nicholas J. G. Webster