标题
The significance of acid/base properties in drug discovery
作者
关键词
-
出版物
CHEMICAL SOCIETY REVIEWS
Volume 42, Issue 2, Pages 485-496
出版商
Royal Society of Chemistry (RSC)
发表日期
2012-10-25
DOI
10.1039/c2cs35348b
参考文献
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- (2012) Russell T. Naven et al. TOXICOLOGICAL SCIENCES
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- (2011) Fabio Broccatelli et al. ADVANCED DRUG DELIVERY REVIEWS
- Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety
- (2011) Nicholas A. Meanwell CHEMICAL RESEARCH IN TOXICOLOGY
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- (2011) Fengling Zhang et al. DRUG DISCOVERY TODAY
- A Novel Approach for Predicting P-Glycoprotein (ABCB1) Inhibition Using Molecular Interaction Fields
- (2011) Fabio Broccatelli et al. JOURNAL OF MEDICINAL CHEMISTRY
- The influence of the 'organizational factor' on compound quality in drug discovery
- (2011) Paul D. Leeson et al. NATURE REVIEWS DRUG DISCOVERY
- Probing the links between in vitro potency, ADMET and physicochemical parameters
- (2011) M. Paul Gleeson et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular obesity, potency and other addictions in drug discovery
- (2011) Michael M. Hann MedChemComm
- Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
- (2010) Travis T. Wager et al. ACS Chemical Neuroscience
- Phospholipidosis as a Function of Basicity, Lipophilicity, and Volume of Distribution of Compounds
- (2010) Umesh M. Hanumegowda et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Development of Specific “Drug-Like Property” Rules for Carboxylate-Containing Oral Drug Candidates
- (2010) Alexander Böcker et al. ChemMedChem
- Insights for Predicting Blood-Brain Barrier Penetration of CNS Targeted Molecules Using QSPR Approaches
- (2010) Yi Fan et al. Journal of Chemical Information and Modeling
- Evaluation of pKaEstimation Methods on 211 Druglike Compounds
- (2010) John Manchester et al. Journal of Chemical Information and Modeling
- An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs
- (2010) Emanuele Perola JOURNAL OF MEDICINAL CHEMISTRY
- A Medicinal Chemist’s Guide to Molecular Interactions
- (2010) Caterina Bissantz et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2010) Paul D. Leeson et al. MedChemComm
- Using the Golden Triangle to optimize clearance and oral absorption
- (2009) Ted W. Johnson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds
- (2009) Jens-Uwe Peters et al. ChemMedChem
- hERG-related drug toxicity and models for predicting hERG liability and QT prolongation
- (2009) Emanuel Raschi et al. Expert Opinion on Drug Metabolism & Toxicology
- Predicting pKa
- (2009) Adam C. Lee et al. Journal of Chemical Information and Modeling
- Let’s not forget tautomers
- (2009) Yvonne Connolly Martin JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay
- (2009) Leslie Z. Benet MOLECULAR PHARMACEUTICS
- The acid–base profile of a contemporary set of drugs: implications for drug discovery
- (2009) D.T. Manallack SAR AND QSAR IN ENVIRONMENTAL RESEARCH
- Physiochemical drug properties associated with in vivo toxicological outcomes
- (2008) Jason D. Hughes et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Metabolic activation of carboxylic acids
- (2008) Christian Skonberg et al. Expert Opinion on Drug Metabolism & Toxicology
- Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
- (2008) M. Paul Gleeson JOURNAL OF MEDICINAL CHEMISTRY
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