hERG-related drug toxicity and models for predicting hERG liability and QT prolongation
出版年份 2009 全文链接
标题
hERG-related drug toxicity and models for predicting hERG liability and QT prolongation
作者
关键词
-
出版物
Expert Opinion on Drug Metabolism & Toxicology
Volume 5, Issue 9, Pages 1005-1021
出版商
Informa Healthcare
发表日期
2009-07-03
DOI
10.1517/17425250903055070
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Similarity-Based Classifier Using Topomers to Provide a Knowledge Base for hERG Channel Inhibition
- (2009) Britta Nisius et al. Journal of Chemical Information and Modeling
- Support vector machines classification of hERG liabilities based on atom types
- (2008) Lei Jia et al. BIOORGANIC & MEDICINAL CHEMISTRY
- A binary QSAR model for classification of hERG potassium channel blockers
- (2008) Khac-Minh Thai et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Quantitative structure–activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities
- (2008) Scot Mente et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Moving towards better predictors of drug-induced torsades de pointes
- (2008) A S Bass et al. BRITISH JOURNAL OF PHARMACOLOGY
- In vitromodels of proarrhythmia
- (2008) C L Lawrence et al. BRITISH JOURNAL OF PHARMACOLOGY
- International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes
- (2008) A S Bass et al. BRITISH JOURNAL OF PHARMACOLOGY
- Classification Models for hERG Inhibitors by Counter-Propagation Neural Networks
- (2008) Khac-Minh Thai et al. Chemical Biology & Drug Design
- Combining Cluster Analysis, Feature Selection and Multiple Support Vector Machine Models for the Identification of Human Ether-a-go-go Related Gene Channel Blocking Compounds
- (2008) Britta Nisius et al. Chemical Biology & Drug Design
- Shape Signatures: New Descriptors for Predicting Cardiotoxicity In Silico
- (2008) Dmitriy S. Chekmarev et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Modeling hERG and its Interactions with Drugs: Recent Advances in Light of Current Potassium Channel Simulations
- (2008) Maurizio Recanatini et al. ChemMedChem
- GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: The case of hERG K+ channel blockers
- (2008) Giuseppe Ermondi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties
- (2008) Sebastian Polak et al. JOURNAL OF APPLIED TOXICOLOGY
- Computational Models of the Heart and Their Use in Assessing the Actions of Drugs
- (2008) Denis Noble JOURNAL OF PHARMACOLOGICAL SCIENCES
- hERG Classification Model Based on a Combination of Support Vector Machine Method and GRIND Descriptors
- (2008) Qiyuan Li et al. MOLECULAR PHARMACEUTICS
- The hERG K+ channel: target and antitarget strategies in drug development
- (2008) Emanuel Raschi et al. PHARMACOLOGICAL RESEARCH
- Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
- (2008) Gary A. Gintant PHARMACOLOGY & THERAPEUTICS
- Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: A database review and analysis
- (2008) B.M. Dumotier et al. PHARMACOLOGY & THERAPEUTICS
- The hERG potassium channel and hERG screening for drug-induced torsades de pointes
- (2008) Jules C. Hancox et al. PHARMACOLOGY & THERAPEUTICS
- Use of the rabbit with a failing heart to test for torsadogenicity
- (2008) Robert L. Hamlin et al. PHARMACOLOGY & THERAPEUTICS
- Computer-aided prediction of QT-prolongation1
- (2008) O. Filz et al. SAR AND QSAR IN ENVIRONMENTAL RESEARCH
- Drug induced shortening of the QT/QTc interval: An emerging safety issue warranting further modelling and evaluation in drug research and development?
- (2008) Mark Holbrook et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome
- (2007) H Takemasa et al. BRITISH JOURNAL OF PHARMACOLOGY
- Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?
- (2007) M A G Heyden et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Composite Model for hERG Blockade
- (2007) Christian Kramer et al. ChemMedChem
- Exploring QSTR and toxicophore of hERG K+ channel blockers using GFA and HypoGen techniques
- (2007) Divita Garg et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model
- (2007) Jill V. Steidl-Nichols et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: Beyond QT prolongation
- (2007) Hua Rong Lu et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation