Impact of ion class and time on oral drug molecular properties

Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)

(2010) Tony W. J. Cooper et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

(2010) Nigel Greene et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

(2010) Alan P. Hill et al.   DRUG DISCOVERY TODAY

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

(2010) Emanuele Perola   JOURNAL OF MEDICINAL CHEMISTRY

Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination

(2010) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cheminformatic Tools for Medicinal Chemists

(2010) Steven W. Muchmore et al.   JOURNAL OF MEDICINAL CHEMISTRY

The β-d-Glucose Scaffold as a β-Turn Mimetic

(2009) Ralph F. Hirschmann et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Physicochemical property profiles of marketed drugs, clinical candidates and bioactive compounds

(2009) Christian Tyrchan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Using the Golden Triangle to optimize clearance and oral absorption

(2009) Ted W. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability

(2009) Michael J. Waring   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

(2009) Jens-Uwe Peters et al.   ChemMedChem

In Silico hERG Modeling: Challenges and Progress

(2009) David Diller   Current Computer-Aided Drug Design

Medicinal Chemistry Strategies to Minimize Phospholipidosis

(2009) Andrew Ratcliffe   CURRENT MEDICINAL CHEMISTRY

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Physicochemical drug properties associated within vivotoxicological outcomes: a review

(2009) David A Price et al.   Expert Opinion on Drug Metabolism & Toxicology

New Developments in Hydrogen Bonding Acidity and Basicity of Small Organic Molecules for the Prediction of Physical and ADMET Properties. Part 2. The Universal Solvation Equation

(2009) Polina V. Oliferenko et al.   Journal of Chemical Information and Modeling

Do Biologically Relevant Compounds Have More Chance To Be Drugs?

(2009) De-Xin Kong et al.   Journal of Chemical Information and Modeling

In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set

(2009) Giuliano Berellini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Physicochemical Determinants of Human Renal Clearance

(2009) Manthena V. S. Varma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

The influence of lead discovery strategies on the properties of drug candidates

(2009) György M. Keserü et al.   NATURE REVIEWS DRUG DISCOVERY

The acid–base profile of a contemporary set of drugs: implications for drug discovery

(2009) D.T. Manallack   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Straightforward Recursive Partitioning Model for Discarding Insoluble Compounds in the Drug Discovery Process

(2008) Claudia Lamanna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Safety and secondary pharmacology: Successes, threats, challenges and opportunities

(2008) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS