The transcription factor p53: Not a repressor, solely an activator

A New p53 Target Gene, RKIP, Is Essential for DNA Damage-Induced Cellular Senescence and Suppression of ERK Activation

(2015) Su-Jin Lee et al.   NEOPLASIA

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

The CHR site: definition and genome-wide identification of a cell cycle transcriptional element

(2014) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation

(2014) S. Rashi-Elkeles et al.   Science Signaling

Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage

(2014) Y-C Lin et al.   Cell Death & Disease

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

(2014) Mary Ann Allen et al.   eLife

Identification of human guanylate-binding protein 1 gene (hGBP1) as a direct transcriptional target gene of p53

(2013) Zixiang Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rap2b, a novel p53 target, regulates p53-mediated pro-survival function

(2013) Xinyue Zhang et al.   CELL CYCLE

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis

(2013) M Kracikova et al.   CELL DEATH AND DIFFERENTIATION

p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53–E2F1–DNA complex

(2013) Zhe Zhou et al.   EXPERIMENTAL CELL RESEARCH

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

On the Immortality of Television Sets: "Function" in the Human Genome According to the Evolution-Free Gospel of ENCODE

(2013) D. Graur et al.   Genome Biology and Evolution

Local Depletion of DNA Methylation Identifies a Repressive p53 Regulatory Region in theNEK2Promoter

(2013) Nancy H. Nabilsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

(2013) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

(2013) Daniel Menendez et al.   NUCLEIC ACIDS RESEARCH

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

(2013) E K Benson et al.   ONCOGENE

p53 and Cell Cycle Dependent Transcription of kinesin family member 23 (KIF23) Is Controlled Via a CHR Promoter Element Bound by DREAM and MMB Complexes

(2013) Martin Fischer et al.   PLoS One

Wild Type p53 Transcriptionally Represses the SALL2 Transcription Factor under Genotoxic Stress

(2013) Carlos Farkas et al.   PLoS One

GFI1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis

(2013) Pei Du et al.   PLoS One

P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

(2013) Ivan Raimondi et al.   PLoS One

Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality

(2013) Seong-Jun Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1

(2013) Bei Wang et al.   Nature Communications

Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

(2013) Katharina Schlereth et al.   PLoS Genetics

Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment

(2012) Sandeep Singh et al.   BMC MOLECULAR BIOLOGY

Distinct p53 genomic binding patterns in normal and cancer-derived human cells

(2012) Krassimira Botcheva et al.   CELL CYCLE

Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53

(2012) Nathalia Meireles da Costa et al.   CELL CYCLE

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

Interchanging heads

(2012) Matthias Dobbelstein   CELL CYCLE

Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

(2012) F Nikulenkov et al.   CELL DEATH AND DIFFERENTIATION

Expression of the class II tumor suppressor geneRIG1is directly regulated by p53 tumor suppressor in cancer cell lines

(2012) Tzu-Hui Hsu et al.   FEBS LETTERS

DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins

(2012) Sujan Piya et al.   FEBS LETTERS

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

(2012) S. Sadasivam et al.   GENES & DEVELOPMENT

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

(2012) X. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells

(2012) Mingzhen Yang et al.   Molecular Cancer

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

(2012) Orit Rozenblatt-Rosen et al.   NATURE

p53-mediated heterochromatin reorganization regulates its cell fate decisions

(2012) Sathish Kumar Mungamuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The UCSC Genome Browser database: extensions and updates 2013

(2012) Laurence R. Meyer et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2013

(2012) Paul Flicek et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribosyl)ation of p53 induces gene-specific transcriptional repression of MTA1

(2012) M-H Lee et al.   ONCOGENE

p53 Dimers Associate with a Head-to-Tail Response Element to Repress Cyclin B Transcription

(2012) Robert Lipski et al.   PLoS One

A p53-Pax2 Pathway in Kidney Development: Implications for Nephrogenesis

(2012) Zubaida Saifudeen et al.   PLoS One

p53 Acts as a Co-Repressor to Regulate Keratin 14 Expression during Epidermal Cell Differentiation

(2012) Bi-He Cai et al.   PLoS One

p53 Inactivation Upregulates p73 Expression through E2F-1 Mediated Transcription

(2012) Chaitali Tophkhane et al.   PLoS One

PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage

(2012) B H Huang et al.   Cell Death & Disease

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

The nuclear exporter, Crm1, is regulated by NFY and Sp1 in cancer cells and repressed by p53 in response to DNA damage

(2011) Pauline J. van der Watt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

P53 suppresses expression of the 14-3-3gamma oncogene

(2011) Vijayababu M Radhakrishnan et al.   BMC CANCER

Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

(2011) Juan-Manuel Schvartzman et al.   CANCER CELL

p53 Binds to and Is Required for the Repression of Arf Tumor Suppressor by HDAC and Polycomb

(2011) Y. Zeng et al.   CANCER RESEARCH

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH

The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor

(2011) Levin Böhlig et al.   CELL CYCLE

The p53 response element and transcriptional repression

(2011) Bei Wang et al.   CELL CYCLE

The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene

(2011) Sindy Sohr et al.   CELL CYCLE

Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

(2011) V Graupner et al.   CELL DEATH AND DIFFERENTIATION

p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death

(2011) Xi Feng et al.   EMBO JOURNAL

One Function—Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor

(2011) Levin Böhlig et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Disruption of repressive p130-DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells

(2011) N. Nor Rashid et al.   JOURNAL OF GENERAL VIROLOGY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

(2011) Sharon Rashi-Elkeles et al.   Molecular Oncology

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

Reciprocal repression between P53 and TCTP

(2011) Robert Amson et al.   NATURE MEDICINE

Specific inhibition of NF-Y subunits triggers different cell proliferation defects

(2011) Paolo Benatti et al.   NUCLEIC ACIDS RESEARCH

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

(2011) Bart Westendorp et al.   NUCLEIC ACIDS RESEARCH

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

(2011) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors

(2011) M Dalvai et al.   ONCOGENE

Role of p53 Serine 46 in p53 Target Gene Regulation

(2011) Leonie Smeenk et al.   PLoS One

Tumor Suppressor Protein p53 Recruits Human Sin3B/HDAC1 Complex for Down-Regulation of Its Target Promoters in Response to Genotoxic Stress

(2011) Nidhi Bansal et al.   PLoS One

Wild-type p53 controls cell motility and invasion by dual regulation of MET expression

(2011) C.-I. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative results are disappearing from most disciplines and countries

(2011) Daniele Fanelli   SCIENTOMETRICS

p53 Directly Represses Id2 to Inhibit the Proliferation of Neural Progenitor Cells

(2011) Brenton R. Paolella et al.   STEM CELLS

To repress or not to repress: This is the guardian's question

(2011) John L. Rinn et al.   TRENDS IN CELL BIOLOGY

The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks

(2011) Daniel Menendez et al.   PLoS Genetics

Mitofusin-2 is a novel direct target of p53

(2010) Weilin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of p53-mediated repression of the human polycystic kidney disease-1 promoter

(2010) Diederik van Bodegom et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer

(2010) R.-K. Lin et al.   CANCER RESEARCH

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

The retinal dehydrogenase/reductaseretSDR1/DHRS3gene is activated by p53 and p63 but not by mutants derived from tumors or EEC/ADULT malformation syndromes

(2010) Ralf D. Kirschner et al.   CELL CYCLE

p53-dependent repression of polo-like kinase-1 (PLK1)

(2010) Lynsey McKenzie et al.   CELL CYCLE

D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage

(2010) Takuya Kudoh et al.   EXPERIMENTAL CELL RESEARCH

MAP/ERK Kinase Kinase 1 (MEKK1) Mediates Transcriptional Repression by Interacting with Polycystic Kidney Disease-1 (PKD1) Promoter-bound p53 Tumor Suppressor Protein

(2010) M. Rafiq Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Factor κB- and Specificity Protein 1-dependent p53-mediated Bi-directional Regulation of the Human Manganese Superoxide Dismutase Gene

(2010) Sanjit K. Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tackling the widespread and critical impact of batch effects in high-throughput data

(2010) Jeffrey T. Leek et al.   NATURE REVIEWS GENETICS

p53 activates the PANK1/ miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

(2010) Levin Böhlig et al.   NUCLEIC ACIDS RESEARCH

MEF/ELF4 transactivation by E2F1 is inhibited by p53

(2010) Manabu Taura et al.   NUCLEIC ACIDS RESEARCH

The Coordinated P53 and Estrogen Receptor Cis-Regulation at an FLT1 Promoter SNP Is Specific to Genotoxic Stress and Estrogenic Compound

(2010) Yari Ciribilli et al.   PLoS One

Variation in Transcription Factor Binding Among Humans

(2010) M. Kasowski et al.   SCIENCE

Transcriptional Regulation by P53

(2010) R. Beckerman et al.   Cold Spring Harbor Perspectives in Biology

Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

(2009) Tobias Schilling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel p53 target gene,S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway

(2009) Chunsun Li et al.   BIOCHEMICAL JOURNAL

The G Protein-Coupled Receptor 87 Is Necessary for p53-Dependent Cell Survival in Response to Genotoxic Stress

(2009) Y. Zhang et al.   CANCER RESEARCH

Transcriptional Regulation of Estrogen Receptor-  by p53 in Human Breast Cancer Cells

(2009) S. H. Shirley et al.   CANCER RESEARCH

Transcriptional Repression of Epithelial Cell Adhesion Molecule Contributes to p53 Control of Breast Cancer Invasion

(2009) N. V. Sankpal et al.   CANCER RESEARCH

B-MYB Is Required for Recovery from the DNA Damage-Induced G2 Checkpoint in p53 Mutant Cells

(2009) M. Mannefeld et al.   CANCER RESEARCH

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

The regulation of the endosomal compartment byp53the tumor suppressor gene

(2009) Xin Yu et al.   FEBS Journal

The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription

(2009) Gerd A. Müller et al.   FEBS Journal

RETRACTED: GAMT, a p53-Inducible Modulator of Apoptosis, Is Critical for the Adaptive Response to Nutrient Stress

(2009) Takao Ide et al.   MOLECULAR CELL

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

(2009) Harukazu Suzuki et al.   NATURE GENETICS

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

(2009) Taraswi Banerjee et al.   NUCLEIC ACIDS RESEARCH

XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway

(2009) C Tanikawa et al.   ONCOGENE

Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation

(2009) X Montano   ONCOGENE

Pro-proliferative FoxM1 is a target of p53-mediated repression

(2009) A M Barsotti et al.   ONCOGENE

DNA methylation inhibits p53-mediated survivin repression

(2009) N H Nabilsi et al.   ONCOGENE

Redefining the p53 response element

(2009) B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ets-2 and p53 mediate cAMP-induced MMP-2 expression, activity and trophoblast invasion

(2009) Elsebeth Staun-Ram et al.   Reproductive Biology and Endocrinology

Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage

(2008) Wang-Ju Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a p53-response element in the promoter of the proline oxidase gene

(2008) Steve A. Maxwell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 induces distinct epigenetic states at its direct target promoters

(2008) Lukas Vrba et al.   BMC GENOMICS

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

p53-Mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y

(2008) Maria Concetta Faniello et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Estrogen Receptor (ER) β or p53 Attenuates ERα-mediated Transcriptional Activation on theBRCA2Promoter

(2008) Wei Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syntaxin 6, a Regulator of the Protein Trafficking Machinery and a Target of the p53 Family, Is Required for Cell Adhesion and Survival

(2008) Yanhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer

(2008) A. Astanehe et al.   JOURNAL OF CELL SCIENCE

LIM and SH3 protein 1 (Lasp1) is a novel p53 transcriptional target involved in hepatocellular carcinoma

(2008) Bei Wang et al.   JOURNAL OF HEPATOLOGY

Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina

(2008) Deborah M. Wallace et al.   JOURNAL OF NEUROSCIENCE RESEARCH

p53-Targeted LSD1 Functions in Repression of Chromatin Structure and Transcription In Vivo

(2008) W.-W. Tsai et al.   MOLECULAR AND CELLULAR BIOLOGY

Upregulation of Annexin A1 Expression by Butyrate in Human Colon Adenocarcinoma Cells: Role of p53, NF-Y, and p38 Mitogen-Activated Protein Kinase

(2008) E. Lecona et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines

(2008) M. Taura et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression of an IFN-Inducible Cellular Senescence Gene, IFI16, Is Up-Regulated by p53

(2008) L. L. Song et al.   MOLECULAR CANCER RESEARCH

DUSP1 Is Controlled by p53 during the Cellular Response to Oxidative Stress

(2008) Y.-X. Liu et al.   MOLECULAR CANCER RESEARCH

Identification and Functional Characterization of the Human Glutathione S-Transferase P1 Gene as a Novel Transcriptional Target of the p53 Tumor Suppressor Gene

(2008) H.-W. Lo et al.   MOLECULAR CANCER RESEARCH

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of genome-wide p53-binding sites upon stress response

(2008) Leonie Smeenk et al.   NUCLEIC ACIDS RESEARCH

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

(2008) Matteo Rossi et al.   NUCLEIC ACIDS RESEARCH

The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response

(2008) Max Koeppel et al.   NUCLEIC ACIDS RESEARCH

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

(2008) Peter M. Wilson et al.   NUCLEIC ACIDS RESEARCH

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

(2008) A. Zaky et al.   NUCLEIC ACIDS RESEARCH

Rb/E2F4 and Smad2/3 link survivin to TGF-β-induced apoptosis and tumor progression

(2008) J Yang et al.   ONCOGENE

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis

(2008) T Kawase et al.   ONCOGENE

p53 controls hPar1 function and expression

(2008) Z Salah et al.   ONCOGENE

New p53 target, phosphatase of regenerating liver 1 (PRL-1) downregulates p53

(2008) S-H Min et al.   ONCOGENE

p53 regulates FAK expression in human tumor cells

(2007) Vita M. Golubovskaya et al.   MOLECULAR CARCINOGENESIS