Article
Biochemistry & Molecular Biology
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmao Chen, Suet Mien Tan, Siew Cheng Wong
Summary: A large number of neutrophils infiltrate tumors and contribute to the inflammatory tumor microenvironment. The metabolic status of these neutrophils and their role in tumor progression were investigated in a mouse model of pancreatic ductal adenocarcinoma (PDAC). Tumor-infiltrating neutrophils showed enhanced glycolytic activity compared to neutrophils from the bone marrow and blood of the same mouse. Deletion of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in neutrophils reduced tumor burden and improved survival in the mouse model, indicating a potential target for metabolic modulation in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ji Young Kim, Eun Jung Lee, Yuri Ahn, Sujin Park, Yu Jeong Bae, Tae Gyun Kim, Sang Ho Oh
Summary: The study demonstrates that CTSL is a novel target gene of HIF-1 alpha and plays a role in melanosome degradation in melanocytes through lysosomal activity during autophagosome-lysosome fusion. Under autophagy-inducing starvation conditions, the expression of HIF-1 alpha and CTSL is upregulated in melan-a cells. Inhibition of conversion of pro-CTSL to mature CTSL leads to accumulation of certain proteins due to decreased lysosomal activity in the autophagic pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Niya L. Morris, David N. Michael, Kathryn M. Crotty, Sarah S. Chang, Samantha M. Yeligar
Summary: This study investigated the effects of alcohol on the metabolism of alveolar macrophages, revealing that chronic alcohol exposure leads to a shift towards glycolysis in alveolar macrophages, resulting in reduced phagocytic capacity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sara da Silva-Ferreira, Claudio Duarte-Oliveira, Daniela Antunes, Catarina Barbosa-Matos, Ana Mendes-Frias, Egidio Torrado, Sandra Costa, Ricardo Silvestre, Cristina Cunha, Agostinho Carvalho
Summary: Chronic pulmonary aspergillosis is a devastating disease with increasing prevalence worldwide. The characteristic inflammation limits the effectiveness of antifungal therapies. The study shows that hypoxia-inducible factor 1 alpha (HIF-1 alpha) plays a central role in regulating neutrophil function and fungal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biology
Milica Mandic, Kaitlyn Flear, Pearl Qiu, Yihang K. Pan, Steve F. Perry, Kathleen M. Gilmour
Summary: HIF-1α is important for hypoxic survival in zebrafish, particularly in relation to their ability to perform aquatic surface respiration (ASR). When zebrafish are prevented from accessing the surface during severe hypoxia, their survival is significantly compromised. However, when they are allowed to access the surface, there is no difference in survival between wild-type and HIF-1α knockout fish. ASR mitigates the negative effects of HIF-1α loss, with knockouts initiating ASR at a higher oxygen concentration and performing ASR for longer than wild-types.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wenpeng Cao, Shan Lei, Zhirui Zeng, Chaolun Xiao, Baofei Sun, Peng Xie, Yumei Li, Daopeng Luo, Wenfeng Yu
Summary: This study identified TRAA2A as an important hypoxia-associated gene in pancreatic cancer, which is associated with tumor progression and metastasis. TRAA2A is regulated by hypoxia-inducible factor HIF1 alpha and promotes the proliferation and motility of pancreatic cancer cells via activation of the AKT pathway. Therefore, TRAA2A may serve as a novel molecular target for investigating the hypoxic response of pancreatic cancer cells.
Review
Oncology
Liyun Yong, Shasha Tang, Haixin Yu, Hongyi Zhang, Yi Zhang, Yuan Wan, Fengfeng Cai
Summary: Breast cancer is the most common cancer in women, and drug resistance is a persistent clinical challenge. Hypoxia-inducible Factor-1 Alpha (HIF-1α) plays a crucial role in regulating cellular response to hypoxia and is closely associated with multidrug resistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Gulnihal Ozcan
Summary: HIF-1 alpha plays a crucial role in gastric cancer, contributing to stemness and chemoresistance. Despite the lack of complete understanding of its mechanisms in gastric cancer, efforts are being made to identify critical molecular targets and overcome the action of HIF-1 alpha.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi-hui Wang, Dong-yuan Chang, Ming-hui Zhao, Min Chen
Summary: This study revealed that SGLT2i played a renoprotective role in diabetic kidney disease (DKD), at least in part, through alleviating HIF1a/HO1-mediated ferroptosis.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Jin-Woo Kim, Neunghan Jeon, Dong-Eun Shin, So-Young Lee, Myongwhan Kim, Dong Hun Han, Jae Yeon Shin, Soonchul Lee
Summary: The intervertebral disc is a complex joint structure with nucleus pulposus, annulus fibrosus, and cartilaginous endplate. Degeneration of the intervertebral disc involves cellular, compositional, and structural changes, with significant alterations in the extracellular matrix composition with age. The hypoxia-inducible factor HIF-1 alpha is crucial in regulating various processes of intervertebral disc degeneration and may serve as a diagnostic tool and therapeutic target for inhibiting this degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Huixia Liu, Yujuan Li, Jing Xiong
Summary: The kidney maintains a relatively stable level of oxygen partial pressure through a complex interplay of various factors. Hypoxia is a key factor in the pathogenesis of acute kidney injury and chronic kidney disease, as well as in the development of renal cancer.
Review
Oncology
Yuan-rui Xu, An-long Wang, Ya-qing Li
Summary: Patients with chronic obstructive pulmonary disease (COPD) are at a higher risk of developing lung cancer due to chronic persistent inflammation and hypoxia, regardless of their smoking history. The role of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in the crosstalk between inflammation and hypoxia is discussed, as it plays a crucial role in COPD progression to lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
Xuejiao Wei, Yue Hou, Mengtuan Long, Lili Jiang, Yujun Du
Summary: Renal fibrosis is caused by renal tissue damage and repair response disorders, leading to chronic renal failure if not effectively blocked. HIF-1α plays an important role in renal fibrosis and glucose metabolism by regulating the expression of proteins related to aerobic glycolysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Tran Vinh Hong Nguyen, Ulrich Bergmann, Thomas Kietzmann, Daniela Mennerich
Summary: This study found that insulin stimulates the expression of HIF-3 alpha through the PKB signaling pathway under both normal and low oxygen conditions. The phosphorylation site identified in HIF-3 alpha plays a crucial role in its stability and cell migration, highlighting a novel mechanism by which insulin affects HIF-3 alpha expression and activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Rama K. Mishra, Kristine K. Deibler, Matthew R. Clutter, Purav P. Vagadia, Matthew O'Connor, Gary E. Schiltz, Raymond Bergan, Karl A. Scheidt
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2019)
Article
Oncology
Li Xu, Yujie Zhang, Xianmin Xue, Jie Liu, Zeng-Shan Li, Guang-Yu Yang, Ying Song, Yan Pan, Yueyun Ma, Sijun Hu, Aidong Wen, Yanyan Jia, Luz Maria Rodriguez, Mary Beth Tull, Kelly Benante, Seema A. Khan, Ying Cao, Borko Jovanovic, Ellen Richmond, Asad Umar, Raymond Bergan, Kaichun Wu
CANCER PREVENTION RESEARCH
(2020)
Article
Oncology
Limin Zhang, Abhinandan Pattanayak, Wenqi Li, Hyun-Kyung Ko, Graham Fowler, Ryan Gordon, Raymond Bergan
MOLECULAR CANCER THERAPEUTICS
(2020)
Editorial Material
Biochemistry & Molecular Biology
Dane Dickson, Jennifer Johnson, Raymond Bergan, Rebecca Owens, Vivek Subbiah, Razelle Kurzrock
Editorial Material
Biochemistry & Molecular Biology
Dane Dickson, Jennifer Johnson, Raymond Bergan, Rebecca Owens, Vivek Subbiah, Razelle Kurzrock
Article
Oncology
Xiangmei Zhang, Zhenzhen Zhang, Miao Cao, Beichen Liu, Motomi Mori, Shiuh-Wen Luoh, Raymond Bergan, Yueping Liu, Yunjiang Liu
CLINICAL BREAST CANCER
(2020)
Review
Oncology
Allen Li, Raymond C. Bergan
Article
Oncology
Allen Li, Jamie M. Keck, Swapnil Parmar, Janice Patterson, Marilyne Labrie, Allison L. Creason, Brett E. Johnson, Molly Downey, George Thomas, Carol Beadling, Laura M. Heiser, Annette Kolodzie, Alexander R. Guimaraes, Christopher L. Corless, Joe W. Gray, Gordon B. Mills, Raymond C. Bergan, Zahi I. Mitri
Summary: The study describes an integrative approach to understanding the clinical significance of heterogeneity in breast cancer between metastatic lesions using multi-omic analyses of serial biopsies, aiming to improve cancer management. The researchers found remarkable heterogeneity among metastatic lesions in patients with metastatic breast cancer, resulting in discordance in receptor status and genomic alterations and mixed treatment responses.
NPJ PRECISION ONCOLOGY
(2021)
Article
Medicine, General & Internal
Zhen Zhai, Jian Ruan, Yi Zheng, Dong Xiang, Na Li, Jingjing Hu, Jianfei Shen, Yujiao Deng, Jia Yao, Peng Zhao, Shuqian Wang, Si Yang, Linghui Zhou, Ying Wu, Peng Xu, Lijuan Lyu, Jun Lyu, Raymond Bergan, Tianhui Chen, Zhijun Dai
Summary: The incidence and mortality of mesothelioma are continuously increasing worldwide, especially in resource-limited regions with low sociodemographic index levels. Governments and medical institutions should consider formulating optimal policies and strategies for the targeted prevention and management of mesothelioma based on these findings.
Article
Oncology
Marilyne Labrie, Allen Li, Allison Creason, Courtney Betts, Jamie Keck, Brett Johnson, Shamilene Sivagnanam, Christopher Boniface, Hongli Ma, Aurora Blucher, Young Hwan Chang, Koei Chin, Jacqueline Vuky, Alexander R. Guimaraes, Molly Downey, Jeong Youn Lim, Lina Gao, Kiara Siex, Swapnil Parmar, Annette Kolodzie, Paul T. Spellman, Jeremy Goecks, Lisa M. Coussens, Christopher L. Corless, Raymond Bergan, Joe W. Gray, Gordon B. Mills, Zahi I. Mitri
Summary: The study found that stress response to PARP inhibitors in triple negative breast cancer patients can lead to changes in tumor cells and immune cells, affecting treatment outcomes. Therefore, patient-specific combination therapies can be selected based on PARPi-induced emergent changes.
NPJ PRECISION ONCOLOGY
(2021)
Letter
Oncology
Jonathan Q. Trinh, Moataz Ellithi, Nicole Shonka, Raymond C. Bergan
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dimpal M. Kasabwala, Raymond C. Bergan, Kirby P. Gardner, Rena Lapidus, Susan Tsai, Mohammed Aldakkak, Daniel L. Adams
Summary: Micronuclei (MN), fragments of damaged nucleic acids, are a repair mechanism for chromosomal instabilities in cells. Presence of MN in circulating white blood cells indicates increased cancer risk, while their presence in tumor cells indicates aggressive subtypes. MN form independently over time and therapy induction, and are correlated with poor clinical outcomes in colorectal cancer.
Article
Cell Biology
Brett E. Johnson, Allison L. Creason, Jayne M. Stommel, Jamie M. Keck, Swapnil Parmar, Courtney B. Betts, Aurora Blucher, Christopher Boniface, Elmar Bucher, Erik Burlingame, Todd Camp, Koei Chin, Jennifer Eng, Joseph Estabrook, Heidi S. Feiler, Michael B. Heskett, Zhi Hu, Annette Kolodzie, Ben L. Kong, Marilyne Labrie, Jinho Lee, Patrick Leyshock, Souraya Mitri, Janice Patterson, Jessica L. Riesterer, Shamilene Sivagnanam, Julia Somers, Damir Sudar, Guillaume Thibault, Benjamin R. Weeder, Christina Zheng, Xiaolin Nan, Reid F. Thompson, Laura M. Heiser, Paul T. Spellman, George Thomas, Emek Demir, Young Hwan Chang, Lisa M. Coussens, Alexander R. Guimaraes, Christopher Corless, Jeremy Goecks, Raymond Bergan, Zahi Mitri, Gordon B. Mills, Joe W. Gray
Summary: This study presents an omic and multidimensional spatial atlas constructed from four serial biopsies of a patient with metastatic breast cancer. The atlas provides insights into the mechanisms of therapeutic resistance and vulnerability, and identifies potential novel therapeutic vulnerabilities.
CELL REPORTS MEDICINE
(2022)
Article
Oncology
Swapnil Parmar, Jamie M. Keck, Ben Kong, Regan Look, Brett Johnson, Janice Patterson, Marilyne Labrie, Alexander R. Guimaraes, Christopher L. Corless, Carol Beadling, Annette Kolodzie, Raymond Bergan, Joe W. Gray, Gordon B. Mills, Zahi Mitri
JCO PRECISION ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Amin Mansoorifar, Ryan Gordon, Raymond C. Bergan, Luiz E. Bertassoni
Summary: Bone is a dynamic organ capable of adapting to changes in the body and repairing damaged tissue, but diseases like osteoporosis and metastatic cancers can compromise its function. Microfluidic technologies and organ-on-a-chip models provide more realistic tissue culture conditions, allowing for a better understanding of bone biology, diseases, and treatments. These advanced models offer potential for improved research in bone-related fields.
ADVANCED FUNCTIONAL MATERIALS
(2021)