Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells

(2012) C. Nishida et al.   BLOOD

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease

(2011) S. D'Souza et al.   BLOOD

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

(2011) S K Martin et al.   LEUKEMIA

Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug

(2010) J. Hu et al.   BLOOD

Advances in the understanding of myeloma bone disease and tumour growth

(2010) Shmuel Yaccoby   BRITISH JOURNAL OF HAEMATOLOGY

Hypoxia stimulates osteoclast formation from human peripheral blood

(2010) Jennifer C. Utting et al.   CELL BIOCHEMISTRY AND FUNCTION

Targeting the bone microenvironment in multiple myeloma

(2010) G. David Roodman   JOURNAL OF BONE AND MINERAL METABOLISM

HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients

(2010) P Storti et al.   LEUKEMIA

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

(2010) S Colla et al.   LEUKEMIA

Targeting Angiogenesis via a c-Myc/Hypoxia-Inducible Factor-1 -Dependent Pathway in Multiple Myeloma

(2009) J. Zhang et al.   CANCER RESEARCH

Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan

(2009) Y. Hu et al.   MOLECULAR CANCER THERAPEUTICS

Turn me on: regulating HIF transcriptional activity

(2008) K Lisy et al.   CELL DEATH AND DIFFERENTIATION

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma

(2008) Anurag Purushothaman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased bone marrow microvascular density in haematological malignancies is associated with differential regulation of angiogenic factors

(2008) H F S Negaard et al.   LEUKEMIA

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

(2008) Aline Bozec et al.   NATURE

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY

HIF-1 regulation: not so easy come, easy go

(2008) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES