标题
The Akt signaling pathway
作者
关键词
-
出版物
CANCER BIOLOGY & THERAPY
Volume 12, Issue 12, Pages 1032-1049
出版商
Informa UK Limited
发表日期
2012-01-11
DOI
10.4161/cbt.12.12.18442
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- mTOR Signalling in Health and Disease: Figure 1
- (2011) Christopher G. Proud BIOCHEMICAL SOCIETY TRANSACTIONS
- eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206
- (2011) Y. Cheng et al. CANCER RESEARCH
- PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression
- (2011) K. H. T. Paraiso et al. CANCER RESEARCH
- Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors
- (2011) B. L. Falcon et al. CANCER RESEARCH
- The Akt kinases: Isoform specificity in metabolism and cancer
- (2011) Eva Gonzalez et al. CELL CYCLE
- Riluzole Enhances Ionizing Radiation-Induced Cytotoxicity in Human Melanoma Cells that Ectopically Express Metabotropic Glutamate Receptor 1 In Vitro and In Vivo
- (2011) A. J. Khan et al. CLINICAL CANCER RESEARCH
- Mammalian Target of Rapamycin (mTOR) Inhibitors
- (2011) Sofia Sofroniadou et al. DRUG SAFETY
- Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail
- (2010) Gajanan S. Inamdar et al. BIOCHEMICAL PHARMACOLOGY
- Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies
- (2010) Milind M Javle et al. BMC CANCER
- An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
- (2010) Craig Cherrin et al. CANCER BIOLOGY & THERAPY
- Melanoma Chemoprevention in Skin Reconstructs and Mouse Xenografts Using Isoselenocyanate-4
- (2010) N. Nguyen et al. Cancer Prevention Research
- Preclinical Evaluation of Radiation and Perifosine in a Genetically and Histologically Accurate Model of Brainstem Glioma
- (2010) O. J. Becher et al. CANCER RESEARCH
- Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells
- (2010) Y. N. V. Gopal et al. CANCER RESEARCH
- Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells
- (2010) Y. Shao et al. CANCER RESEARCH
- Hexamethylene Bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF-κB activity: Implications for cancer therapy
- (2010) Anwesha Dey et al. CELL CYCLE
- Regulation of Akt signaling activation by ubiquitination
- (2010) Wei-Lei Yang et al. CELL CYCLE
- Vertical Targeting of the Phosphatidylinositol-3 Kinase Pathway as a Strategy for Treating Melanoma
- (2010) S. A. Aziz et al. CLINICAL CANCER RESEARCH
- NVP-BEZ235 as a New Therapeutic Option for Sarcomas
- (2010) M. C. Manara et al. CLINICAL CANCER RESEARCH
- Akt inhibitors in clinical development for the treatment of cancer
- (2010) Sumanta Kumar Pal et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway
- (2010) Sauveur-Michel Maira et al. Future Medicinal Chemistry
- Recent advances in the discovery of small molecule mTOR inhibitors
- (2010) Abhijit Roychowdhury et al. Future Medicinal Chemistry
- A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies
- (2010) Sarah M. Temkin et al. GYNECOLOGIC ONCOLOGY
- Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
- (2010) Christopher R. Garrett et al. INVESTIGATIONAL NEW DRUGS
- A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation
- (2010) Donghwa Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Conditional ablation of Ikkb inhibits melanoma tumor development in mice
- (2010) Jinming Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Phase II Trial of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Relapsed or Refractory Waldenström Macroglobulinemia
- (2010) Irene M. Ghobrial et al. JOURNAL OF CLINICAL ONCOLOGY
- Akt Phosphorylation at Ser473 Predicts Benefit of Paclitaxel Chemotherapy in Node-Positive Breast Cancer
- (2010) Sherry X. Yang et al. JOURNAL OF CLINICAL ONCOLOGY
- Vertical Inhibition of the mTORC1/mTORC2/PI3K Pathway Shows Synergistic Effects against Melanoma In Vitro and In Vivo
- (2010) Johannes Werzowa et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma
- (2010) Helena Pópulo et al. MELANOMA RESEARCH
- Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor
- (2010) Y. Zheng et al. MOLECULAR AND CELLULAR BIOLOGY
- Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor
- (2010) E. J. Meuillet et al. MOLECULAR CANCER THERAPEUTICS
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
- (2010) Cory M. Johannessen et al. NATURE
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- (2010) Ramin Nazarian et al. NATURE
- Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: A phase I study
- (2010) N. Butowski et al. NEURO-ONCOLOGY
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
- (2010) C Nogueira et al. ONCOGENE
- Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program
- (2010) Hernan Carol et al. PEDIATRIC BLOOD & CANCER
- Nanoparticle-mediated targeting of phosphatidylinositol-3-kinase signaling inhibits angiogenesis
- (2009) Rania Harfouche et al. ANGIOGENESIS
- Efficacy of everolimus (RAD001) in patients with advanced NSCLC previously treated with chemotherapy alone or with chemotherapy and EGFR inhibitors
- (2009) J.-C. Soria et al. ANNALS OF ONCOLOGY
- A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1
- (2009) Jingxiang Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se′-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)—against colon cancer
- (2009) Dhimant Desai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys
- (2009) Izet M. Kapetanovic et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT
- (2009) S. A. Moses et al. CANCER RESEARCH
- Phosphatidylinositol-3-Kinase as a Therapeutic Target in Melanoma
- (2009) S. A. Aziz et al. CLINICAL CANCER RESEARCH
- Targeting Akt3 Signaling in Malignant Melanoma Using Isoselenocyanates
- (2009) A. Sharma et al. CLINICAL CANCER RESEARCH
- A Phase 0 Trial of Riluzole in Patients with Resectable Stage III and IV Melanoma
- (2009) D. Yip et al. CLINICAL CANCER RESEARCH
- PI 3-kinase and cancer: changing accents
- (2009) Peter K Vogt et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- The PKB/AKT Pathway in Cancer
- (2009) Amancio Carnero CURRENT PHARMACEUTICAL DESIGN
- Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt
- (2009) Dong Bai et al. INTERNATIONAL JOURNAL OF CANCER
- Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors
- (2009) R. Marone et al. MOLECULAR CANCER RESEARCH
- Akt/Protein Kinase B and Glycogen Synthase Kinase-3 Signaling Pathway Regulates Cell Migration through the NFAT1 Transcription Factor
- (2009) M. Yoeli-Lerner et al. MOLECULAR CANCER RESEARCH
- BrafV600E cooperates with Pten loss to induce metastatic melanoma
- (2009) David Dankort et al. NATURE GENETICS
- AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K
- (2009) J M Askham et al. ONCOGENE
- Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice
- (2009) V K Goel et al. ONCOGENE
- BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma
- (2009) Supriya Gaitonde et al. Pigment Cell & Melanoma Research
- The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma
- (2009) SubbaRao V. Madhunapantula et al. Pigment Cell & Melanoma Research
- The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation
- (2009) W.-L. Yang et al. SCIENCE
- Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2 Phosphorylation Pathway
- (2009) Z. Mounir et al. Science Signaling
- Perifosine: Update on a novel Akt inhibitor
- (2009) Joell J. Gills et al. Current Oncology Reports
- Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
- (2009) Morris E Feldman et al. PLOS BIOLOGY
- A novel AKT3 mutation in melanoma tumours and cell lines
- (2008) M A Davies et al. BRITISH JOURNAL OF CANCER
- Targeting V600EB-Raf and Akt3 Using Nanoliposomal-Small Interfering RNA Inhibits Cutaneous Melanocytic Lesion Development
- (2008) M. A. Tran et al. CANCER RESEARCH
- Is B-Raf a Good Therapeutic Target for Melanoma and Other Malignancies?
- (2008) S. V. Madhunapantula et al. CANCER RESEARCH
- Akt3 and Mutant V600EB-Raf Cooperate to Promote Early Melanoma Development
- (2008) M. Cheung et al. CANCER RESEARCH
- Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
- (2008) N. Rhodes et al. CANCER RESEARCH
- Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
- (2008) Narendra Wajapeyee et al. CELL
- Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Metastatic Melanoma
- (2008) D. B. Solit et al. CLINICAL CANCER RESEARCH
- Combining Nanoliposomal Ceramide with Sorafenib Synergistically Inhibits Melanoma and Breast Cancer Cell Survival to Decrease Tumor Development
- (2008) M. A. Tran et al. CLINICAL CANCER RESEARCH
- Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia
- (2008) M.-C. Crouthamel et al. CLINICAL CANCER RESEARCH
- Combined Inhibition of MAPK and mTOR Signaling Inhibits Growth, Induces Cell Death, and Abrogates Invasive Growth of Melanoma Cells
- (2008) Konstantinos G. Lasithiotakis et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Proliferation Arrest in B-Raf Mutant Melanoma Cell Lines upon MAPK Pathway Activation
- (2008) Roland Houben et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Inhibition of PI3K-AKT-mTOR Signaling Sensitizes Melanoma Cells to Cisplatin and Temozolomide
- (2008) Tobias Sinnberg et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Synthesis and Anticancer Activity Comparison of Phenylalkyl Isoselenocyanates with Corresponding Naturally Occurring and Synthetic Isothiocyanates
- (2008) Arun K. Sharma et al. JOURNAL OF MEDICINAL CHEMISTRY
- PBISe, a novel selenium-containing drug for the treatment of malignant melanoma
- (2008) S. V. Madhunapantula et al. MOLECULAR CANCER THERAPEUTICS
- K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer
- (2008) Christos S. Karapetis et al. NEW ENGLAND JOURNAL OF MEDICINE
- PI3K/Akt: getting it right matters
- (2008) T F Franke ONCOGENE
- The antidepressant sertraline downregulates Akt and has activity against melanoma cells
- (2008) Kalpana K. Reddy et al. Pigment Cell & Melanoma Research
- Expression patterns and predictive value of phosphorylated AKT in early-stage breast cancer
- (2007) F. Andre et al. ANNALS OF ONCOLOGY
- Targeting phosphoinositide 3-kinase—Moving towards therapy
- (2007) Romina Marone et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
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