标题
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
作者
关键词
-
出版物
NATURE
Volume 468, Issue 7326, Pages 968-972
出版商
Springer Nature
发表日期
2010-11-25
DOI
10.1038/nature09627
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inhibition of Tumor Progression Locus 2 Protein Kinase Suppresses Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclastogenesis through Down-Regulation of the c-Fos and Nuclear Factor of Activated T Cells c1 Genes
- (2010) Kazuya Hirata et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
- (2010) Sonja J. Heidorn et al. CELL
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
- (2010) Keith T. Flaherty et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction
- (2009) K. M. Lee et al. CANCER RESEARCH
- Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression
- (2009) K. P. Hoeflich et al. CANCER RESEARCH
- Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer
- (2009) R Seth et al. GUT
- C-Raf Inhibits MAPK Activation and Transformation by B-RafV600E
- (2009) Florian A. Karreth et al. MOLECULAR CELL
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- MEK1 mutations confer resistance to MEK and B-RAF inhibition
- (2009) C. M. Emery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of thieno[2,3-c]pyridines as potent COT inhibitors
- (2008) Dawn George et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
- (2008) J. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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