期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 6, 页码 2038-2043出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.071
关键词
Chemoprevention; iNOS/Akt inhibitor; PBISe; Colon cancer
资金
- NIH [R03 CA1378763]
- NCI [NCI-CB-56603]
- Penn State Cancer Institute
Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents. (C) 2010 Published by Elsevier Ltd.
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