Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease

S-linked protein homocysteinylation: identifying targets based on structural, physicochemical and protein–protein interactions of homocysteinylated proteins

(2013) Yumnam Silla et al.   AMINO ACIDS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Systems Biology Approach Reveals Genome to Phenome Correlation in Type 2 Diabetes

(2013) Priyanka Jain et al.   PLoS One

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

Alzheimer Disease Susceptibility Loci: Evidence for a Protein Network under Natural Selection

(2012) Towfique Raj et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

(2012) James D. Doecke   ARCHIVES OF NEUROLOGY

An unbiased evaluation of gene prioritization tools

(2012) Daniela Börnigen et al.   BIOINFORMATICS

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases

(2012) Volkmar Tell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

clusterMaker: a multi-algorithm clustering plugin for Cytoscape

(2012) John H Morris et al.   BMC BIOINFORMATICS

Beyond differential expression: the quest for causal mutations and effector molecules

(2012) Nicholas J Hudson et al.   BMC GENOMICS

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

(2012) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants

(2012) Kelly Regan et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Quantitative assessment of the effect of ABCA1 gene polymorphism on the risk of Alzheimer’s disease

(2012) Xiao-Feng Wang et al.   MOLECULAR BIOLOGY REPORTS

Computational tools for prioritizing candidate genes: boosting disease gene discovery

(2012) Yves Moreau et al.   NATURE REVIEWS GENETICS

Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons

(2012) Bilal Malik et al.   NEUROCHEMISTRY INTERNATIONAL

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration

(2012) Héctor J. De Jesús-Cortés et al.   NEUROREPORT

Plasma Apolipoprotein Levels Are Associated with Cognitive Status and Decline in a Community Cohort of Older Individuals

(2012) Fei Song et al.   PLoS One

Gene Network and Pathway Analysis of Mice with Conditional Ablation of Dicer in Post-Mitotic Neurons

(2012) Véronique Dorval et al.   PLoS One

Concerted Perturbation Observed in a Hub Network in Alzheimer’s Disease

(2012) Dapeng Liang et al.   PLoS One

Epidermal growth factor receptor is a preferred target for treating Amyloid- -induced memory loss

(2012) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

(2012) Christina M. Lill et al.   PLoS Genetics

Positional integratomic approach in identification of genomic candidate regions for Parkinson's disease

(2011) Ales Maver et al.   BIOINFORMATICS

Network-based methods for human disease gene prediction

(2011) X. Wang et al.   Briefings in Functional Genomics

Normalization of gene expression using SYBR green qPCR: A case for paraoxonase 1 and 2 in Alzheimer's disease brains

(2011) Valérie Leduc et al.   JOURNAL OF NEUROSCIENCE METHODS

Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients

(2011) Zhi-Ping Liu et al.   Molecular BioSystems

Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease

(2011) Xiaolan Hu et al.   PLoS One

Prioritization of Epilepsy Associated Candidate Genes by Convergent Analysis

(2011) Peilin Jia et al.   PLoS One

A New Methodology to Associate SNPs with Human Diseases According to Their Pathway Related Context

(2011) Burcu Bakir-Gungor et al.   PLoS One

Age-related changes in gene expression are accelerated in Alzheimer's disease

(2011) P. Saetre et al.   SYNAPSE

The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease

(2011) Carmen Antúnez et al.   Genome Medicine

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

(2011) Ellen M. Wijsman et al.   PLoS Genetics

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration

(2010) Radosveta Koldamova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Gene prioritization in Type 2 Diabetes using domain interactions and network analysis

(2010) Amitabh Sharma et al.   BMC GENOMICS

Identifying dysfunctional crosstalk of pathways in various regions of Alzheimer's disease brains

(2010) Zhi-Ping Liu et al.   BMC Systems Biology

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

(2010) Lin Teng et al.   CELL RESEARCH

Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability

(2010) Xinkun Wang et al.   CURRENT GENOMICS

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype

(2010) C Conejero-Goldberg et al.   MOLECULAR PSYCHIATRY

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

(2009) Jennifer A. Webster et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Greasing the wheels of Aβ clearance in Alzheimer's Disease: The role of lipids and apolipoprotein E

(2009) Jianjia Fan et al.   BIOFACTORS

SCAN: SNP and copy number annotation

(2009) Eric R. Gamazon et al.   BIOINFORMATICS

A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases–schizophrenia as a case

(2009) Jingchun Sun et al.   BIOINFORMATICS

 -Opioid Receptor Cell Surface Expression Is Regulated by Its Direct Interaction with Ribophorin I

(2009) X. Ge et al.   MOLECULAR PHARMACOLOGY

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Meta-analysis of linkage studies for Alzheimer's disease—A web resource

(2009) Amy W. Butler et al.   NEUROBIOLOGY OF AGING

Layered Functional Network Analysis of Gene Expression in Human Heart Failure

(2009) Wenliang Zhu et al.   PLoS One

GWAS Meets Microarray: Are the Results of Genome-Wide Association Studies and Gene-Expression Profiling Consistent? Prostate Cancer as an Example

(2009) Ivan P. Gorlov et al.   PLoS One

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A computational analysis of protein-protein interaction networks in neurodegenerative diseases

(2008) Joaquín Goñi et al.   BMC Systems Biology

Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology

(2008) Winnie S. Liang et al.   NEUROBIOLOGY OF AGING

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

(2008) Winnie S. Liang et al.   PHYSIOLOGICAL GENOMICS