Concerted Perturbation Observed in a Hub Network in Alzheimer’s Disease

Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

(2014) Wen-Xing Ding et al.   Autophagy

Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients

(2011) Zhi-Ping Liu et al.   Molecular BioSystems

Gene expression profiling of peripheral blood leukocytes identifies and validates ABCB1 as a novel biomarker for Alzheimer's disease

(2011) Kuang-Den Chen et al.   NEUROBIOLOGY OF DISEASE

Cytoplasmic dynein in neurodegeneration

(2011) Judith Eschbach et al.   PHARMACOLOGY & THERAPEUTICS

Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration

(2011) C. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression

(2010) Pascale Fehlbaum-Beurdeley et al.   Alzheimers & Dementia

BioNet: an R-Package for the functional analysis of biological networks

(2010) D. Beisser et al.   BIOINFORMATICS

WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit

(2010) Dexter Duncan et al.   BMC BIOINFORMATICS

Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks

(2010) Monika Ray et al.   BMC Systems Biology

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Diseases as network perturbations

(2010) Antonio del Sol et al.   CURRENT OPINION IN BIOTECHNOLOGY

Loss of Function ofATXN1Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

(2010) K N Manolopoulos et al.   MOLECULAR PSYCHIATRY

Spatial Memory Consolidation is Associated with Induction of Several Lysine-Acetyltransferase (Histone Acetyltransferase) Expression Levels and H2B/H4 Acetylation-Dependent Transcriptional Events in the Rat Hippocampus

(2010) Olivier Bousiges et al.   NEUROPSYCHOPHARMACOLOGY

Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation

(2010) Juan Nunez-Iglesias et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Amyloid and Alzheimer’s disease

(2010) Hongxing Lei   Protein & Cell

Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

(2009) Jennifer A. Webster et al.   AMERICAN JOURNAL OF HUMAN GENETICS

KEA: kinase enrichment analysis

(2009) A. Lachmann et al.   BIOINFORMATICS

Genetic Analysis of Alzheimer’s Disease in the Uppsala Longitudinal Study of Adult Men

(2009) Vilmantas Giedraitis et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

(2009) P R Maycox et al.   MOLECULAR PSYCHIATRY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Transcriptome Analysis of Synaptoneurosomes Identifies Neuroplasticity Genes Overexpressed in Incipient Alzheimer's Disease

(2009) Celia Williams et al.   PLoS One

The Human Ageing Genomic Resources: online databases and tools for biogerontologists

(2008) João Pedro de Magalhães et al.   AGING CELL

Association studies of 22 candidate SNPs with late-onset Alzheimer's disease

(2008) Jessica A. Figgins et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Identifying functional modules in protein-protein interaction networks: an integrated exact approach

(2008) M. T. Dittrich et al.   BIOINFORMATICS

14-3-3 Zeta and Tau Genes Interactively Decrease Alzheimer’s Disease Risk

(2008) Ignacio Mateo et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Gene–gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk

(2008) I. Mateo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging

(2008) J. A. Miller et al.   JOURNAL OF NEUROSCIENCE

Persistent ERK activation maintains learning-induced long-lasting modulation of synaptic connectivity

(2008) S. I. Cohen-Matsliah et al.   LEARNING & MEMORY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

(2008) Winnie S. Liang et al.   PHYSIOLOGICAL GENOMICS

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases

(2008) Monika Ray et al.   GENOME BIOLOGY

The microtubule-associated protein tau is phosphorylated by Syk

(2007) Thibaud Lebouvier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Translational gene mapping of cognitive decline

(2006) Beth Wilmot et al.   NEUROBIOLOGY OF AGING

Activation of protein kinase C modulates BACE1-mediated β-secretase activity

(2006) Lizhen Wang et al.   NEUROBIOLOGY OF AGING