Review
Geriatrics & Gerontology
Dibyadeep Datta
Summary: Aging rhesus macaques serve as an invaluable model for studying the etiological mechanisms of sporadic Alzheimer's disease (AD) and exploring novel therapeutic strategies. These macaques naturally exhibit amyloid and tau pathology, synaptic dysfunction, and cognitive impairments similar to human AD. Unique molecular mechanisms in the newly evolved primate dorsolateral prefrontal cortex, involving feedforward cyclic adenosine monophosphate (cAMP)-Protein kinase A (PKA)-calcium signaling, play a critical role in higher-order cognition. However, genetic predispositions and age-related insults can exacerbate these signaling pathways and lead to downstream effects, increasing susceptibility to atrophy.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Christiaan F. M. Huffels, Roland E. van Dijk, Henk Karst, Frank J. Meye, Elly M. Hol, Jinte Middeldorp
Summary: The study demonstrates that blood-borne factors are sufficient to drive neurophysiological impairments in the hippocampal CA1, leading to impaired levels of long-term potentiation (LTP). These impairments are similar to those found in mouse models for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Hiroaki Mori, Yu Funahashi, Yuta Yoshino, Hiroshi Kumon, Yuki Ozaki, Kiyohiro Yamazaki, Shinichiro Ochi, Ayumi Tachibana, Taku Yoshida, Hideaki Shimizu, Takaaki Mori, Jun-ichi Iga, Shu-ichi Ueno
Summary: The study demonstrates a significant correlation between CDKN2A gene expression in blood and age, with decreased levels in AD patients compared to healthy controls. Unlike other neurodegenerative diseases, CDKN2A mRNA expression in blood of AD patients is positively correlated with methylation rates. Further research with larger sample sizes is needed to clarify the relationship between CDKN2A gene expression in blood and the development of other neurodegenerative diseases, but it may be a potential biomarker for differentiating AD from normal aging and other neurodegenerative diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Amaya Urdanoz-Casado, Javier Sanchez-Ruiz de Gordoa, Maitane Robles, Miren Roldan, Maria Victoria Zelaya, Idoia Blanco-Luquin, Maite Mendioroz
Summary: Genetic variants in the TREM2 gene, which is related to microglia, have been found to be risk factors for Alzheimer's disease (AD). This study discovered a new type of non-coding RNA called circular RNAs (circRNAs), which originate from TREM2. A specific circRNA called circTREM2_1 was identified in the entorhinal cortex of both control subjects and AD patients, and the expression level of TREM2 mRNA was found to be elevated in AD patients compared to controls. These findings provide insights into the innate immune response in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Vaclav Trojan, Leos Landa, Alexandra Sulcova, Jiri Sliva, Radovan Hrib
Summary: The use of cannabinoids, particularly THC and CBD, for therapeutic purposes has gained attention. THC has limitations due to its psychotropic effects and potential for dependence. CBD, on the other hand, is highlighted for its therapeutic properties without the risk of dependence.
Review
Biochemistry & Molecular Biology
Eleonora Ficiara, Ilaria Stura, Caterina Guiot
Summary: Alterations in iron homeostasis during aging can lead to increased iron levels and oxidative damage. Abnormal accumulation of iron in the brain has been proposed as a biomarker for neurodegeneration, but there is uncertainty regarding the link between brain iron accumulation and aging and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Mariko Ueno, Yuta Yoshino, Hiroaki Mori, Yu Funahashi, Hiroshi Kumon, Shinichiro Ochi, Tomoki Ozaki, Ayumi Tachibana, Taku Yoshida, Hideaki Shimizu, Takaaki Mori, Jun-ichi Iga, Shu-ichi Ueno
Summary: The expression level of ALDH2 in the blood of LOAD patients was significantly increased, and there was a genetic association with ALDH2*2 in LOAD. ALDH2 may have significant roles in the pathogenesis of LOAD in the Asian population.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Linda K. McEvoy, Steve Horvath, Eric A. Whitsel, Stephen R. Rapp, Mark A. Espeland, Susan M. Resnick, JoAnn E. Manson, Jiu-Chiuan Chen, Brian H. Chen, Wenjun Li, Kathleen M. Hayden, Wei Bao, Cynthia D. J. Kusters, Andrea Z. LaCroix
Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Daniela Baracaldo-Santamaria, Sara Sofia Avendano-Lopez, Daniel Felipe Ariza-Salamanca, Mateo Rodriguez-Giraldo, Carlos A. Calderon-Ospina, Rodrigo E. Gonzalez-Reyes, Mauricio O. Nava-Mesa
Summary: Alzheimer's disease is a chronic neurodegenerative disease that causes progressive dementia in older adults. It is characterized by memory loss and cognitive impairment due to dysfunction in cholinergic pathways and neurotoxicity mediated by N-methyl-D-aspartate (NMDA). The presence of intracellular neurofibrillary tangles, extracellular amyloid-beta (A beta) plaques, and selective neurodegeneration are the pathological hallmarks of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vladimir Sukhorukov, Dmitry Voronkov, Tatiana Baranich, Natalia Mudzhiri, Alina Magnaeva, Sergey Illarioshkin
Summary: Aging is associated with cognitive decline due to accumulated damage to brain cells, with mitophagy playing a crucial role in managing mitochondrial quality and quantity. Mitophagy defects contribute to aging and age-related diseases, highlighting potential therapeutic targets for neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Huiyi Wu, Lei Huang, Shushan Zhang, Yang Zhang, Yajia Lan
Summary: The study aimed to evaluate the associations between daytime napping, biological aging measures, and cognition, and examine whether the effects on cognition were mediated by a more advanced state of aging. It was found that non-nappers showed a more advanced state of aging and faster cognitive decline compared to moderate nappers. The results suggest that moderate napping could promote healthy aging and reduce cognitive decline in middle-aged and older Chinese adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Immunology
Joanna Mackiewicz, Malwina Lisek, Tomasz Boczek
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline. It is associated with beta-amyloid plaques, tau tangles, and a sustained inflammatory response. The CaN/NFAT signaling pathway has been found to contribute to the progression of Alzheimer's disease and targeting this pathway may have therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Article
Biochemistry & Molecular Biology
Holly C. Hunsberger, Sharay E. Setti, Carolyn C. Rudy, Daniel S. Weitzner, Jeremiah C. Pfitzer, Kelli L. McDonald, Hao Hong, Subhrajit Bhattacharya, Vishnu Suppiramaniam, Miranda N. Reed
Summary: This study using a mouse model found that increased expression of P301L Tau in aged mice leads to memory deficits, potentially due to late-stage tau pathology and dysregulation of glutamate release and uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Bjorn Reinius, Martina Blunder, Frances M. Brett, Anders Eriksson, Kalicharan Patra, Jorgen Jonsson, Elena Jazin, Klas Kullander
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2015)
Article
Neurosciences
Bryn Farnsworth, Christiane Peuckert, Bettina Zimmermann, Elena Jazin, Petronella Kettunen, Lina Sors Emilsson
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Multidisciplinary Sciences
Katarzyna J. Radomska, Jonathan Sager, Bryn Farnsworth, Asa Tellgren-Roth, Giulia Tuveri, Christiane Peuckert, Petronella Kettunen, Elena Jazin, Lina S. Emilsson
Article
Endocrinology & Metabolism
Martin M. Johansson, Elin Lundin, Xiaoyan Qian, Mohammadreza Mirzazadeh, Jonatan Halvardson, Elisabeth Darj, Lars Feuk, Mats Nilsson, Elena Jazin
BIOLOGY OF SEX DIFFERENCES
(2016)
Article
Biotechnology & Applied Microbiology
Bjorn Reinius, Chengxi Shi, Liu Hengshuo, Kuljeet Singh Sandhu, Katarzyna J. Radomska, Glenn D. Rosen, Lu Lu, Klas Kullander, Robert W. Williams, Elena Jazin
Article
Biotechnology & Applied Microbiology
Bjorn Reinius, Martin M. Johansson, Katarzyna J. Radomska, Edward H. Morrow, Gaurav K. Pandey, Chandrasekhar Kanduri, Rickard Sandberg, Robert W. Williams, Elena Jazin
Article
Biochemistry & Molecular Biology
Katarzyna J. Radomska, Jonatan Halvardson, Bjorn Reinius, Eva Lindholm Carlstrom, Lina Emilsson, Lars Feuk, Elena Jazin
HUMAN MOLECULAR GENETICS
(2013)
Article
Biochemistry & Molecular Biology
M. Y. M. Ng, D. F. Levinson, S. V. Faraone, B. K. Suarez, L. E. DeLisi, T. Arinami, B. Riley, T. Paunio, A. E. Pulver, Irmansyah, P. A. Holmans, M. Escamilla, D. B. Wildenauer, N. M. Williams, C. Laurent, B. J. Mowry, L. M. Brzustowicz, M. Maziade, P. Sklar, D. L. Garver, G. R. Abecasis, B. Lerer, M. D. Fallin, H. M. D. Gurling, P. V. Gejman, E. Lindholm, H. W. Moises, W. Byerley, E. M. Wijsman, P. Forabosco, M. T. Tsuang, H-G Hwu, Y. Okazaki, K. S. Kendler, B. Wormley, A. Fanous, D. Walsh, F. A. O'Neill, L. Peltonen, G. Nestadt, V. K. Lasseter, K. Y. Liang, G. M. Papadimitriou, D. G. Dikeos, S. G. Schwab, M. J. Owen, M. C. O'Donovan, N. Norton, E. Hare, H. Raventos, H. Nicolini, M. Albus, W. Maier, V. L. Nimgaonkar, L. Terenius, J. Mallet, M. Jay, S. Godard, D. Nertney, M. Alexander, R. R. Crowe, J. M. Silverman, A. S. Bassett, M-A Roy, C. Merette, C. N. Pato, M. T. Pato, J. Louw Roos, Y. Kohn, D. Amann-Zalcenstein, G. Kalsi, A. McQuillin, D. Curtis, J. Brynjolfson, T. Sigmundsson, H. Petursson, A. R. Sanders, J. Duan, E. Jazin, M. Myles-Worsley, M. Karayiorgou, C. M. Lewis
MOLECULAR PSYCHIATRY
(2009)
Letter
Biochemistry & Molecular Biology
B. Reinius, E. Jazin
MOLECULAR PSYCHIATRY
(2009)
Review
Neurosciences
Elena Jazin, Larry Cahill
NATURE REVIEWS NEUROSCIENCE
(2010)
Article
Multidisciplinary Sciences
Lin Jiang, Peter Saetre, Katarzyna J. Radomska, Elena Jazin, Eva Lindholm Carlstrom
Article
Genetics & Heredity
Bjoern Reinius, Peter Saetre, Jennifer A. Leonard, Ran Blekhman, Roxana Merino-Martinez, Yoav Gilad, Elena Jazin
Article
Genetics & Heredity
Martin M. Johansson, Philipp Pottmeier, Pascalina Suciu, Tauseef Ahmed, Ammar Zaghlool, Jonatan Halvardson, Elisabeth Darj, Lars Feuk, Christiane Peuckert, Elena Jazin
FRONTIERS IN GENETICS
(2019)
Article
Neurosciences
B. Farnsworth, K. J. Radomska, B. Zimmermann, P. Kettunen, E. Jazin, L. S. Emilsson
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.
