Autophagy regulates inflammation following oxidative injury in diabetes

Connecting Type 1 and Type 2 Diabetes through Innate Immunity

(2013) J. I. Odegaard et al.   Cold Spring Harbor Perspectives in Medicine

Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells

(2012) Wenying Quan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Oxidative stress and inflammation interactions in human obesity

(2012) Isabel Bondia-Pons et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes

(2012) Maria J. Pereira et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Focus on Vitamin D, Inflammation and Type 2 Diabetes

(2012) Carlos Eduardo Andrade Chagas et al.   Nutrients

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

(2011) M. Mraz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

(2011) Tania O. Crişan et al.   PLoS One

Excessive Food Intake, Obesity and Inflammation Process in Zucker fa/fa Rat Pancreatic Islets

(2011) Myriam Chentouf et al.   PLoS One

The double-edged effect of autophagy in pancreatic beta cells and diabetes

(2010) Ze-fang Chen et al.   Autophagy

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

(2010) Fabrice Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

β-cell autophagy: A novel mechanism regulating β-cell function and mass- Lessons from β-cell-specific Atg7-deficient mice

(2010) Yoshio Fujitani et al.   Islets

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagic Components Contribute to Hypersensitive Cell Death in Arabidopsis

(2009) Daniel Hofius et al.   CELL

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

(2009) James D. Johnson et al.   CELL TRANSPLANTATION

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Autophagy Regulates Pancreatic Beta Cell Death in Response to Pdx1 Deficiency and Nutrient Deprivation

(2009) Kei Fujimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

(2009) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism

(2009) Makiko Shimodahira et al.   JOURNAL OF ENDOCRINOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Induces Autophagy in Islets: Relevance in Islet Transplantation

(2009) M. Tanemura et al.   TRANSPLANTATION PROCEEDINGS

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE