Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

(2011) Tania O. Crişan et al.   PLoS One

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

(2010) Shinsuke Oh-I et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

(2010) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activation

(2010) Yoshimi Fujishima et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

(2010) G. Sabio et al.   GENES & DEVELOPMENT

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of autophagy in pancreatic β-cell and diabetes

(2009) Yoshio Fujitani et al.   Autophagy

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Functional Role of c-Jun-N-Terminal Kinase in Feeding Regulation

(2009) Elizabeth K. Unger et al.   ENDOCRINOLOGY

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia

(2009) J.-A Lee et al.   JOURNAL OF NEUROSCIENCE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

(2008) Jae-Sung Kim et al.   HEPATOLOGY

Autophagy in the liver

(2008) Xiao-Ming Yin et al.   HEPATOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE