Angiogenesis in pancreatic cancer: current research status and clinical implications

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice

(2017) Sho Endo et al.   GASTROENTEROLOGY

Overexpression of G protein-coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates NF-κB signaling pathway

(2017) Li Wang et al.   Molecular Cancer

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors

(2017) Allison S. Harney et al.   MOLECULAR CANCER THERAPEUTICS

4-Methylumbelliferone Suppresses Hyaluronan Synthesis and Tumor Progression in SCID Mice Intra-abdominally Inoculated With Pancreatic Cancer Cells

(2017) Hayato Nagase et al.   PANCREAS

Contribution of pericyte paracrine regulation of the endothelium to angiogenesis

(2017) A. Caporali et al.   PHARMACOLOGY & THERAPEUTICS

HIF-2α promotes the formation of vasculogenic mimicry in pancreatic cancer by regulating the binding of Twist1 to the VE-cadherin promoter

(2017) Jian Yang et al.   Oncotarget

Elevated COX-2 Expression Promotes Angiogenesis Through EGFR/p38-MAPK/Sp1-Dependent Signalling in Pancreatic Cancer

(2017) Hai Hu et al.   Scientific Reports

Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer

(2017) Michael D. Nieskoski et al.   Scientific Reports

Selection of an early biomarker for vascular normalization using dynamic contrast-enhanced ultrasonography to predict outcomes of metastatic patients treated with bevacizumab

(2016) N. Lassau et al.   ANNALS OF ONCOLOGY

Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors

(2016) MONICA CAPOZZI et al.   ANTICANCER RESEARCH

Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer

(2016) Srinivasa P Pothula et al.   BRITISH JOURNAL OF CANCER

Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

(2016) Maud-Emmanuelle Gilles et al.   CANCER RESEARCH

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

(2016) S. R. Hingorani et al.   CLINICAL CANCER RESEARCH

Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Anusha Kalbasi et al.   CLINICAL CANCER RESEARCH

Pharmacological macrophage inhibition decreases metastasis formation in a genetic model of pancreatic cancer

(2016) Heidi Griesmann et al.   GUT

Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

(2016) Victoria L Bridgeman et al.   JOURNAL OF PATHOLOGY

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

(2016) Sophia Frentzas et al.   NATURE MEDICINE

Low Stromal Area and High Stromal Microvessel Density Predict Poor Prognosis in Pancreatic Cancer

(2016) Takahiro Nishida et al.   PANCREAS

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

(2016) Francesco Di Maggio et al.   PANCREATOLOGY

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

(2016) Lih Yin Tan et al.   Oncotarget

Concise Review: Pancreatic Cancer and Bone Marrow-Derived Stem Cells

(2016) Wojciech Błogowski et al.   Stem Cells Translational Medicine

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Exposure-response analysis of rilotumumab in gastric cancer: the role of tumour MET expression

(2015) M Zhu et al.   BRITISH JOURNAL OF CANCER

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma

(2015) Sonja Berchtold et al.   CANCER LETTERS

Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer: PEGASUS-PC Study

(2015) Hiroki Yamaue et al.   CANCER SCIENCE

Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer

(2015) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling

(2015) Fei Niu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TLR9 ligation in pancreatic stellate cells promotes tumorigenesis

(2015) Constantinos P. Zambirinis et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma

(2015) Hexige Saiyin et al.   JOURNAL OF PATHOLOGY

Targeted nuclear factor-kappaB suppression enhances gemcitabine response in human pancreatic tumor cell line murine xenografts

(2015) Joshua A. Waters et al.   SURGERY

TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis

(2015) Jesse Gore et al.   Oncotarget

Vascular Normalization Induced by Sinomenine Hydrochloride Results in Suppressed Mammary Tumor Growth and Metastasis

(2015) Huimin Zhang et al.   Scientific Reports

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors

(2015) Patrick A. Murphy et al.   PLoS One

Neutrophil Elastase-Generated Fragment of Vascular Endothelial Growth Factor-A Stimulates Macrophage and Endothelial Progenitor Cell Migration

(2015) Elma Kurtagic et al.   PLoS One

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

STAT5b as Molecular Target in Pancreatic Cancer—Inhibition of Tumor Growth, Angiogenesis, and Metastases

(2015) Christian Moser et al.   NEOPLASIA

Intussusceptive angiogenesis: expansion and remodeling of microvascular networks

(2014) Steven J. Mentzer et al.   ANGIOGENESIS

Serum tryptase, mast cells positive to tryptase and microvascular density evaluation in early breast cancer patients: possible translational significance

(2014) Ilaria Marech et al.   BMC CANCER

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Phase II trial of vatalanib in patients with advanced or metastatic pancreatic adenocarcinoma after first-line gemcitabine therapy (PCRT O4-001)

(2014) T. Dragovich et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell–endothelial cell interactions: antiangiogenic implications in pancreatic cancer

(2014) Mishaal B. Patel et al.   CARCINOGENESIS

Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies

(2014) Jonathan Haqq et al.   EUROPEAN JOURNAL OF CANCER

Ginsenoside Rg3 inhibition of vasculogenic mimicry in pancreatic cancer through downregulation of VE-cadherin/EphA2/MMP9/MMP2 expression

(2014) JING-QIANG GUO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

Vascular Endothelial Growth Factor-B in Physiology and Disease

(2014) Maija Bry et al.   PHYSIOLOGICAL REVIEWS

Correlation between Serum Tryptase, Mast Cells Positive to Tryptase and Microvascular Density in Colo-Rectal Cancer Patients: Possible Biological-Clinical Significance

(2014) Michele Ammendola et al.   PLoS One

Fluid shear stress threshold regulates angiogenic sprouting

(2014) P. A. Galie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth

(2014) Aihua Li et al.   Translational Oncology

Antiangiogenic Therapy Using Sunitinib Combined with Rapamycin Retards Tumor Growth But Promotes Metastasis

(2014) Tao Yin et al.   Translational Oncology

Mast Cells Density Positive to Tryptase Correlates with Angiogenesis in Pancreatic Ductal Adenocarcinoma Patients Having Undergone Surgery

(2014) Michele Ammendola et al.   Gastroenterology Research and Practice

Pioglitazone inhibits the proliferation and metastasis of human pancreatic cancer cells

(2014) ITASU NINOMIYA et al.   Oncology Letters

Antiangiogenic therapy promoted metastasis of hepatocellular carcinoma by suppressing host-derived interleukin-12b in mouse models

(2013) Xiao-Dong Zhu et al.   ANGIOGENESIS

Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells

(2013) Ivanka Dimova et al.   ANGIOGENESIS

VEGFR-2, CXCR-2 and PAR-1 germline polymorphisms as predictors of survival in pancreatic carcinoma

(2013) F. G. Uzunoglu et al.   ANNALS OF ONCOLOGY

Vascular proliferation is associated with survival in pancreatic ductal adenocarcinoma

(2013) Dag Hoem et al.   APMIS

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy

(2013) Y. Huang et al.   CANCER RESEARCH

Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer

(2013) Ying Ma et al.   CANCER RESEARCH

Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma

(2013) K. Y. Aguilera et al.   CANCER RESEARCH

Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer

(2013) Philippe Rougier et al.   EUROPEAN JOURNAL OF CANCER

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression

(2013) Simone Polvani et al.   INTERNATIONAL JOURNAL OF CANCER

Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors

(2013) Barbara Vizio et al.   Journal of Translational Medicine

Induction of M2-macrophages by tumour cells and tumour growth promotion by M2-macrophages: A quid pro quo in pancreatic cancer

(2013) L.I. Partecke et al.   PANCREATOLOGY

Intratumoral α-SMA Enhances the Prognostic Potency of CD34 Associated with Maintenance of Microvessel Integrity in Hepatocellular Carcinoma and Pancreatic Cancer

(2013) Wen-Quan Wang et al.   PLoS One

Digitoflavone Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNFα through Downregulation of Expression of Nuclear Factor κB-Regulated Gene Products in Human Pancreatic Cancer Cells

(2013) Xueting Cai et al.   PLoS One

High microvessel density in pancreatic ductal adenocarcinoma is associated with high grade

(2013) Anca Barău et al.   VIRCHOWS ARCHIV

Pancreatic cancer-associated stellate cells

(2013) Thomas A Mace et al.   OncoImmunology

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors

(2013) Florence Schaffner et al.   Cancers

VEGF over-expression in skeletal muscle induces angiogenesis by intussusception rather than sprouting

(2012) Roberto Gianni-Barrera et al.   ANGIOGENESIS

BAYPAN study: a double-blind phase III randomized trial comparing gemcitabine plus sorafenib and gemcitabine plus placebo in patients with advanced pancreatic cancer

(2012) A. Gonçalves et al.   ANNALS OF ONCOLOGY

Clinical Significance of Folate Receptor β–expressing Tumor-associated Macrophages in Pancreatic Cancer

(2012) Hiroshi Kurahara et al.   ANNALS OF SURGICAL ONCOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head

(2012) Kiyoshi Yoshikawa et al.   CANCER SCIENCE

Role of angiogenesis in the pathogenesis of cancer

(2012) Paulo M. Hoff et al.   CANCER TREATMENT REVIEWS

The histological growth pattern of colorectal cancer liver metastases has prognostic value

(2012) Gert G. Van den Eynden et al.   CLINICAL & EXPERIMENTAL METASTASIS

Expression of Specificity Protein Transcription Factors in Pancreatic Cancer and their Association in Prognosis and Therapy

(2012) Umesh T. Sankpal et al.   CURRENT MEDICINAL CHEMISTRY

Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis

(2012) Chen Huang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

NF-κB as a target for pancreatic cancer therapy

(2012) Carmine Carbone et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Disruption of Notch1 Induces Vascular Remodeling, Intussusceptive Angiogenesis, and Angiosarcomas in Livers of Mice

(2012) Michael T. Dill et al.   GASTROENTEROLOGY

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization

(2012) Wen-Quan Wang et al.   Journal of Hematology & Oncology

Synthetic mast-cell granules as adjuvants to promote and polarize immunity in lymph nodes

(2012) Ashley L. St. John et al.   NATURE MATERIALS

MUC1 regulates PDGFA expression during pancreatic cancer progression

(2012) M Sahraei et al.   ONCOGENE

Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer

(2012) Kristen S. Hill et al.   PLoS One

A New Mechanism for Pillar Formation during Tumor-Induced Intussusceptive Angiogenesis: Inverse Sprouting

(2011) Sándor Paku et al.   AMERICAN JOURNAL OF PATHOLOGY

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

(2011) Dirk Bausch et al.   ANGIOGENESIS

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

Polarization of Tumor-Associated Macrophages: A Novel Strategy for Vascular Normalization and Antitumor Immunity

(2011) Yuhui Huang et al.   CANCER CELL

Combined Blockade of Integrin- 4 1 Plus Cytokines SDF-1  or IL-1  Potently Inhibits Tumor Inflammation and Growth

(2011) M. C. Schmid et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Differential microstructure and physiology of brain and bone metastases in a rat breast cancer model by diffusion and dynamic contrast enhanced MRI

(2011) Matthew D. Budde et al.   CLINICAL & EXPERIMENTAL METASTASIS

Angiogenesis: A prognostic determinant in pancreatic cancer?

(2011) Jill A. van der Zee et al.   EUROPEAN JOURNAL OF CANCER

StellaTUM: current consensus and discussion on pancreatic stellate cell research

(2011) Mert Erkan et al.   GUT

Use of a Mouse Model of Pancreatic Neuroendocrine Tumors to Find Pericyte Biomarkers of Resistance to Anti-angiogenic Therapy

(2011) M. Franco et al.   HORMONE AND METABOLIC RESEARCH

Escape mechanisms after antiangiogenic treatment, or why are the tumors growing again?

(2011) Ruslan Hlushchuk et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

STAT3-targeting RNA interference inhibits pancreatic cancer angiogenesis in vitro and in vivo

(2011) Zheng-Jun Qiu   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

The chemotactic interaction between CCL21 and its receptor, CCR7, facilitates the progression of pancreatic cancer via induction of angiogenesis and lymphangiogenesis

(2011) Bin Zhao et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study

(2011) Hedy L Kindler et al.   LANCET ONCOLOGY

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma

(2011) P. Y. Wen et al.   NEURO-ONCOLOGY

Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors

(2011) Eric Raymond et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development

(2011) S M Pyonteck et al.   ONCOGENE

Increasing Incidence of Brain Metastasis in Patients with Advanced Hepatocellular Carcinoma in the Era of Antiangiogenic Targeted Therapy

(2011) Y.-Y. Shao et al.   ONCOLOGIST

STAT3 Knockdown Reduces Pancreatic Cancer Cell Invasiveness and Matrix Metalloproteinase-7 Expression in Nude Mice

(2011) Hai dong Li et al.   PLoS One

Benzyl Isothiocyanate Suppresses Pancreatic Tumor Angiogenesis and Invasion by Inhibiting HIF-α/VEGF/Rho-GTPases: Pivotal Role of STAT-3

(2011) Srinivas Reddy Boreddy et al.   PLoS One

Phase II and Coagulation Cascade Biomarker Study of Bevacizumab With or Without Docetaxel in Patients With Previously Treated Metastatic Pancreatic Adenocarcinoma

(2010) Igor A. Astsaturov et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis

(2010) Zhihong Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Signalling pathways in vasculogenic mimicry

(2010) Yvette W.J. Paulis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells

(2010) Harald J. Maier et al.   CANCER LETTERS

Novel STAT3 Phosphorylation Inhibitors Exhibit Potent Growth-Suppressive Activity in Pancreatic and Breast Cancer Cells

(2010) L. Lin et al.   CANCER RESEARCH

Pilot study to relate clinical outcome in pancreatic carcinoma and angiogenic plasma factors/circulating mature/progenitor endothelial cells: Preliminary results

(2010) Barbara Vizio et al.   CANCER SCIENCE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination

(2010) Einar K. Rofstad et al.   INTERNATIONAL JOURNAL OF CANCER

Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)

(2010) Hedy Lee Kindler et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase III Study of Bevacizumab Plus Docetaxel Compared With Placebo Plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer

(2010) David W. Miles et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival

(2010) Bernard Escudier et al.   JOURNAL OF CLINICAL ONCOLOGY

Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial

(2010) Roy S Herbst et al.   LANCET ONCOLOGY

Antiangiogenic therapy accelerates tumor metastasis

(2010) Domenico Ribatti   LEUKEMIA RESEARCH

Prognostic significance and mechanisms of patterned matrix vasculogenic mimicry in hepatocellular carcinoma

(2010) Wen-bin Liu et al.   MEDICAL ONCOLOGY

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Hedgehog Promotes Neovascularization in Pancreatic Cancers by Regulating Ang-1 and IGF-1 Expression in Bone-Marrow Derived Pro-Angiogenic Cells

(2010) Kazumasa Nakamura et al.   PLoS One

Prognostic significance of mast cell count following curative resection for pancreatic ductal adenocarcinoma

(2010) Shou-Wang Cai et al.   SURGERY

Thrombosis associated with angiogenesis inhibitors

(2009) Francesca Elice et al.   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

N-myc Downstream Regulated Gene 1/Cap43 Suppresses Tumor Growth and Angiogenesis of Pancreatic Cancer through Attenuation of Inhibitor of  B Kinase   Expression

(2009) F. Hosoi et al.   CANCER RESEARCH

Decreased Blood Flow with Increased Metabolic Activity: A Novel Sign of Pancreatic Tumor Aggressiveness

(2009) G. Komar et al.   CLINICAL CANCER RESEARCH

CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer

(2009) Yoichi Matsuo et al.   INTERNATIONAL JOURNAL OF CANCER

Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

(2009) Maria Galluzzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

(2009) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase III Trial of Bevacizumab in Combination With Gemcitabine and Erlotinib in Patients With Metastatic Pancreatic Cancer

(2009) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells

(2009) Rihong Cong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

(2009) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL RESEARCH

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Anticancer strategies involving the vasculature

(2009) Victoria L. Heath et al.   Nature Reviews Clinical Oncology

An overview of small-molecule inhibitors of VEGFR signaling

(2009) S. Percy Ivy et al.   Nature Reviews Clinical Oncology

Neuroendocrine Tumors of the Pancreas

(2009) F. Ehehalt et al.   ONCOLOGIST

FDA Drug Approval Summary: Bevacizumab (Avastin(R)) as Treatment of Recurrent Glioblastoma Multiforme

(2009) M. H. Cohen et al.   ONCOLOGIST

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

(2009) Binzhi Qian et al.   PLoS One

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

(2009) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The angiogenic switch in carcinogenesis

(2009) Vanessa Baeriswyl et al.   SEMINARS IN CANCER BIOLOGY

Tumor Recovery by Angiogenic Switch from Sprouting to Intussusceptive Angiogenesis after Treatment with PTK787/ZK222584 or Ionizing Radiation

(2008) Ruslan Hlushchuk et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression Profiling of Galectin-3-Depleted Melanoma Cells Reveals its Major Role in Melanoma Cell Plasticity and Vasculogenic Mimicry

(2008) Alexandra A. Mourad-Zeidan et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

(2008) Atsushi Masamune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neutrophil Gelatinase-Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

(2008) Z. Tong et al.   CANCER RESEARCH

Vascular Endothelial Growth Factor Receptor 2 Mediates Macrophage Infiltration into Orthotopic Pancreatic Tumors in Mice

(2008) S. P. Dineen et al.   CANCER RESEARCH

Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells

(2008) Madoka Yamazaki et al.   CANCER SCIENCE

CXCL8/IL-8 and CXCL12/SDF-1α co-operatively promote invasiveness and angiogenesis in pancreatic cancer

(2008) Yoichi Matsuo et al.   INTERNATIONAL JOURNAL OF CANCER

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hyaluronan: A constitutive regulator of chemoresistance and malignancy in cancer cells

(2008) Bryan P. Toole et al.   SEMINARS IN CANCER BIOLOGY

CXCL14 expression and potential function in pancreatic cancer

(2007) Moritz N. Wente et al.   CANCER LETTERS