Cbl-b-dependent degradation of FLIPLis involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells

Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b-Regulated T Cell Functions

(2011) M. Paolino et al.   JOURNAL OF IMMUNOLOGY

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

(2011) Emma Sandilands et al.   NATURE CELL BIOLOGY

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

(2011) Y. Kobashigawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

(2010) P. Isakson et al.   BLOOD

Arsenic trioxide — An old drug rediscovered

(2010) Ashkan Emadi et al.   BLOOD REVIEWS

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1  and Bcl-2 and Activating the Beclin 1/hVps34 Complex

(2010) X. Li et al.   CANCER RESEARCH

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Autophagy Is a Critical Mechanism for the Induction of the Antileukemic Effects of Arsenic Trioxide

(2010) Dennis J. Goussetis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways

(2009) Hui-Wen Chiu et al.   Autophagy

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)

(2009) G. Kchour et al.   BLOOD

Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation

(2009) Yingchun Li et al.   CANCER LETTERS

Ubiquitin ligase Cbl-b sensitizes leukemia and gastric cancer cells to anthracyclines by activating the mitochondrial pathway and modulating Akt and ERK survival signals

(2009) Xiujuan Qu et al.   FEBS LETTERS

FLIP-mediated autophagy regulation in cell death control

(2009) Jong-Soo Lee et al.   NATURE CELL BIOLOGY

A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis

(2009) Manikuntala Kundu et al.   NATURE IMMUNOLOGY

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Safety and efficacy of arsenic trioxide for patients with advanced metastatic melanoma

(2008) Ahmad A. Tarhini et al.   CANCER

Arsenic trioxide, thalidomide and retinoid acid combination therapy in higher risk myelodysplastic syndrome patients

(2007) Wen-Li Zheng et al.   LEUKEMIA RESEARCH