Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

Stably paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor triptolide

(2015) Fei Chen et al.   GENES & DEVELOPMENT

Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs

(2014) Wee-Wei Tee et al.   CELL

CFLAR/c-FLIPL

(2013) Ming-Xiao He et al.   Autophagy

Minnelide reduces tumor burden in preclinical models of osteosarcoma

(2013) Sulagna Banerjee et al.   CANCER LETTERS

The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila

(2013) C. Villicana et al.   JOURNAL OF CELL SCIENCE

Simultaneous determination of triptolide and its prodrug MC002 in dog blood by LC–MS/MS and its application in pharmacokinetic studies

(2013) Xiao-Mei Zhuang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Role of c-FLIP in Cisplatin Resistance of Human Bladder Cancer Cells

(2013) Sangchul Lee et al.   JOURNAL OF UROLOGY

Lymphoblastoid cell lines in pharmacogenomics: how applicable are they to clinical outcomes?

(2013) Amy L Stark et al.   PHARMACOGENOMICS

Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system

(2013) Jing Jiang et al.   Frontiers in Genetics

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

(2012) Donal McLornan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Triptolide Inhibits MDM2 and Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through a p53-Independent Pathway

(2012) M. Huang et al.   MOLECULAR CANCER THERAPEUTICS

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine

(2011) Zi Liu et al.   MOLECULES

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Functional complementation between FADD and RIP1 in embryos and lymphocytes

(2011) Haibing Zhang et al.   NATURE

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation

(2011) Heather E Wheeler et al.   PHARMACOGENOMICS

RNA polymerase – An important molecular target of triptolide in cancer cells

(2010) Jingxuan Pan   CANCER LETTERS

Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells

(2010) Fei Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of Hsp-70 in Triptolide-Mediated Cell Death of Neuroblastoma

(2010) Mara B. Antonoff et al.   JOURNAL OF SURGICAL RESEARCH

Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells

(2010) Gui-Sheng Zhou et al.   LEUKEMIA RESEARCH

A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals

(2009) Brian L. Browning et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein

(2009) N. Ueffing et al.   BLOOD

Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1

(2009) Qi Chen et al.   CANCER LETTERS

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

(2009) J.J.E.M. Kitzen et al.   EUROPEAN JOURNAL OF CANCER

A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data

(2009) Nuno L. Barbosa-Morais et al.   NUCLEIC ACIDS RESEARCH