Novel Phosphorylation and Ubiquitination Sites Regulate Reactive Oxygen Species-dependent Degradation of Anti-apoptotic c-FLIP Protein

The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Paraquat induces lung alveolar epithelial cell apoptosis via Nrf-2-regulated mitochondrial dysfunction and ER stress

(2012) Ya-Wen Chen et al.   ARCHIVES OF TOXICOLOGY

Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor-Targeted Therapy

(2012) C. McCourt et al.   CLINICAL CANCER RESEARCH

The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes

(2012) Jörn M. Schattenberg et al.   FREE RADICAL BIOLOGY AND MEDICINE

CHOP down-regulates cFLIPLexpression by promoting ubiquitin/proteasome-mediated cFLIPLdegradation

(2012) Hyo-Jeong Noh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2

(2011) Rosa Martín-Pérez et al.   APOPTOSIS

5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells

(2011) Jian-Feng Yang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

(2011) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Synthetic Triterpenoid Cyano Enone of Methyl Boswellate Activates Intrinsic, Extrinsic, and Endoplasmic Reticulum Stress Cell Death Pathways in Tumor Cell Lines

(2011) P. Ravanan et al.   MOLECULAR CANCER THERAPEUTICS

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

(2011) Andrew Oberst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIV Infection Enhances TRAIL-Induced Cell Death in Macrophage by Down-Regulating Decoy Receptor Expression and Generation of Reactive Oxygen Species

(2011) Dan-Ming Zhu et al.   PLoS One

Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

(2011) Ahmad R. Safa et al.   Cancers

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis

(2010) Venturina Stagni et al.   CARCINOGENESIS

Cardiac-specific overexpression of catalase attenuates paraquat-induced myocardial geometric and contractile alteration: Role of ER stress

(2010) We Ge et al.   FREE RADICAL BIOLOGY AND MEDICINE

Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins

(2010) Lee   INTERNATIONAL JOURNAL OF ONCOLOGY

Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL

(2010) Rosario Yerbes et al.   INVESTIGATIONAL NEW DRUGS

Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

(2010) Richa Tiwary et al.   PLoS One

Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells

(2009) Nicolas Dejeans et al.   BIOCHEMICAL PHARMACOLOGY

Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism

(2009) Dorrah Deeb et al.   BIOCHEMICAL PHARMACOLOGY

PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability

(2009) A Kaunisto et al.   CELL DEATH AND DIFFERENTIATION

Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents

(2009) T Sánchez-Pérez et al.   CELL DEATH AND DIFFERENTIATION

Activation-induced Degradation of FLIPLIs Mediated via the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Macrophages

(2009) Bo Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells

(2009) Wonsuk Yang et al.   TOXICOLOGY LETTERS

Cisplatin Induces p53-Dependent FLICE-Like Inhibitory Protein Ubiquitination in Ovarian Cancer Cells

(2008) M. R. Abedini et al.   CANCER RESEARCH

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

(2008) Yu Xue et al.   MOLECULAR & CELLULAR PROTEOMICS

Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells

(2008) Y. Lin et al.   MOLECULAR CANCER THERAPEUTICS

FLIP and the death effector domain family

(2008) J W Yu et al.   ONCOGENE

Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist

(2008) A. J. Frew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA