Article
Dermatology
Y. Luo, Y. Rao, X. Gu, P. Chai, Y. Yang, J. Lin, X. Xu, R. Jia, S. Xu
Summary: EPSCC shows distinct genetic characteristics, with damaging mutations in genes like KMT2C, which worsen the prognosis and contribute to the early onset of the disease.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Medicine, General & Internal
Sara I. Van Acker, Bert Van den Bogerd, Michel Haagdorens, Carina Koppen, Isabel Pintelon
Summary: Tissue-engineered products have the potential to repair tissue defects and reconstruct the ocular surface. However, proper cellular characterization of these products has been neglected. This study evaluated the accuracy of markers for identifying differentiated conjunctival-derived cells and emphasized their importance in assessing the safety and efficacy of tissue-engineered products.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Till Jasper Meyer, Manuel Stoth, Helena Moratin, Pascal Ickrath, Marietta Herrmann, Norbert Kleinsasser, Rudolf Hagen, Stephan Hackenberg, Agmal Scherzad
Summary: The study revealed that wound fluid contains high concentrations of proinflammatory cytokines. Tumor cells cultured with wound fluid showed increased proliferation rates and potential induction of epithelial-mesenchymal transition. This could be a mechanism for cisplatin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Abanoob F. Tadrosse, Marina F. Tadrosse, Bishoy M. Ezzat, Dina M. Sadek, Paul D. Langer
Summary: The purpose of this study was to investigate the risk of second primary neoplasms (SPNs) in patients with primary sebaceous carcinoma of the eyelid (SCE). The study found that SCE patients had a significantly increased risk of developing SPNs, including the lungs, pancreas, salivary glands, and skin. Caucasian women aged 40 to 54 were at the highest risk of developing SPNs, and women also had an increased risk of breast cancer and chronic lymphocytic leukemia.
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Dermatology
Soo Young Lee, Minho Lee, Dong Soo Yu, Young Bok Lee
Summary: This study investigated the genetic mutations of cutaneous squamous cell carcinomas (cSCCs) in Korean patients using whole-exome sequencing (WES). The findings showed that moderate to poor-differentiated cSCCs had a higher mutation burden and more driver mutations compared to well-differentiated cSCCs. Additionally, mutations in CSMD3, COL22A1, FMN2, and ASXL3 were found to be more frequent than in previous reports of cSCCs in Caucasians. These results contribute to our understanding of the tumorigenesis process in cSCC among non-Caucasian populations.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Cell Biology
Juanjuan Zhang, Ying Xu, Ying Zhao, Jingkun Bai, Mengge Xu, Chuanji Li, Jinyue Li, Yong Ren, Chang Xu, Yuguang Gao, Yan Sun, Xiaoying Liu
Summary: Loss of MSX2 leads to enamel defects and severe tooth wear in mice, affecting enamel formation. Studies have shown that the absence of MSX2 in ameloblasts may result in abnormal function of epithelial cells in the enamel organ, ultimately leading to enamel abnormalities.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Dermatology
Keisuke Goto, Shusuke Yoshikawa, Yoshio Kiyohara, Toru Kurimoto, Kyoko Nomi, Kohei Ogawa, Koichiro Tasaki, Manami Kajiwara, Toshitaka Nagao, Kazuhiko Umazume, Takuma Oishi
Summary: This study reveals the clinicopathologic characteristics of skin/conjunctival large cell neuroendocrine carcinoma (LCNEC), including the predominant location on the face, high metastatic and lethal potential, possible combination with other tumor components, and frequent mutant-type immunoexpressions of p53, PTEN, and Rb.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Review
Dermatology
Sara Mazzilli, Pensa Chiara, Gaetana Costanza, Alessandra Petruzzellis, Augusto Orlandi, Luca Bianchi, Elena Campione, Salvador Gonzalez, Paola Pasquali
Summary: Non-melanoma skin cancers (NMSCs), including basal and squamous cell carcinomas, are the most common malignancies among Caucasians, mainly due to chronic exposure to ultraviolet radiation. Currently, we have a better understanding of the pathophysiology and genetic risk factors of NMSCs.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nao Yamakado, Satoshi Okuda, Kei Tobiume, Ryo Uetsuki, Shigehiro Ono, Kuniko Mizuta, Takayuki Nakagawa, Tomonao Aikawa
Summary: Oral squamous cell carcinoma (SCC) is a tumor with bidirectional cell plasticity, and the chemical LSD1 inhibitor can induce EMT in the cell line OM-1. The induction of EMT is associated with the upregulation of EMT-TFs ZEB1 and Snail, as well as increased histone H3 methylation in the regulatory regions of ZEB1.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
K. Bokkers, G. W. J. Frederix, M. E. Velthuizen, M. van der Aa, C. G. Gerestein, E. B. L. van Dorst, J. G. Lange, J. A. Louwers, W. Koole, R. P. Zweemer, M. G. E. M. Ausems
Summary: This study demonstrates that using mainstream genetic testing pathways can significantly increase the proportion of newly diagnosed patients with epithelial ovarian cancer receiving germline genetic testing. Additionally, it significantly reduces genetics-related healthcare costs per patient.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Veterinary Sciences
Yasmin Najm Bortoletto, Julia de Assis Arantes, Alessandra Mayer Coelho, Lais Maria Gomes, Manuela Cristine Camargo Lambert, Ricardo De Francisco Strefezzi, Renata Gebara Sampaio Doria
Summary: This study presents the Destro VY skin advancement flap technique for blepharoplasty after surgical excision of SCC in horses, successfully preserving vision and aesthetics. The importance of surgical safety margins and complementary treatments in preventing tumor recurrence is emphasized.
ACTA SCIENTIAE VETERINARIAE
(2021)
Article
Dermatology
Keisuke Goto, Kazuyoshi Kajimoto, Takashi Sugino, Shin-ichi Nakatsuka, Makoto Yoshida, Mai Noto, Michihiro Kono, Toshihiro Takai
Summary: Adenoid cystic carcinoma (ACC) is an infiltrating carcinoma composed of myoepithelial and ductoglandular epithelial cells, with MYB break-apart signals observed in both p63-positive myoepithelial and p63-negative ductoglandular epithelial cells. Additionally, new patterns of cystic, papillary, and melting were proposed in addition to the previously described cribriform, tubular, and solid growth patterns.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2021)
Article
Cell Biology
Helena Paidassi, Mridu Acharya, Adam Lacy-Hulbert
CLEARANCE OF DYING CELLS IN HEALTHY AND DISEASED IMMUNE SYSTEMS
(2010)
Article
Hematology
Janine M. van Gils, Bhama Ramkhelawon, Luciana Fernandes, Merran C. Stewart, Liang Guo, Tara Seibert, Gustavo B. Menezes, Denise C. Cara, Camille Chow, T. Bernard Kinane, Edward A. Fisher, Mercedes Balcells, Jacqueline Alvarez-Leite, Adam Lacy-Hulbert, Kathryn J. Moore
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Oncology
Li Chen, Lynda Stuart, Toshiro K. Ohsumi, Shawn Burgess, Gaurav K. Varshney, Anahita Dastur, Mark Borowsky, Cyril Benes, Adam Lacy-Hulbert, Emmett V. Schmidt
Article
Developmental Biology
Shinya Hirota, Qian Liu, Hye Shin Lee, Mohammad G. Hossain, Adam Lacy-Hulbert, Joseph H. McCarty
Article
Gastroenterology & Hepatology
Helena Paidassi, Mridu Acharya, Ailiang Zhang, Subhankar Mukhopadhyay, Manjae Kwon, Camille Chow, Lynda M. Stuart, John Savill, Adam Lacy-Hulbert
Article
Gastroenterology & Hepatology
Barbara Cassani, Eduardo J. Villablanca, Francisco J. Quintana, Paul E. Love, Adam Lacy-Hulbert, William S. Blaner, Tim Sparwasser, Scott B. Snapper, Howard L. Weiner, J. Rodrigo Mora
Article
Immunology
Laurent Boyer, Lorin Magoc, Stephanie Dejardin, Michael Cappillino, Nicholas Paquette, Charlotte Hinault, Guillaume M. Charriere, W. K. Eddie Ip, Shannon Fracchia, Elizabeth Hennessy, Deniz Erturk-Hasdemir, Jean-Marc Reichhart, Neal Silverman, Adam Lacy-Hulbert, Lynda M. Stuart
Editorial Material
Immunology
Adam Lacy-Hulbert, Lynda M. Stuart
Article
Biochemistry & Molecular Biology
Beatriz Perez, Nicholas Paquette, Helena Paidassi, Bo Zhai, Kristin White, Rachel Skvirsky, Adam Lacy-Hulbert, Lynda M. Stuart
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Immunology
Janine M. van Gils, Merran C. Derby, Luciana R. Fernandes, Bhama Ramkhelawon, Tathagat D. Ray, Katey J. Rayner, Sajesh Parathath, Emilie Distel, Jessica L. Feig, Jacqueline I. Alvarez-Leite, Alistair J. Rayner, Thomas O. McDonald, Kevin D. O'Brien, Lynda M. Stuart, Edward A. Fisher, Adam Lacy-Hulbert, Kathryn J. Moore
Article
Immunology
Michael G. Overstreet, Alison Gaylo, Bastian R. Angermann, Angela Hughson, Young-Min Hyun, Kris Lambert, Mridu Acharya, Alison C. Billroth-MacLurg, Alexander F. Rosenberg, David J. Topham, Hideo Yagita, Minsoo Kim, Adam Lacy-Hulbert, Martin Meier-Schellersheim, Deborah J. Fowell
Article
Immunology
Anna Sokolovska, Christine E. Becker, W. K. Eddie Ip, Vijay A. K. Rathinam, Matthew Brudner, Nicholas Paquette, Antoine Tanne, Sivapriya K. Vanaja, Kathryn J. Moore, Katherine A. Fitzgerald, Adam Lacy-Hulbert, Lynda M. Stuart
Article
Biochemistry & Molecular Biology
Neil C. Henderson, Thomas D. Arnold, Yoshio Katamura, Marilyn M. Giacomini, Juan D. Rodriguez, Joseph H. McCarty, Antonella Pellicoro, Elisabeth Raschperger, Christer Betsholtz, Peter G. Ruminski, David W. Griggs, Michael J. Prinsen, Jacquelyn J. Maher, John P. Iredale, Adam Lacy-Hulbert, Ralf H. Adams, Dean Sheppard
Article
Multidisciplinary Sciences
Nanda Kumar N. Shanmugam, Shiri Ellenbogen, Estela Trebicka, Lijian Wang, Subhankar Mukhopadhyay, Adam Lacy-Hulbert, Carey Ann Gallini, Wendy S. Garrett, Bobby J. Cherayil
Article
Microbiology
Lyly G. Luhachack, Orane Visvikis, Amanda C. Wollenberg, Adam Lacy-Hulbert, Lynda M. Stuart, Javier E. Irazoqui