Article
Multidisciplinary Sciences
Jin-Seon Yook, Mikyoung You, Jiyoung Kim, Ashley M. Toney, Rong Fan, Bhanwar Lal Puniya, Tomas Helikar, Sophie Vaulont, Jean-Christophe Deschemin, Meshail Okla, Liwei Xie, Manik C. Ghosh, Tracey A. Rouault, Jaekwon Lee, Soonkyu Chung
Summary: This study investigates the iron-regulatory network underlying beige adipogenesis, showing that thermogenic stimulus leads to redistribution of iron into beige fat through interplay between adipocyte iron demands and systemic iron liberation. Disruption of systemic iron homeostasis impairs beige fat development, suggesting coordinated interplay between renal hypoxia and hepcidin down-regulation as a key mechanism for activating adaptive thermogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Long-jiao Wang, Guo-ping Zhao, Xi-fan Wang, Xiao-xue Liu, Yi-xuan Li, Li-li Qiu, Xiao-yu Wang, Fa-zheng Ren
Summary: Glycochenodeoxycholate (GCDCA), a steroid, can induce the expression of hepcidin and reduce serum iron levels. GCDCA regulates hepcidin by activating the FXR and BMP6/ALK3-SMAD signaling pathway.
Article
Pharmacology & Pharmacy
Mei-Mei Wu, Qiu-Mei Wang, Bao-Yuan Huang, Chu-Tian Mai, Chun-Li Wang, Tian-Tian Wang, Xiao-Jun Zhang
Summary: Restoring immune balance by targeting macrophage polarization with Dioscin is a promising therapeutic strategy for UC. Dioscin ameliorates colitis in mice by inhibiting M1 and promoting M2 macrophage polarization through modulation of mTOR signals. This protection is achieved by inhibiting aerobic glycolysis and promoting fatty acid oxidation in macrophages.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xinrui Arenbaoligao, Xinrui Guo, Jiahao Xiong, Shuangshuang Zhang, Yuewen Yang, Dapeng Chen, Yu Xie
Summary: The main ingredient in traditional Chinese medicinal cloves and Alpinia purpurata, kumatakenin, was found to inhibit epithelial ferroptosis in colonic tissues, thereby relieving clinical symptoms and improving endoscopic presentations in inflammatory bowel disease (IBD). Kumatakenin reduced cellular iron levels and suppressed ferroptosis in epithelial cells from colitis mice, at least partially through upregulating expression of enolase (Eno-3) and modulating the Eno3-iron regulatory protein (IRP1) axis. This study provides a scientific basis for the clinical use of kumatakenin in the treatment of colitis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Sachelly Julian-Serrano, Fangcheng Yuan, William Wheeler, Beben Benyamin, Mitchell J. Machiela, Alan A. Arslan, Laura E. Beane-Freeman, Paige M. Bracci, Eric J. Duell, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Charles Kooperberg, Loic Le Marchand, Rachel E. Neale, Xiao-Ou Shu, Stephen K. Van den Eeden, Kala Visvanathan, Wei Zheng, Demetrius Albanes, Gabriella Andreotti, Eva Ardanaz, Ana Babic, Sonja Berndt, Lauren K. Brais, Paul Brennan, Bas Bueno-de-Mesquita, Julie E. Buring, Stephen J. Chanock, Erica J. Childs, Charles C. Chung, Eleonora Fabianova, Lenka Foretova, Charles S. Fuchs, J. Michael Gaziano, Manuel Gentiluomo, Edward L. Giovannucci, Michael G. Goggins, Thilo Hackert, Patricia Hartge, Manal M. Hassan, Ivana Holcatova, Elizabeth A. Holly, Rayjean Hung, Vladimir Janout, Robert C. Kurtz, I-Min Lee, Nuria Malats, David McKean, Roger L. Milne, Christina C. Newton, Ann L. Oberg, Sandra Perdomo, Ulrike Peters, Miquel Porta, Nathaniel Rothman, Matthias B. Schulze, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jean Wactawski-Wende, Elisabete Weiderpass, Nicolas Wenstzensen, Emily White, Lynne R. Wilkens, Herbert Yu, Anne Zeleniuch-Jacquotte, Jun Zhong, Peter Kraft, Dounghui Li, Peter T. Campbell, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Laufey T. Amundadottir, Alison P. Klein, Kai Yu, Rachael Z. Stolzenberg-Solomon
Summary: The study found that the hepcidin-regulating gene pathway is associated with the risk of pancreatic ductal adenocarcinoma, with HJV, TFR2, TFR1, BMP6 and HAMP genes contributing the most to the association.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Azaan Saalim Wilbon, Jiemin Shen, Piotr Ruchala, Ming Zhou, Yaping Pan
Summary: Ferroportin (Fpn) is the only known iron exporter in humans and is regulated by hepcidin. Minihepcidins, small peptides that mimic the first few residues of hepcidin, show enhanced inhibition potency compared to hepcidin. This study presents the structure of human Fpn in complex with a minihepcidin, PR73, and reveals novel interactions between Fpn and minihepcidin. The results provide insights into the mechanism of enhanced inhibition by minihepcidins and have implications for developing Fpn inhibitors.
Article
Pharmacology & Pharmacy
Shuguang Yan, Hailiang Wei, Rui Jia, Meijia Zhen, Shengchuan Bao, Wenba Wang, Fanrong Liu, Jingtao Li
Summary: Wumeiwan has a preventive effect on ulcerative colitis by inhibiting pro-inflammatory cytokines, promoting anti-inflammatory factors, and affecting macrophage polarization, thereby protecting mice from DSS-induced colitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ke Lan, Huabing Yang, Junping Zheng, Haiming Hu, Tianxiang Zhu, Xiaojuan Zou, Baifei Hu, Hongtao Liu
Summary: Poria cocos oligosaccharides (PCOs) showed a protective effect on colitis by reversing gut microbiota dysbiosis.
Article
Cell Biology
Jagadish Ramasamy, Chinmai Jagadish, Abitha Sukumaran, Joe Varghese, Thenmozhi Mani, A. J. Joseph, Ebby George Simon, Molly Jacob
Summary: Ulcerative colitis (UC) is often accompanied by anemia. Hepcidin, the central regulator of iron homeostasis, is induced by inflammation and suppressed by anemia. The impact of UC on hepcidin is unclear, and this knowledge may have implications for treatment.
Article
Biology
Zhong-Da Li, Meng-Yu Geng, Song-Rui Dou, Xuan Wang, Zi-Han Zhang, Yan-Zhong Chang
Summary: Caffeine can decrease hepcidin expression by inhibiting inflammation and the activation of the IL-6/STAT3 pathway, suggesting it as a potential therapeutic for anemia of inflammation.
Article
Medicine, Research & Experimental
Jason Shieh, Timothy H. Chu, Yang Liu, Julie Kim, Ainara Ruiz de Sabando, Soma Kobayashi, Sui Y. Zee, Brian S. Sheridan, Agnieszka B. Bialkowska, Vincent W. Yang
Summary: This study demonstrates the role of Klf5 in Th17-dependent colonic inflammation and epithelial tissue regeneration. It also shows the impact of Klf5 deficiency on the colonic microbiota and the potential of antibiotic treatment in alleviating the inflammatory response.
Article
Neurosciences
Qihang Luo, Jun Zheng, Bin Fan, Jingying Liu, Weijing Liao, Xin Zhang
Summary: Enriched environment modulates iron metabolism to reduce ferroptosis and provides neuroprotection after ischemic stroke.
BRAIN RESEARCH BULLETIN
(2023)
Article
Cell Biology
Pelagia Foka, Alexios Dimitriadis, Eirini Karamichali, Emmanouil Kochlios, Petros Eliadis, Vaia Valiakou, John Koskinas, Avgi Mamalaki, Urania Georgopoulou
Summary: Iron plays a crucial role in the regulation of host innate immunity and the outcome of infections, particularly in the context of Hepatitis C virus (HCV). This study demonstrates the interplay between iron homeostasis and innate immunity in liver, intestine, and macrophages, highlighting the potential impact on early HCV infection and the establishment of viral persistence leading to chronic liver disease.
Article
Biochemistry & Molecular Biology
Yanwei Zhang, Xiaojuan Chi, Jingyun Hu, Shulin Wang, Senhong Zhao, Yanan Mao, Benqun Peng, Jilong Chen, Song Wang
Summary: Studies have shown that the long noncoding RNA LINC02574 is induced by influenza A virus (IAV) infection and plays a crucial role in inhibiting IAV replication. The expression of LINC02574 is stimulated by viral genomic RNA, poly (I:C), or interferons (IFNs) through the RIG-I-dependent interferon signaling pathway. Knockdown of LINC02574 impairs the expression of type I and type III IFNs, multiple ISGs, and the activation of STAT1 triggered by IAV infection, indicating that LINC02574 positively regulates the innate immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yoshihisa Uenoyama, Naoko Inoue, Sho Nakamura, Hiroko Tsukamura
Summary: Estrogen produced by ovarian follicles plays a crucial role in regulating the reproductive mechanisms in female mammals through the control of gonadotropin-releasing hormone release. Kisspeptin neurons have been identified as important mediators of estrogen's negative and positive feedback actions in governing GnRH neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Wanshui Yang, Li Liu, NaNa Keum, Zhi Rong Qian, Jonathan A. Nowak, Tsuyoshi Hamada, Mingyang Song, Yin Cao, Katsuhiko Nosho, Stephanie A. Smith-Warner, Sui Zhang, Yohei Masugi, Kimmie Ng, Keisuke Kosumi, Yanan Ma, Wendy S. Garrett, Molin Wang, Hongmei Nan, Marios Giannakis, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Reiko Nishihara, Kana Wu, Edward L. Giovannucci, Shuji Ogino, Xuehong Zhang
CANCER PREVENTION RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Sydney Lavoie, Eunyoung Chun, Sena Bae, Caitlin A. Brennan, Carey Ann Gallini Comeau, Jessica K. Lang, Monia Michaud, Hamid R. Hoveyda, Graeme L. Fraser, Miles H. Fuller, Brian T. Layden, Jonathan N. Glickman, Wendy S. Garrett
Article
Gastroenterology & Hepatology
Long H. Nguyen, Wenjie Ma, Dong D. Wang, Yin Cao, Himel Mallick, Teklu K. Gerbaba, Jason Lloyd-Price, Galeb Abu-Ali, A. Brantley Hall, Daniel Sikavi, David A. Drew, Raaj S. Mehta, Cesar Arze, Amit D. Joshi, Yan Yan, Tobyn Branck, Casey DuLong, Kerry L. Ivey, Shuji Ogino, Eric B. Rimm, Mingyang Song, Wendy S. Garrett, Jacques Izard, Curtis Huttenhower, Andrew T. Chan
Article
Immunology
Subhankar Mukhopadhyay, Eva Heinz, Immacolata Porreca, Kaur Alasoo, Amy Yeung, Huei-Ting Yang, Tobias Schwerd, Jessica L. Forbester, Christine Hale, Chukwuma A. Agu, Yoon Ha Choi, Julia Rodrigues, Melania Capitani, Luke Jostins-Dean, David C. Thomas, Simon Travis, Daniel Gaffney, William C. Skarnes, Nicholas Thomson, Holm H. Uhlig, Gordon Dougan, Fiona Powrie
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Review
Oncology
Siamon Gordon, Annette Pluddemann, Subhankar Mukhopadhyay
JOURNAL OF PATHOLOGY
(2020)
Article
Oncology
Koichiro Haruki, Keisuke Kosumi, Tsuyoshi Hamada, Tyler S. Twombly, Juha P. Vayrynen, Sun A. Kim, Yohei Masugi, Zhi Rong Qian, Kosuke Mima, Yoshifumi Baba, Annacarolina da Silva, Jennifer Borowsky, Kota Arima, Kenji Fujiyoshi, Mai Chan Lau, Peilong Li, Chunguang Guo, Yang Chen, Mingyang Song, Jonathan A. Nowak, Reiko Nishihara, Katsuhiko Yanaga, Xuehong Zhang, Kana Wu, Susan Bullman, Wendy S. Garrett, Curtis Huttenhower, Jeffrey A. Meyerhardt, Marios Giannakis, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino
JOURNAL OF PATHOLOGY
(2020)
Article
Microbiology
Yan Yan, David A. Drew, Arnold Markowitz, Jason Lloyd-Price, Galeb Abu-Ali, Long H. Nguyen, Christina Tran, Daniel C. Chung, Katherine K. Gilpin, Dana Meixell, Melanie Parziale, Madeline Schuck, Zalak Patel, James M. Richter, Peter B. Kelsey, Wendy S. Garrett, Andrew T. Chan, Zsofia K. Stadler, Curtis Huttenhower
CELL HOST & MICROBE
(2020)
Editorial Material
Medicine, General & Internal
Wendy S. Garrett
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Multidisciplinary Sciences
Nelson H. Knudsen, Kristopher J. Stanya, Alexander L. Hyde, Mayer M. Chalom, Ryan K. Alexander, Yae-Huei Liou, Kyle A. Starost, Matthew R. Gangl, David Jacobi, Sihao Liu, Danesh H. Sopariwala, Diogo Fonseca-Pereira, Jun Li, Frank B. Hu, Wendy S. Garrett, Vihang A. Narkar, Eric A. Ortlund, Jonathan H. Kim, Chad M. Paton, Jamie A. Cooper, Chih-Hao Lee
Article
Multidisciplinary Sciences
Lior Lobel, Y. Grace Cao, Kathrin Fenn, Jonathan N. Glickman, Wendy S. Garrett
Article
Multidisciplinary Sciences
Massimiliano Baldassarre, Virtu Solano-Collado, Arda Balci, Rosa A. Colamarino, Ivy M. Dambuza, Delyth M. Reid, Heather M. Wilson, Gordon D. Brown, Subhankar Mukhopadhyay, Gordon Dougan, Stefania Spano
Summary: The Rab32/BLOC-3 pathway in macrophages is a novel and crucial host immune defense mechanism that controls bacterial and fungal infection independently of other known antimicrobial mechanisms, helping mammals protect against various pathogens.
Article
Biochemistry & Molecular Biology
Jeremy E. Wilkinson, Eric A. Franzosa, Christine Everett, Chengchen Li, Frank B. Hu, Dyann F. Wirth, Mingyang Song, Andrew T. Chan, Eric Rimm, Wendy S. Garrett, Curtis Huttenhower
Summary: Microbiome science has rapidly advanced and is increasingly integrated into public health, providing opportunities for researchers, practitioners, and policymakers. There are opportunities for incorporating microbiome-based technologies into public health practice in the near future, along with a growing need for policymaking and regulation in related areas.
Review
Oncology
Geniver El Tekle, Wendy S. Garrett
Summary: Cancer cells originate from acquired genetic mutations that drive uncontrolled proliferation and immune evasion. Environmental factors, including the human microbiota, can influence tumor behavior and shape the tumor microenvironment. Dysbiosis of the gut microbiome is recognized as a hallmark of cancer. This review explores the role of microbiota in cancer initiation, promotion, and progression, focusing on gastrointestinal tract malignancies, as well as lung, breast, and prostate cancers. It also discusses the potential of targeting bacteria for personalized cancer prevention, diagnostics, and treatment.
NATURE REVIEWS CANCER
(2023)
Review
Medicine, Research & Experimental
Slater L. Clay, Diogo Fonseca-Pereira, Wendy S. Garrett
Summary: The microbiota plays an important role in the development of colorectal cancer (CRC). Identifying specific microbial features that impact CRC initiation and progression is crucial. Bacterial factors, such as toxins, contribute to colorectal carcinogenesis. However, further research is needed to understand the host determinants of a toxin's cancer-promoting effects. For bacteria associated with CRC but lacking toxins, defining cancer-relevant virulence factors is challenging. Additionally, gut microbes can have beneficial effects on CRC antitumor immunity through the production of certain metabolites.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Tiffany Hsu, Matthew R. Gemmell, Eric A. Franzosa, Susan Berry, Indrani Mukhopadhya, Richard Hansen, Monia Michaud, Hans Nielsen, William G. Miller, Henrik Nielsen, Mona Bajaj-Elliott, Curtis Huttenhower, Wendy S. Garrett, Georgina L. Hold
EMERGING MICROBES & INFECTIONS
(2019)