Current advances in the novel functions of hypoxia-inducible factor and prolyl hydroxylase in invertebrates

Expanding P450 catalytic reaction space through evolution and engineering

(2014) John A McIntosh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity inCaenorhabditis elegans

(2014) Ara B. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

(2014) Jennifer M. A. Tullet et al.   PLoS Genetics

Genetic Analysis of Hypoxia Tolerance and Susceptibility in Drosophila and Humans

(2013) Dan Zhou et al.   Annual Review of Genomics and Human Genetics

Agitation by Suffocation: How Hypoxia Activates Innate Immunity via the Warburg Effect

(2013) Haitao Wen et al.   Cell Metabolism

Role of Pore-Forming Toxins in Bacterial Infectious Diseases

(2013) F. C. O. Los et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Oxidative phosphorylation and ion transport in the mitochondria of two strains of rats varying in their resistance to stress and hypoxia

(2013) N. Venediktova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Cytochrome P450 Drives a HIF-Regulated Behavioral Response to Reoxygenation by C. elegans

(2013) D. K. Ma et al.   SCIENCE

Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies

(2012) Mariette Gerber   BRITISH JOURNAL OF NUTRITION

Increased Levels of Hydrogen Peroxide Induce a HIF-1-dependent Modification of Lipid Metabolism in AMPK Compromised C. elegans Dauer Larvae

(2012) Meng Xie et al.   Cell Metabolism

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

(2012) Jakob Bondo Hansen et al.   Cell Metabolism

Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism

(2012) Eun Chan Park et al.   EMBO JOURNAL

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

(2012) Norma Masson et al.   EMBO REPORTS

Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia

(2012) Helene Niecknig et al.   FREE RADICAL RESEARCH

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CYSL-1 Interacts with the O2-Sensing Hydroxylase EGL-9 to Promote H2S-Modulated Hypoxia-Induced Behavioral Plasticity in C. elegans

(2012) Dengke K. Ma et al.   NEURON

Hypoxia-Adaptation Involves Mitochondrial Metabolic Depression and Decreased ROS Leakage

(2012) Sameh S. Ali et al.   PLoS One

Ultrastructural Modifications in the Mitochondria of Hypoxia-Adapted Drosophila melanogaster

(2012) Guy Perkins et al.   PLoS One

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of Genes Underlying Hypoxia Tolerance in Drosophila by a P-element Screen

(2012) Priti Azad et al.   G3-Genes Genomes Genetics

An Engineering Approach to Extending Lifespan in C. elegans

(2012) Dror Sagi et al.   PLoS Genetics

EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways

(2012) Lyly G. Luhachack et al.   PLoS Pathogens

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

Hydrogen Sulfide and Cell Signaling

(2011) Ling Li et al.   Annual Review of Pharmacology and Toxicology

Effects of Oxygen on Growth and Size: Synthesis of Molecular, Organismal, and Evolutionary Studies with Drosophila melanogaster

(2011) Jon F. Harrison et al.   Annual Review of Physiology

Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx ofCaenorhabditis elegans

(2011) Mandy Kosel et al.   BIOCHEMICAL JOURNAL

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

The hypoxic response and aging

(2011) Matt Kaeberlein et al.   CELL CYCLE

Eicosanoids in Prevention and Management of Diseases

(2011) J. Szefel et al.   CURRENT MOLECULAR MEDICINE

Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis

(2011) Yukiji Takeda et al.   NATURE

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

TRPA1 underlies a sensing mechanism for O2

(2011) Nobuaki Takahashi et al.   Nature Chemical Biology

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Experimental selection of hypoxia-tolerant Drosophila melanogaster

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary Conserved Regulation of HIF-1β by NF-κB

(2011) Patrick van Uden et al.   PLoS Genetics

Enzymes of cysteine synthesis show extensive and conserved modifications patterns that include Nα-terminal acetylation

(2010) Markus Wirtz et al.   AMINO ACIDS

Hypoxia-Inducible Factor-1α Is Involved in the Pro-angiogenic Effect of Hydrogen Sulfide under Hypoxic Stress

(2010) XinHua Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Structure and assembly of pore-forming proteins

(2010) Ioan Iacovache et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway

(2010) Jian Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production

(2010) Yee Liu Chua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Hydrogen sulfide as a gasotransmitter

(2010) Moataz M. Gadalla et al.   JOURNAL OF NEUROCHEMISTRY

Hypoxia activates a latent circuit for processing gustatory information in C. elegans

(2010) Roger Pocock et al.   NATURE NEUROSCIENCE

Oxygen Sensing in Drosophila: Multiple Isoforms of the Prolyl Hydroxylase Fatiga Have Different Capacity to Regulate HIFα/Sima

(2010) Julieta M. Acevedo et al.   PLoS One

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Plant and Animal Sensors of Conserved Microbial Signatures

(2010) P. C. Ronald et al.   SCIENCE

Hypoxia signaling and resistance in C. elegans

(2010) Jo Anne Powell-Coffman   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF–Dependent Transcription in Hypoxia

(2010) Andrés Dekanty et al.   PLoS Genetics

C. elegans SWAN-1 Binds to EGL-9 and Regulates HIF-1-Mediated Resistance to the Bacterial Pathogen Pseudomonas aeruginosa PAO1

(2010) Zhiyong Shao et al.   PLoS Pathogens

Distinct Pathogenesis and Host Responses during Infection of C. elegans by P. aeruginosa and S. aureus

(2010) Javier E. Irazoqui et al.   PLoS Pathogens

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The mammalian aryl hydrocarbon (Ah) receptor: from mediator of dioxin toxicity toward physiological functions in skin and liver

(2009) Karl Walter Bock et al.   BIOLOGICAL CHEMISTRY

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity

(2009) Jing Xue et al.   GASTROENTEROLOGY

Infections caused by Gram-positive bacteria: a review of the global challenge

(2009) Neil Woodford et al.   JOURNAL OF INFECTION

The von Hippel Lindau Tumor Suppressor Limits Longevity

(2009) R.-U. Muller et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hydrogen Sulfide Increases Hypoxia-inducible Factor-1 Activity Independently of von Hippel–Lindau Tumor Suppressor-1 in C. elegans

(2009) Mark W. Budde et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct Mechanisms Underlying Tolerance to Intermittent and Constant Hypoxia in Drosophila melanogaster

(2009) Priti Azad et al.   PLoS One

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

A Late Archean Sulfidic Sea Stimulated by Early Oxidative Weathering of the Continents

(2009) C. T. Reinhard et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Fat synthesis and adiposity regulation in Caenorhabditis elegans

(2009) Jennifer L. Watts   TRENDS IN ENDOCRINOLOGY AND METABOLISM

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Hypoxia and the Hypoxic Response Pathway Protect against Pore-Forming Toxins in C. elegans

(2009) Audrey Bellier et al.   PLoS Pathogens

Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans

(2008) Jana Kulas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival

(2008) Dumitru A. Iacobas et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

C. elegans dauer formation and the molecular basis of plasticity

(2008) N. Fielenbach et al.   GENES & DEVELOPMENT

Systematic Identification of Gene Activities Promoting Hypoxic Death

(2008) M. E. Mabon et al.   GENETICS

TRPA1 is a major oxidant sensor in murine airway sensory neurons

(2008) Bret F. Bessac et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

(2008) Christina Nassenstein et al.   JOURNAL OF PHYSIOLOGY-LONDON

An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells

(2008) Soo-Jung Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans

(2008) Roger Pocock et al.   NATURE NEUROSCIENCE

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Iron–sulfur cluster biogenesis and human disease

(2008) Tracey A. Rouault et al.   TRENDS IN GENETICS

Mechanisms Underlying Hypoxia Tolerance in Drosophila melanogaster: hairy as a Metabolic Switch

(2008) Dan Zhou et al.   PLoS Genetics

Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death

(2007) Dan Zhou et al.   PHYSIOLOGICAL GENOMICS