DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies

(2013) Drew Stenesen et al.   Cell Metabolism

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

(2013) A. Eijkelenboom et al.   Molecular Systems Biology

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

EvolView, an online tool for visualizing, annotating and managing phylogenetic trees

(2012) Huangkai Zhang et al.   NUCLEIC ACIDS RESEARCH

Gene Expression of the Tumour Suppressor LKB1 Is Mediated by Sp1, NF-Y and FOXO Transcription Factors

(2012) Nicolas Lützner et al.   PLoS One

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila

(2011) Masabumi Funakoshi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

(2011) N. Alic et al.   Molecular Systems Biology

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

Reorganizing the protein space at the Universal Protein Resource (UniProt)

(2011)   NUCLEIC ACIDS RESEARCH

AMP-activated protein kinase: also regulated by ADP?

(2011) D. Grahame Hardie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO

(2010) Eugene Schuster et al.   Molecular Systems Biology

A new DAF-16 isoform regulates longevity

(2010) Eun-Soo Kwon et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

PhyloExplorer: a web server to validate, explore and query phylogenetic trees

(2009) Vincent Ranwez et al.   BMC EVOLUTIONARY BIOLOGY

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans

(2008) David Hoogewijs et al.   BMC MOLECULAR BIOLOGY

An elt-3/elt-5/elt-6 GATA Transcription Circuit Guides Aging in C. elegans

(2008) Yelena V. Budovskaya et al.   CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor

(2008) D. S. Patel et al.   GENETICS

TheCaenorhabditis elegansAMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior

(2008) Hyojin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

(2008) Patrick Narbonne et al.   NATURE

Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans

(2008) Arnab Mukhopadhyay et al.   Nature Protocols

Vector-free DNA constructs improve transgene expression in C. elegans

(2007) John F Etchberger et al.   NATURE METHODS