Review
Ophthalmology
Dongwei Lai, Yang Wu, Chuhan Shao, Qinghua Qiu
Summary: Diabetic macular edema (DME) is a common complication of diabetic retinopathy and results in vision loss for diabetic patients. The precise mechanism of DME is still unclear, although factors such as metabolic disorders and inflammation caused by hyperglycemia are implicated. Muller cells, unique macroglial cells in the retina, play a crucial role in retinal homeostasis. This article reviews the involvement of Muller cells in the pathological process of DME and the advancements in DME treatment through gene therapy targeting Muller cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yun-Zheng Le, Bei Xu, Ana J. Chucair-Elliott, Huiru Zhang, Meili Zhu
Summary: The study demonstrated that VEGF plays a positive regulatory role in promoting BDNF production in diabetes, while BDNF can support MC survival under diabetic conditions. Targeting the BDNF receptor TRK-B can affect the activity of survival and proliferation mediators such as AKT and ERK, and rescuing MC viability loss under diabetic conditions was achieved through rBDNF.
Review
Cell Biology
Shuo Yang, Shounan Qi, Chenguang Wang
Summary: Diabetic retinopathy is a significant complication of diabetes, and the activation and changes in retinal Muller cells play a crucial role in its pathogenesis. Understanding the involvement of Muller cells can provide new targets for the treatment of diabetic retinopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Yang Li, Qinrui Hu, Bin Wang
Summary: This study identified the role of Apelin in promoting fibrogenic activity of Muller cells through activating the JAK2/STAT3 signaling pathway, leading to retinal fibrosis in diabetes retinopathy.
Review
Integrative & Complementary Medicine
Fatemeh Sanie-Jahromi, Zahra Zia, Mehrdad Afarid
Summary: This study reviews the effects of garlic on diabetes, VEGF, and BDNF, as well as its impact on diabetic retinopathy. The findings indicate that garlic has beneficial effects in treating diabetes, inhibiting angiogenesis, and protecting against neurodegeneration. Garlic can be considered as a complementary treatment option for diabetic retinopathy, supported by available clinical evidence.
Article
Ophthalmology
Tianqin Wang, Chaoyang Zhang, Hai Xie, Mengmeng Jiang, Haibin Tian, Lixia Lu, Guo-Tong Xu, Lin Liu, Jingfa Zhang
Summary: VEGF-A plays a key role in diabetic retinal edema, but the mechanisms are not fully understood. Ranibizumab was shown to protect Muller cells from diabetic intracellular edema by up-regulating Kir4.1 and AQP4, as well as reducing intracellular osmotic pressure. The study provides insights into the pathogenesis of diabetic retinal edema and potential therapeutic targets.
Article
Medicine, General & Internal
Chunmiao Wang, Ruijin Ran, Xin Jin, Xiaohong Zhu
Summary: This study found that elevated concentrations of selenium in plasma and vitreous may be an important risk factor for diabetic retinopathy in patients with type 2 diabetes. Additionally, increased VEGF levels in the eyes may be closely related to intraocular selenium concentrations in patients with proliferative diabetic retinopathy.
Article
Biochemistry & Molecular Biology
Sara Rezzola, Jessica Guerra, Adwaid Manu Krishna Chandran, Alessandra Loda, Anna Cancarini, Piergiuseppe Sacristani, Francesco Semeraro, Marco Presta
Summary: Proliferative diabetic retinopathy (PDR) is a major complication of diabetes mellitus, resulting from inflammation among endothelial cells, neurons, and glia. While anti-vascular endothelial growth factor (VEGF) interventions are the current therapeutic option for PDR, their impact on Muller cell activation remains unclear. Additional modulators besides VEGF have been found to play a role in Muller cell activation, suggesting potential for novel therapeutic strategies in PDR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jing Feng, Weiqiang Yang, Fuxiao Luan, Fang Ma, Yingjie Wang, Yiquan Zhang, Xuhui Liu, Li Chen, Xiaofeng Hu, Yong Tao
Summary: Diabetic retinopathy is a common and serious complication of diabetes, and there is currently no effective treatment for early stage. However, apelin has been found to potentially reduce vascular leakage by protecting pericytes, which suggests a promising new direction for early treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Aude Couturier, Guillaume Blot, Lucile Vignaud, Celine Nanteau, Amelie Slembrouck-Brec, Valerie Fradot, Niyazi Acar, Jose-Alain Sahel, Ramin Tadayoni, Gilles Thuret, Florian Sennlaub, Jerome E. Roger, Olivier Goureau, Xavier Guillonneau, Sacha Reichman
Summary: Muller glial cells play a crucial role in maintaining retinal homeostasis and metabolism, but reliable human cell sources for modeling MGC-associated diseases are limited. The newly developed hiMGCs exhibit phenotypic and transcriptomic similarities to pMGCs, making them valuable tools for disease modeling, such as diabetic retinopathy.
Article
Cell Biology
Xiaofeng Ye, Hui Ren, Tingting Jiang, Ting Zhang, Gang Li
Summary: This study aimed to investigate the relationship between diabetic blood-stasis syndrome and ERK1/2-VEGF signaling pathway in rat retina Muller cells, and the efficacy of Traditional Chinese Drugs designed for promoting blood circulation to remove blood stasis in treating diabetic retinopathy (DR). The results showed that stimulation of Muller cells by blood serum from diabetic rats with blood stasis increased VEGF secretion, activated ERK1/2 and AP-1 DNA-binding activity. Treatment with Xuefu Zhuyu decoction and the ERK1/2 signaling pathway inhibitor U0126 weakened these effects. These findings suggest that Traditional Chinese drugs for promoting blood circulation to remove blood stasis could be an effective therapy for DR.
HISTOLOGY AND HISTOPATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Yanqiu Liu, Zifan Xu, Haohan Zheng, Jiahui Yang, Meili Wu, Qian Yang, Yan Wang, Tianyi Zong, Xusheng Yang, Tianhua Xie, Jiping Cai, Yong Yao, Xiaolu Wang
Summary: Diabetic retinopathy (DR) is a common complication of diabetes mellitus and a major cause of visual impairment and blindness in industrialized countries. The miRNA miR-423-5p has been identified as a critical factor in promoting microvascular dysfunction in DR.
Article
Cell Biology
Elena Fico, Pamela Rosso, Viviana Triaca, Marco Segatto, Alessandro Lambiase, Paola Tirassa
Summary: This study found that administration of eye drops containing NGF can prevent histological and vascular alterations caused by diabetic retinopathy. It also regulates the expression of VEGFR2 and/or VEGFA isoforms to counteract vascular impairment. NGF can also reduce inflammatory and pro-apoptotic signals. These findings suggest the importance of NGF in neuroretinal protection.
Article
Neurosciences
Tong Zhu, Yingao Li, Lilin Zhu, Jinyuan Xu, Zijun Feng, Hao Chen, Si Shi, Caiying Liu, Qingjian Ou, Furong Gao, Jieping Zhang, Caixia Jin, Jingying Xu, Jiao Li, Jingfa Zhang, Yanlong Bi, Guo-tong Xu, Juan Wang, Haibin Tian, Lixia Lu
Summary: This study identified GMFB as a sensitive and functional gliosis marker for diabetic retinal degeneration. Knockout of Gmfb improved visual function, attenuated gliosis, and reduced apoptosis in diabetic retinas. RNA sequencing analysis revealed the involvement of TGF-beta 3 in the protective effect of Gmfb knockout. The study provides a novel therapeutic strategy for treating retinal degeneration in patients with diabetic retinopathy.
Article
Endocrinology & Metabolism
Jose-Andres C. Portillo, Jin-Sang Yu, Sarah Vos, Reena Bapputty, Yalitza Lopez Corcino, Alyssa Hubal, Jad Daw, Sahil Arora, Wenyu Sun, Zheng-Rong Lu, Carlos S. Subauste
Summary: CD40 expressed in Muller cells is a central driver of diabetic retinopathy, activating the PLCγ1-ATP-P2X(7)-proinflammatory cytokine pathway and promoting the development of the disease.
Article
Ophthalmology
Zhuyun Qian, Hua Fan, Yong Tao, Wensheng Li, Wei Gu
OCULAR IMMUNOLOGY AND INFLAMMATION
(2020)
Article
Ophthalmology
Zhuyun Qian, Xu Chen, Yong Tao, Wensheng Li, Wei Gu
Summary: In HIV-negative patients receiving multiple intravitreal injections of ganciclovir for CMV retinitis, there is a positive correlation between initial and final visual acuity.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Ophthalmology
Hui Wang, Yong Tao
Summary: The study compared the levels of intraocular cytokines between Fuchs uveitis syndrome (FUS) eyes and senile cataract eyes, finding higher inflammatory cytokine levels in FUS eyes and a significant positive correlation between severity of posterior subcapsular cataract and levels of IL-6 and IL-8 in the aqueous humor.
Article
Ophthalmology
Hao Kang, Yunbo Wei, Ming Liu, Di Yu, Yong Tao
Summary: The study found that patients with ARN caused by VZV had different intraocular T lymphocyte subsets and cytokines profiles compared to non-infectious patients. High percentages of CD8+ T lymphocytes and low CD4/CD8 T cell ratios may be a potential biomarker for the diagnosis of viral-infectious uveitis. Examination of T lymphocytes at inflammatory sites has the potential to become a useful research tool for differentiating viral and non-viral uveitis.
Article
Engineering, Biomedical
Ying Tian, Fan Zhang, Yefeng Qiu, Shuang Wang, Feng Li, Jiawei Zhao, Chao Pan, Yong Tao, Di Yu, Wei Wei
Summary: Injecting exosomes derived from regulatory T cells and conjugated with an anti-VEGF antibody into the eye significantly suppressed ocular neovascularization in mouse and non-human primate models, showing potential for use in other combination therapies.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Tianwei Liang, Zhuyun Qian, Yong Tao, Yaguang Peng, Yanhui Cui, Chengyue Zhang, Chunxia Peng, Lili Liu, Man Hu, Li Li, Ningdong Li
Summary: This study analyzed the relationship between the severity of type 1 retinopathy of prematurity (ROP) and the level of vascular endothelial growth factor (VEGF) in aqueous fluid. The results showed that the aqueous VEGF level was highest in patients with severe ROP and was correlated with the location and venous tortuosity of ROP lesions, indicating the severity of ROP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jing Feng, Weiqiang Yang, Fuxiao Luan, Fang Ma, Yingjie Wang, Yiquan Zhang, Xuhui Liu, Li Chen, Xiaofeng Hu, Yong Tao
Summary: Diabetic retinopathy is a common and serious complication of diabetes, and there is currently no effective treatment for early stage. However, apelin has been found to potentially reduce vascular leakage by protecting pericytes, which suggests a promising new direction for early treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Jian Ji, Yong Tao, Yan Pang
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Xiaojun Wang, Fuxiao Luan, Hua Yue, Cui Song, Shuang Wang, Jing Feng, Xiao Zhang, Wei Yang, Yuxin Li, Wei Wei, Yong Tao
Summary: Due to the complexity of ocular diseases and the natural ocular barriers, drug therapy for these diseases has limitations. With the development of biotechnology, smart materials have been widely tested to treat ocular diseases. This review analyzes recent developments in smart materials and discusses future directions for clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Ying Tian, Yiquan Zhang, Jiawei Zhao, Fuxiao Luan, Yingjie Wang, Fan Lai, Defang Ouyang, Yong Tao
Summary: Dry eye syndrome (DES) is a common ocular disorder characterized by inflammation and increased reactive oxygen species (ROS). Researchers have developed a novel treatment approach by growing cerium oxide nanocrystals on mesenchymal stem cell-derived exosomes (MSCExos). This approach promotes corneal cell growth, scavenges ROS, and effectively suppresses inflammation. The findings highlight the potential of MSCExo-Ce as a promising therapeutic candidate for DES.
Article
Biochemistry & Molecular Biology
Fuxiao Luan, Rui Liu, Jing Li, Xin Ge, Nan Wang, Qihan Guo, Yong Tao, Jianmin Ma
Summary: This study retrospectively analyzed the immune and inflammatory indices of patients with lacrimal-gland benign lymphoepithelial lesion (LGBLEL) and identified independent risk factors, including IgG4, IgG, and C3, for predicting LGBLEL occurrence. The combined diagnostic efficacy of IgG4+IgG+C3 was higher than any single factor. These findings provide valuable reference indices for the diagnosis of LGBLEL.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Immunology
Hao Kang, Hongjian Sun, Yang Yang, Zewen K. Tuong, Minglei Shu, Yunbo Wei, Yu Zhang, Di Yu, Yong Tao
Summary: Single-cell analysis reveals differences in immune cell infiltration and T-cell clonal expansions between Behcet's disease and Vogt-Koyanagi-Harada disease uveitis, providing guidance for precision disease management.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Ophthalmology
Hui Wang, Yong Tao
Summary: The initial best-corrected visual acuity and anterior inflammation grade were related. Treatment significantly improved visual acuity and anterior inflammation. Ocular toxocariasis eyes had higher aqueous humor cytokine levels.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Article
Medicine, General & Internal
Li Chen, Yong Tao, Xiaofeng Hu
AMERICAN JOURNAL OF CASE REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Jing Shang Zhang, Jin Wang, Gu Yu Zhu, Jing Li, Ying Xiong, Mayinuer Yusufu, Hai Long He, Xiu Li Sun, Tian Ju, Yong Tao, Shou Zhi He, Xiu Hua Wan