Article
Cell Biology
Thien T. Phan, Adri Chakraborty, Madison A. Tatum, Ana Lima-Orellana, Andrea J. Reyna, Joseph M. Rutkowski
Summary: During cold exposure, white adipose tissue can remodel itself to release heat, similar to brown adipose tissue. The regulation of body temperature in response to cold is controlled by neural and hormonal signaling. It has been discovered that neurotensin, a small neuropeptide, not only inhibits thermogenesis but is also produced by lymphatic vessels. This study found that inducing lymphangiogenesis in adipose tissue increased the levels of neurotensin and impaired thermogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jorge A. Castorena-Gonzalez
Summary: Research has established a two-way connection between obesity and lymphatic dysfunction, indicating that obesity may lead to lymphedema, with lymphatic valve dysfunction potentially being a critical component of obesity-induced lymphedema.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Zhaoxia Wu, Pengjiao Xi, Yan Zhang, Haomin Wang, Jie Xue, Xuguo Sun, Derun Tian
Summary: Diet-induced obesity is associated with chronic inflammation in the hypothalamus. Overexpression of LKB1 in hypothalamus can attenuate inflammation, reduce food intake and weight gain, improve lipid metabolism, and decrease hepatic fat accumulation. This suggests LKB1 as a potential target for treating obesity and other inflammatory diseases.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Dahee Yeo, Su-Jung Hwang, Ye-Seul Song, Hyo-Jong Lee
Summary: Alpha-humulene has been found to have a protective role against gastric injury in vivo and in vitro by inhibiting histamine release, reducing oxidative stress, increasing antioxidant levels, and stimulating mucosal protective factors. This compound shows potential as a drug candidate for the treatment of stress-induced or alcoholic gastritis.
Article
Cardiac & Cardiovascular Systems
Yifei Zhu, Lei Wen, Sheng Wang, Ka Zhang, Yue Cui, Chi Zhang, Lei Feng, Fan Yu, Yongquan Chen, Ruxing Wang, Xin Ma
Summary: Omega-3 can improve vascular function in obese mice induced by a high-fat diet by enhancing TRPV4 activity, which leads to improved flow-induced vasodilation.
CARDIOVASCULAR RESEARCH
(2021)
Review
Physiology
Faisal Masood, Rohan Bhattaram, Mark Rosenblatt, Andrius Kazlauskas, Jin-Hong Chang, Dimitri T. Azar
Summary: Aberrant lymphatic system function is linked to various pathologies, and while lymphatic vessel regression and dysfunction can worsen some conditions, induced regression may be beneficial in certain cases. However, our understanding of lymphatic vessel regression lags behind that of blood vessel regression. By studying blood vessel regression, we can uncover hallmarks of this phenomenon that could help us better understand lymphatic vessel regression. Current research tools and models can be utilized to advance this field and gain therapeutic insights into select pathologies.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chika Kuroda, Kumiko Ajima, Katsuya Ueda, Atsushi Sobajima, Kazushige Yoshida, Takayuki Kamanaka, Jun Sasaki, Haruka Ishida, Hisao Haniu, Masanori Okamoto, Kaoru Aoki, Hiroyuki Kato, Naoto Saito
Summary: Nanomaterials have great potential for biological applications, but their clinical use is limited by the lack of established safety assessment methods, especially regarding their interactions with lymphatic vessels. Development of new systems to study nanomaterial biokinetics in lymphatic vessels is crucial for advancing the biological applications of nanomaterials.
Article
Food Science & Technology
Yangmian Yuan, Chengyu Liu, Xingrui Chen, Yuyan Sun, Mingrui Xiong, Yu Fan, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng
Summary: The study suggests that Tet1 plays a crucial role in obesity by promoting lipolysis and reducing obesity. Vitamin C can treat obesity by enhancing Tet1 activity, thus decreasing hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Developmental Biology
Sandy Hanssens, Lucie Marousez, Oceane Pecheux, Capucine Besengez, Laurent Storme, Philippe Deruelle, Delphine Eberle, Jean Lesage
Summary: This study found that obesity reduces the levels of apelin in cord blood, but has no effect on maternal and cord blood levels of elabela or placental gene expression of this system.
Article
Environmental Sciences
Chao Li, Liang Shi, Yuanbo Wang, Cheng Peng, Lei Wu, Yanshu Zhang, Zhongjun Du
Summary: Environmental exposure to lead can damage the central nervous system in humans, and high-fat diet has been suggested to impair neurocognitive function. This study investigated how high-fat diet exacerbates lead-induced disruption of blood-brain barrier integrity by disrupting tight junctions. The results showed that palmitic acid, a common saturated fatty acid, can increase BBB permeability and decrease the expression of tight junction proteins.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Hee Yang, Gihyun Hur, Tae Kyung Lee, Jong-Eun Kim, Jong Hun Kim, Jong Rhan Kim, Jiyoung Kim, Jung Han Yoon Park, Ki Won Lee
Summary: This study found that sulforaphane (SFN), a natural HDAC inhibitor, can prevent obesity-related metabolic dysregulation by enhancing mitochondrial biogenesis and function via targeting the HDAC8-PGC alpha axis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Panying Xiang, Yushi Du, Guanyu Chen, Yihui Mao, Shuangshuang Li, Qing Li, Yuting Yang, Xueyu Li, Dongliang Wang
Summary: In this study, it is shown that a dietary achievable dose of PCA attenuates high-fat diet-induced adiposity by enhancing fatty acid oxidation without activating adipose thermogenesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dan Liang, Liang Zhang, Hongzhu Chen, Hong Zhang, Honghai Hu, Xiaofeng Dai
Summary: Potato resistant starch type 3 (PRS) can regulate high fat diet-induced metabolic syndrome, promote intestinal cell proliferation, reduce Firmicutes/Bacteroidetes ratio, regulate intestinal microbiota abundance and metabolites, and are associated with anti-obesity potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Yangie Dwi Pinanga, Han Ah Lee, Eun-Ae Shin, Haesong Lee, Kyung-hee Pyo, Ji Eon Kim, Eun Hae Lee, Wonsik Kim, Soyeon Kim, Hwi Young Kim, Jung Weon
Summary: The study found that TM4SF5 in the liver is involved in the development of non-alcoholic steatohepatitis (NASH), although the underlying mechanisms are unclear. Through mouse models and samples from NAFLD patients, it was discovered that TM4SF5 can trigger steatohepatitic features by regulating food intake behaviors and multiple metabolic pathways.
Article
Cardiac & Cardiovascular Systems
Stephanie Robillard, Kien Tran, Marie-Sophie Lachance, Tristan Brazeau, Elizabeth Boisvert, Farah Lizotte, Mannix Auger-Messier, Pierre-Luc Boudreault, Eric Marsault, Pedro Geraldes
Summary: This study investigated the impact of Pyr-apelin-13 in endothelial cell function and a diabetic mouse model of hindlimb ischemia. The results showed that Pyr-apelin-13 improves blood flow reperfusion, functional recovery and vascular density in diabetic mice with hindlimb ischemia. Furthermore, Pyr-apelin-13 exerts its proangiogenic actions through Akt/AMPK/eNOS and RhoA/ROCK signaling pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Dermatology
Yuko Matsumoto-Okazaki, Junko Yamane, Kentaro Kajiya
JOURNAL OF DERMATOLOGICAL SCIENCE
(2015)
Article
Nutrition & Dietetics
Kaedeko Fukada, Mika Kajiya-Sawane, Yuko Matsumoto, Tatsuya Hasegawa, Yukitaka Fukaya, Kentaro Kajiya
NUTRITION RESEARCH
(2016)
Editorial Material
Dermatology
Kentaro Kajiya, Mika Kajiya-Sawane, Takayuki Ono, Katsujiro Sato
JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Yusuke Hara, Toyonobu Yamashita, Kumiko Kikuchi, Yoshihide Kubo, Chika Katagiri, Kentaro Kajiya, Souichi Saeki
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Letter
Dermatology
Yuzo Yoshida, Kentaro Kajiya, Jiro Kishimoto, Michael Detmar
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Article
Dermatology
Kentaro Kajiya, Yuko Matsumoto-Okazaki, Mika Sawane, Kaedeko Fukada, Yuya Takasugi, Tomonori Akai, Naoki Saito, Yuichiro Mori
EXPERIMENTAL DERMATOLOGY
(2014)
Letter
Dermatology
Kentaro Kajiya, Ryoma Bise, Catharina Commerford, Imari Sato, Toyonobu Yamashita, Michael Detmar
JOURNAL OF DERMATOLOGICAL SCIENCE
(2018)
Letter
Oncology
Takako Shibata, Kentaro Kajiya, Kiyoshi Sato, Jisun Yoon, Hee Young Kang
PIGMENT CELL & MELANOMA RESEARCH
(2018)
Letter
Peripheral Vascular Disease
Kaedeko Fukada, Kentaro Kajiya
Article
Multidisciplinary Sciences
Yasuhiro Yoshimatsu, Shiori Kimuro, Joris Pauty, Kazuki Takagaki, Sanae Nomiyama, Akihiko Inagawa, Kentaro Maeda, Katarzyna A. Podyma-Inoue, Kentaro Kajiya, Yukiko T. Matsunaga, Tetsuro Watabe
Article
Peripheral Vascular Disease
Mika Sawane, Yuki Ogura, Ayano Nakamura, Hitomi Otaka, Hiroyasu Kidoya, Katsujiro Sato, Nobuyuki Takakura, Kentaro Kajiya
Summary: The study found that appropriate stiffness induces vascular maturation and upregulated APJ expression, while overexpression of APJ promotes the formation of large vessels, potentially providing a novel mechanism for preventing human skin aging.
Article
Dermatology
Moe Tsutsumi, Saito Sakaguchi, Kazuki Takagaki, Jeremy Cheret, Ralf Paus, Kentaro Kajiya
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Ilaria Piccini, Jeremy Cheret, Moe Tsutsumi, Saito Sakaguchi, Leslie Ponce, Luis Almeida, Wolfgang Funk, Maximilian Kueckelhaus, Kentaro Kajiya, Ralf Paus, Marta Bertolini
Summary: Recent research has found that epidermal Merkel cells (MCs) not only have mechanotransduction function for light-touch sensory stimuli, but also are thermosensitive, suggesting a physiological role beyond mechanosensation. Functional olfactory receptors, specifically OR2AT4, were found to be expressed by epidermal MCs in healthy human skin, similar to neighboring keratinocytes. Stimulation of OR2AT4 by topical application of the synthetic odorant Sandalore significantly increased Piccolo protein expression in MCs, indicating increased vesicle trafficking and recycling, and reduced nerve growth factor (NGF) immunoreactivity within MCs, potentially suggesting increased neurotrophin release upon OR2AT4 activation. Further investigation is needed to explore whether these newly discovered properties of MCs are dysregulated in specific skin disorders and if they can be targeted therapeutically to maintain/promote skin health.
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Kentaro Kajiya
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2016)
Article
Ophthalmology
Yuko Maruyama, Kazuichi Maruyama, Yukinari Kato, Kentaro Kajiya, Satoru Moritoh, Kotaro Yamamoto, Yuko Matsumoto, Mika Sawane, Dontscho Kerjaschki, Toru Nakazawa, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)